M. Sugden

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Aliases
Mary C Sugden, M.c Sugden, Mary Sugden, Mary c. Sugden, M. Sugden, Mary C. Sugden, M Sugden, M C Sugden, M.c. Sugden, M. C. Sugden
Publication record
275 papers · 7,491 citations · H-index 45

PAPERS

Receptors | Peroxisome Proliferator-Activated Receptors
20211 citationsauthor #1
Pathophysiology of diabetic dyslipidemia:implications for atherogenesis and treatment
20178 citationsauthor #1
Time-of-flight secondary ion mass spectrometer: a novel tool for lipid imaging
20171 citationsauthor #1
A Key Role for Interferon Regulatory Factors in Mediating Early-Life Metabolic Defects in Male Offspring of Maternal Protein Restricted Rats
20144 citationsauthor #5
The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions.
201442 citationsauthor #17
Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
2013106 citationsauthor #10
The involvement of PPARs in the causes, consequences and mechanisms for correction of cardiac lipotoxicity and oxidative stress.
20126 citationsauthor #1
Actions and interactions of AMPK with insulin, the peroxisomal-proliferator activated receptors and sirtuins
20125 citationsauthor #4
Damaging Loss of Self-Control by Stressed β-Cells
20124 citationsauthor #2
Metformin, metabolic stress, and mitochondria. Focus on "A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells".
201215 citationsauthor #1
1262 ROLE OF SIRT1 AND AMPK IN THE DEVELOPMENT OF INSULIN RESISTANCE ASSOCIATED TO NON-ALCOHOLIC FATTY LIVER DISEASE
20120 citationsauthor #2
Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity
201214 citationsauthor #4
Magnetic resonance techniques for mapping fat deposits and directing therapy
20110 citationsauthor #1
PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
201141 citationsauthor #4
Chapter 2:Autocrine Effects in White Adipose Tissue and Pancreatic Islets: Emergent Roles in the Regulation of Adipocyte and Pancreatic β-cell Function
20110 citationsauthor #1
Pathophysiology of diabetic dyslipidemia:implications for atherogenesis and treatment
201148 citationsauthor #1
Recent advances in biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis: the role of lipid analysis/ profiling
20110 citationsauthor #1
Lysophosphatidic acid effects on atherosclerosis and thrombosis
201117 citationsauthor #1
The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?
201156 citationsauthor #1
Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
2011128 citationsauthor #5
Management of dyslipidemia in HIV-infected patients
20112 citationsauthor #1
Time-of-flight secondary ion mass spectrometer: a novel tool for lipid imaging
20119 citationsauthor #1
Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db mice
2011101 citationsauthor #5
Signalling satiety and starvation to β-Cell insulin secretion.
20116 citationsauthor #3
Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity
201186 citationsauthor #3
PPAR control: it's SIRTainly as easy as PGC.
2010206 citationsauthor #1
Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function.
201039 citationsauthor #3
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.
201026 citationsauthor #8
The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo
200968 citationsauthor #2
PPARs and the orchestration of metabolic fuel selection.
200958 citationsauthor #1
The role of PPARs in modulating cardiac metabolism in diabetes.
200911 citationsauthor #3
PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.
200825 citationsauthor #4
PDC deletion: the way to a man's heart disease.
20089 citationsauthor #1
Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance.
200848 citationsauthor #1
PPAR (cid:1) activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic (cid:2) -cell function in late pregnancy
20070 citationsauthor #4
PPARα activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic β-cell function in late pregnancy
200715 citationsauthor #4
In appreciation of Sir Philip Randle: the glucose-fatty acid cycle.
200725 citationsauthor #1
PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy.
20079 citationsauthor #4
Diet, obesity and diabetes: a current update.
200763 citationsauthor #4
Prolactin in culture leads to a shift in stimulatory threshold but does not augment the K-ATP channel independent pathway for glucose-stimulated insulin secretion
20070 citationsauthor #4
Regulation of Mitochondrial Fuel Handling by the Peroxisome Proliferator-Activated Receptors
20070 citationsauthor #1
Modifications of pyruvate handling in health and disease
20070 citationsauthor #1
Skeletal muscle lipid metabolism and the adipomuscular axis
20067 citationsauthor #1
Peroxisome Proliferator–Activated Receptor-α and Glucocorticoids Interactively Regulate Insulin Secretion During Pregnancy
200615 citationsauthor #4
Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases
2006276 citationsauthor #1
Epigenetic regulation of metabolism in children born small for gestational age
200659 citationsauthor #2
Early protein restriction attenuates effects of increased age to suppress the response of adipose-tissue LPL activity to feeding
20060 citationsauthor #3
Interactive influences of peroxisome proliferator-activated receptor α activation and glucocorticoids on pancreatic beta cell compensation in insulin resistance induced by dietary saturated fat in the rat
200529 citationsauthor #4
HEPATIC LIPOGENESIS AND THYROID HORMONE
20050 citationsauthor #1
LIPOGENESIS INHIBITION IN HEPATOCYTES
20050 citationsauthor #4
Hyperthyroidism impairs pancreatic beta cell adaptations to late pregnancy and maternal liporegulation in the rat
20057 citationsauthor #4
Stimulation of [ 1-14 C ] oleate oxidation to 14 CO 2 in isolated rat hepatocytes by the catecholamines , vasopressin and angiotensin A possible mechanism of action
20050 citationsauthor #1
Acute omega-3 fatty acid enrichment selectively reverses high-saturated fat feeding-induced insulin hypersecretion but does not improve peripheral insulin resistance.
200453 citationsauthor #4
Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion.
200454 citationsauthor #1
Peroxisome Proliferator-Activated Receptors
20040 citationsauthor #1
Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.
200336 citationsauthor #4
Diabetogenic impact of long-chain omega-3 fatty acids on pancreatic beta-cell function and the regulation of endogenous glucose production.
200336 citationsauthor #4
Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness.
200322 citationsauthor #1
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.
2003507 citationsauthor #1
Diabetogenic Impact of Long-Chain ω-3 Fatty Acids on Pancreatic β-Cell Function and the Regulation of Endogenous Glucose Production
200356 citationsauthor #4
Trials, tribulations and finally, a transporter: the identification of the mitochondrial pyruvate transporter.
200314 citationsauthor #1
Effects of prenatal glucocorticoid exposure on cardiac calreticulin and calsequestrin protein expression during early development and in adulthood.
200335 citationsauthor #3
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation.
2003465 citationsauthor #2
Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.
200384 citationsauthor #4
PDK4: A factor in fatness?
200336 citationsauthor #1
Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
200343 citationsauthor #2
Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).
200267 citationsauthor #4
PPARalpha activation during late pregnancy improves insulin action and attenuates glucose-stimulated insulin hypersecretion
20020 citationsauthor #3
Peroxisome-proliferator-activated receptor-α (PPARα) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin
2002134 citationsauthor #1
Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism.
200269 citationsauthor #6
Gender-specific programming of insulin secretion and action.
2002148 citationsauthor #1
Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.
200245 citationsauthor #1
Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin.
200267 citationsauthor #1
Activation of peroxisome-proliferator-activated receptor (PPAR) alpha reverses high-fat induced insulin hypersecretion in perifused pancreatic islets
20020 citationsauthor #4
Fuel-sensing mechanisms integrating lipid and carbohydrate utilization.
2001107 citationsauthor #1
Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.
200160 citationsauthor #1
Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring.
2001142 citationsauthor #1
Excessive glucocorticoid exposure during late intrauterine development modulates the expression of cardiac uncoupling proteins in adult hypertensive male offspring
200140 citationsauthor #3
Regulation and impact of changes in PPARalpha expression on glucose-stimulated insulin secretion by pancreatic islets
20010 citationsauthor #1
Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation.
200196 citationsauthor #2
Glucocorticoid excess leads to redistribution of available pyruvate from oxidation to maintain a normal rate of lactate formation via up-regulation of skeletal-muscle pyruvate dehydrogenase kinase 4 expression
20010 citationsauthor #4
Antecedent protein restriction and high-fat feeding interactively sensitise the leptin response to elevated insulin.
20015 citationsauthor #2
Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation.
200118 citationsauthor #1
Early growth retardation induced by excessive exposure to glucocorticoids in utero selectively increases cardiac GLUT1 protein expression and Akt/protein kinase B activity in adulthood.
200155 citationsauthor #3
Dexamethasone during Late Gestation Exacerbates Peripheral Insulin Resistance and Selectively Targets Glucose-Sensitive Functions in β Cell and Liver.
200139 citationsauthor #2
Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding.
200169 citationsauthor #1
Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver.
200122 citationsauthor #2
Selective modification of the pyruvate dehydrogenase kinase isoform profile in skeletal muscle in hyperthyroidism: implications for the regulatory impact of glucose on fatty acid oxidation.
200023 citationsauthor #1
Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression.
2000106 citationsauthor #1
Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.
2000174 citationsauthor #4
Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.
200082 citationsauthor #1
Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus.
2000140 citationsauthor #3
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.
199912 citationsauthor #2834
Substrate interactions in the short- and long-term regulation of renal glucose oxidation.
199918 citationsauthor #1
Protein restriction during early development enhances insulin responsiveness but selectively impairs sensitivity to insulin at low concentrations in white adipose tissue during a later pregnancy
199919 citationsauthor #3
Current concepts concerning the role of leptin in reproductive function.
199995 citationsauthor #3
In late pregnancy insulin-dependent glucose transport/phosphorylation is selectively impaired and activation of glycogen synthase by insulin facilitated in skeletal muscles of 24-h starved rats
19998 citationsauthor #2
DEXAMETHASONE ADMINISTRATION IN ADULTHOOD LEADS TO CARDIAC PROTEIN KINASE C EXPRESSION REMINISCENT OF EARLY DEVELOPMENT
19990 citationsauthor #3
Hyperthyroidism Facilitates Cardiac Fatty Acid Oxidation Through Altered Regulation of Cardiac Carnitine Palmitoyltransferase: Studies in Vivo and with Cardiac Myocytes
199916 citationsauthor #1
Caloric restriction leads to regional specialisation of adipocyte function in the rat.
199911 citationsauthor #1

TIMELINE

1976 135 citations

1977 14 citations

1978 12 citations

1979 164 citations

1980 79 citations

1981 19 citations

1982 41 citations

1983 102 citations

1984 41 citations

1985 81 citations

1986 57 citations

1987 145 citations

1988 245 citations

1989 217 citations

1990 141 citations

1991 53 citations

1992 101 citations

1993 232 citations

1994 152 citations

1995 116 citations

1996 73 citations

1997 103 citations

1998 99 citations

1999 228 citations

2000 525 citations

2001 653 citations

2002 530 citations

2003 1,334 citations

2004 107 citations

2005 36 citations

2006 357 citations

2007 112 citations

2008 82 citations

2009 137 citations

2010 271 citations

2011 494 citations

2012 44 citations

2013 106 citations

2014 46 citations

2017 9 citations

2021 1 citations

M. Sugden

PROFILE

PAPERS

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