herc2-brca1 interaction

The physical association between HERC2 and BRCA1, mediated here by HERC2's COOH-terminal HECT-containing domain and the BRCA1 NH2-terminal degron domain.

• Types

  molecular interaction, protein interaction

• Aliases

  HERC2-BRCA1 binding

• Contributors
  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review

• HERC2 is an E3 ligase that targets BRCA1 for degradation.

  145 citations

• HERC2-BRCA1 interaction is maximal during S phase and rapidly diminishes as cells enter G2-M, inversely tracking BRCA1 abundance.

• No direct concept-to-concept edges are published yet.

• herc2

  protein, enzyme1 shared papers
• brca1

  protein, tumor suppressor1 shared papers
• bard1

  protein, binding partner1 shared papers
• ubiquitination

  post-translational modification1 shared papers
• s phase

  cell-cycle phase1 shared papers
• g2-m phase

  cell-cycle phase1 shared papers
• g2-m checkpoint activity

  cell-cycle checkpoint1 shared papers