brca1

A breast cancer suppressor protein that forms a heterodimeric E3 ligase complex with BARD1.

• Types

  protein, tumor suppressor

• Aliases

  No aliases are listed.

• Contributors
  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review

• HERC2 is an E3 ligase that targets BRCA1 for degradation.

  145 citations

• HERC2 functions as an E3 ubiquitin ligase that targets BARD1-uncoupled BRCA1 for degradation through BRCA1 ubiquitination.
• HERC2-BRCA1 interaction is maximal during S phase and rapidly diminishes as cells enter G2-M, inversely tracking BRCA1 abundance.
• HERC2 depletion counteracts BARD1 depletion by restoring BRCA1 expression and G2-M checkpoint activity.
• BARD1 protects BRCA1 from HERC2-mediated ubiquitination.

• No direct concept-to-concept edges are published yet.

• herc2

  protein, enzyme1 shared papers
• bard1

  protein, binding partner1 shared papers
• ubiquitination

  post-translational modification1 shared papers
• herc2-brca1 interaction

  molecular interaction, protein interaction1 shared papers
• s phase

  cell-cycle phase1 shared papers
• g2-m phase

  cell-cycle phase1 shared papers
• g2-m checkpoint activity

  cell-cycle checkpoint1 shared papers