W. Tolbert

PROFILE

Homepage
No homepage is listed.
ORCID
No ORCID is listed.
Affiliations
No affiliations are listed.
Aliases
W. David Tolbert, W. D. Tolbert, W.david Tolbert, William D. Tolbert, W D Tolbert, W. Tolbert, William D Tolbert, W.d. Tolbert, William David Tolbert, William Tolbert
Publication record
171 papers · 2,131 citations · H-index 27

PAPERS

CD4-mimetics sensitize HIV-infected cells to ADCC mediated by plasma from persons with early-stage HIV-1 infection
20253 citationsauthor #6
CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWH
20255 citationsauthor #5
Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in human and macaque
20250 citationsauthor #1
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
20252 citationsauthor #6
CD4 T cell counts are inversely correlated with anti-cluster A antibodies in antiretroviral therapy-treated PLWH.
20250 citationsauthor #5
Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants
20250 citationsauthor #11
The impact of N-glycan conformational entropy on the binding affinity of Fc γ receptor IIIa/CD16a.
20250 citationsauthor #2
A Dual-Specificity d-Peptide Antagonist of MDM2 and MDMX for Antitumor Immunotherapy.
20251 citationsauthor #3
A gp41 HR2 residue modulates the susceptibility of HIV-1 envelope glycoproteins to small molecule inhibitors targeting gp120
20251 citationsauthor #9
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV.
20250 citationsauthor #5
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
20251 citationsauthor #14
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
20245 citationsauthor #18
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics
20243 citationsauthor #14
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics
20247 citationsauthor #14
Immune response profiles from humans experimentally exposed to Phlebotomus duboscqi bites
20244 citationsauthor #12
Optimization of a Piperidine CD4-Mimetic Scaffold Sensitizing HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
20242 citationsauthor #5
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
20245 citationsauthor #5
Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing
20241 citationsauthor #10
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
20244 citationsauthor #18
Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC
202310 citationsauthor #2
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.
202321 citationsauthor #12
The structural basis for macaque Fc α receptor (CD89) activation by IgA Fc
20230 citationsauthor #1
The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11
20235 citationsauthor #1
Plasmatic HIV-1 soluble gp120 is associated with immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.
20230 citationsauthor #4
Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir
20234 citationsauthor #4
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir
20237 citationsauthor #4
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia
202317 citationsauthor #4
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19
202218 citationsauthor #6
Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s
20221 citationsauthor #1
Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt
20226 citationsauthor #5
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
2022102 citationsauthor #5
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
202224 citationsauthor #7
Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques
202212 citationsauthor #1
Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates
20225 citationsauthor #3
Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain
20220 citationsauthor #6
Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD
20229 citationsauthor #6
Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression
202126 citationsauthor #7
Across functional boundaries: making non-neutralizing antibodies to neutralize HIV-1 and mediate Fc-mediated effector killing of infected cells
20211 citationsauthor #3
Crystal structure of a human afucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
20210 citationsauthor #1
CRYSTAL STRUCTURE OF RHESUS MACAQUE (MACACA MULATTA) IGG1 FC FRAGMENT- FC-GAMMA RECEPTOR III COMPLEX V158 MUTANT
20210 citationsauthor #1
Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells
202112 citationsauthor #3
An anti-SARS-CoV-2 non-neutralizing antibody with Fc-effector function defines a new NTD epitope and delays neuroinvasion and death in K18-hACE2 mice
202114 citationsauthor #5
Crystal structure of a human fucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
20210 citationsauthor #1
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern
202183 citationsauthor #14
Erratum for Tolbert et al., “Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial”
20211 citationsauthor #1
Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
20219 citationsauthor #3
Crystal Structure of SARS-CoV-2 S receptor-binding domain (RBD) in complex CoV11 Fab
20210 citationsauthor #1
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
202126 citationsauthor #7
Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer
20218 citationsauthor #1
Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern
202156 citationsauthor #14
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19
20214 citationsauthor #6
Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions
20217 citationsauthor #2
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-IV-226.
20200 citationsauthor #1
Crystal structure of the broadly neutralizing antibody N49P6 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core.
20200 citationsauthor #1
Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site
20200 citationsauthor #1
Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding.
202036 citationsauthor #5
Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial
20208 citationsauthor #1
Crystal structure of broadly neutralizing antibody N49P9.1 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core
20200 citationsauthor #1
CRYSTAL STRUCTURE OF THE NON-NEUTRALIZING AND ADCC-POTENT ANTIBODY C11 IN COMPLEX WITH HIV-1 CLADE A/E GP120
20200 citationsauthor #1
HIV-1 CD4 binding site antibody N49P6 mimics CD4 in its quaternary interactions with the HIV-1 envelope trimer
20200 citationsauthor #1
The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site
202034 citationsauthor #2
CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 LM/HS CLADE A/E CRF01 GP120 CORE
20200 citationsauthor #1
CRYSTAL STRUCTURE OF HIV-1 LM/HS CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH BNM-III-170
20200 citationsauthor #1
Crystal structure of broadly neutralizing antibody N49P6 Fab in complex with HIV-1 BG505 SOSIP.664 Env trimer ectodomain.
20200 citationsauthor #1
CRYSTAL STRUCTURE OF the RV144 C1-C2 SPECIFIC ANTIBODY CH55 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120
20200 citationsauthor #1
Effects of gp120 Inner Domain (ID2) Immunogen Doses on Elicitation of Anti-HIV-1 Functional Fc-Effector Response to C1/C2 (Cluster A) Epitopes in Mice
20201 citationsauthor #2
CRYSTAL STRUCTURE OF THE RV144 C1-C2 SPECIFIC ANTIBODY CH55 FAB
20200 citationsauthor #3
Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation
20208 citationsauthor #3
CRYSTAL STRUCTURE OF HIV-1 LM/HS CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH (S)-MCG-IV-210
20200 citationsauthor #1
Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site
202024 citationsauthor #1
CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE
20200 citationsauthor #1
CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 3)
20190 citationsauthor #1
CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies
201930 citationsauthor #5
Systematic mutational analysis of human neutrophil α-defensin HNP4.
201915 citationsauthor #3
Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1
20190 citationsauthor #1
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-III-188-A01.
20190 citationsauthor #1
Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency
201921 citationsauthor #4
Crystal structure of the RV144 C1-C2 specific antibody CH54 Fab in complex with HIV-1 CLADE A/E GP120 and M48U1
20190 citationsauthor #2
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-III-027-D05.
20190 citationsauthor #1
Crystal structure of the ADCC potent antibody DH677.3 Fab elicited in the RV305 vaccine trial.
20190 citationsauthor #2
CRYSTAL STRUCTURE OF HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH (S)-MCG-IV-210.
20190 citationsauthor #1
Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region
20199 citationsauthor #8
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.
2019101 citationsauthor #10
Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) IgG1.
20190 citationsauthor #2
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-IV-031-A05.
20190 citationsauthor #1
Crystal structure of a Fc fragment of Human IgG3
20190 citationsauthor #2
Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2)
20190 citationsauthor #2
Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 1)
20190 citationsauthor #2
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-III-188-A02.
20190 citationsauthor #1
CRYSTAL STRUCTURE OF RHESUS MACAQUE (MACACA MULATTA) IGG1 Fc Fragment-Fc-GAMMA RECEPTOR III complex
20190 citationsauthor #2
Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity
201924 citationsauthor #1
CRYSTAL STRUCTURE OF RHESUS MACAQUE (MACACA MULATTA) FC-GAMMA RECEPTOR III
20190 citationsauthor #2
Boosting with ALVAC-HIV and AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity
20192 citationsauthor #4
Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
20197 citationsauthor #5
The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope
201932 citationsauthor #4
A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity
201927 citationsauthor #3
Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) IgG3
20192 citationsauthor #1
From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses
201922 citationsauthor #1
Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env
201935 citationsauthor #3
P-D8 New insights on the human anti-HIV-1 Env antibody-mediated cell cytotoxicity (ADCC) against HIV-1 virus: Allosteric regulation of FcRs binding upon antigen engagement
20180 citationsauthor #5

TIMELINE

1985 0 citations

1996 6 citations

1999 3 citations

2000 33 citations

2001 185 citations

2003 74 citations

2007 162 citations

2010 73 citations

2012 0 citations

2013 27 citations

2014 103 citations

2015 100 citations

2016 182 citations

2017 34 citations

2018 191 citations

2019 327 citations

2020 111 citations

2021 247 citations

2022 177 citations

2023 64 citations

2024 31 citations

2025 13 citations

Unknown 0 citations

W. Tolbert

PROFILE

PAPERS

TIMELINE

COAUTHOR MAP

CONCEPT FOOTPRINT