HERC2 depletion counteracts BARD1 depletion by restoring BRCA1 expression and G2-M checkpoint activity.

From HERC2 is an E3 ligase that targets BRCA1 for degradation. Confidence 0.94

SOURCE RECORD

Source paper
HERC2 is an E3 ligase that targets BRCA1 for degradation.
Confidence
0.94
Contributors
박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review

LINKED CONCEPTS

herc2
protein, enzyme
brca1
protein, tumor suppressor
bard1
protein, binding partner
g2-m checkpoint activity
cell-cycle checkpoint

CLAIM MAP