Antagonism of rutin to capillary effects of sodium bisulfite and procaine.

1. Reference is made to earlier work demonstrating the ability of sodium bisulfite to augment the toxicity of certain drugs by hastening their absorption from intramuscular and subcutaneous sites. 2. The increase of epinephrine toxicity in rats caused by sodium bisulfite was abolished by previous administration of rutin, whereas the toxicity of epinephrine HCl solution alone was not affected by rutin. 3. Rutin pretreatment decreased the toxicity of procaine HCl solutions with and without sodium bisulfite; in contrast, metrazol toxicity was not affected. 4. The conditions which enable sodium bisulfite to increase the toxicity of certain drugs are considered and the name "bisulfite phenomenon" is suggested for this action. 5. The effect of rutin upon certain functions of the capillaries is discussed with particular reference to the "bisulfite phenomenon". 6. The antagonism between the bisulfite phenomenon and rutin as described in this work makes feasible quantitative studies of certain actions of this flavone.

• Publication year

  1948

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1948-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)03621-3PMID 18105655
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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