Effect of rutin on permeability of cutaneous capillaries.

Investigations have been made on the use of trypan blue for the testing of cutaneous capillary permeability in rabbits after applying chloroform to the skin; after intracutaneous injection of histamine, and after applying 30 mm. of mercury negative pressure to the skin. The intravenous administration to rabbits of rutin in doses of 100 or 200 mgm. per kilo of body weight definitely decreased cutaneous capillary permeability as determined by the methods employed.

• Publication year

  1947

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1947-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)05794-5PMID 20265813
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rutin; a new drug for the treatment of increased capillary fragility.

  1946cited by this paper
• Observations on the nature of vitamin P and the vitamin P potency of certain foodstuffs.

  1945cited by this paper
• A biological test for vitamin P activity.

  1942cited by this paper

• Lymphatic metabolites of quercetin after intestinal administration of quercetin-3-glucoside and its aglycone in rats.

  2018cites this paper
• The present study was designed for isolation of bioactive polyphenolic compounds from methanol extract of Azolla microphylla and their subsequent characterization. The flavonoid compounds were isolated and characterized by using thin layer chromatography (TLC), purified by preparative thin layer chr

  2017cites this paper
• HPLC FINGER PRINTS OF PHENOLIC COMPOUNDS PRESENT IN ACTINIOPTERIS RADIATA (SWARTZ) LINK

  2016cites this paper
• ISOLATION AND STRUCTURAL ELUCIDATION OF FLAVONOIDS FROM AQUATIC FERN AZOLLA MICROPHYLLA AND EVALUATION OF FREE RADICAL SCAVENGING ACTIVITY

  2013cites this paper
• Pharmacodynamics and pharmacokinetics of Veliten (rutine, alpha-tocopherol and ascorbic acid) in patients with chronic venous insufficiency.

  1994cites this paper
• Veinotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract.

  1994cites this paper
• Therapeutic value of hidrosmin in the treatment of venous disorders of the lower limbs

  1992cites this paper
• Pharmacodynamics of troxerutine in patients with chronic venous insufficiency: correlations with plasma drug levels.

  1990cites this paper
• Effects of beta-hydroxyethyl rutosides (H-R) administered post burn after thermal-injury-induced plasma volume loss in the nonresuscitated dog.

  1982cites this paper
• Effects of H-R upon post-burn plasma volume loss in the nonresuscitated dog

  1981cites this paper
• 6 Flavonoids: Some Physiological and Nutritional Considerations

  1977cites this paper
• Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity.

  1976cites this paper
• (+)-Catechin effects on X-rays irradiated skin of rats

  1975cites this paper
• Formaldehyde-induced ocular hypertension: the effects of polyphloretin phosphate and (plus)-catechin.

  1974cites this paper
• [Synthesis and study of pharmacodynamic properties of several benzo-gamma-pyronic amides halogenated in the nucleus].

  1973cites this paper
• [Pharmacodynamic study of 6-chloro-chromone-2-carboxylic acid and 2,3-chromone butanolide].

  1972cites this paper
• Pharmacologic effects of flavonoids on blood vessels.

  1972cites this paper
• The pharmacology S 1702, a new highly effective oral antidiabetic drug with unusual properties. 3. Antistickiness activity, fibrinolytic properties and haemostatic parameters study.

  1972cites this paper
• [Effects of certain hydroxybenzoic acids on capillary permeability: relation to the chemical displacement of the phenol proton].

  1970cites this paper
• [Angioprotective power of several chromone-carboxylic-2 acid salts: relation to amino pKa].

  1970cites this paper
• [Study of the effects of diethylamine carboxylate-2 chromone on capillary permeability. Tests based on dye diffusion].

  1970cites this paper
• A simple procedure for the quantitative extraction of extravasated dye in skin tissue.

  1969cites this paper
• [Vitamin P (vegetable polyphenol), its chemical nature and its mechanism of physiological action].

  1969cites this paper
• [Fluorimetric determination of vitamin K and P in drug associations].

  1968cites this paper
• [Studies to the effect of drugs on the plasmalymph-barrier of rats after the estabolshment of a condition of increased capillary permeability].

  1967cites this paper
• [Dihydroergocristine: different effects on venous and arterial tissue].

  1967cites this paper
• [The effect of drugs--especially flavonoids and aescin--on the lymph flow and the permeability of the intact plasma-lymph barrier of rats for fluid and defined macromolecules].

  1966cites this paper
• Effect of Isoramnetol on Capillary Permeability

  1966cites this paper
• [RESEARCH IN THE BENZOFURAN SERIES. X. PHARMACOLOGIC AND TOXICOLOGIC STUDY OF 2-ETHYL-3-(4-HYDROXYBENZOYL)-BENZOFURAN].

  1965cites this paper
• [EFFECT OF HORSE-CHESTNUT ON THE CAPILLARY PERMEABILITY OF THE LONG-TERM ALCOHOLIC RABBIT. INFLUENCE OF THIAMINE].

  1964cites this paper
• [ACTION ON CAPILLARY PERMEABILITY OF VARIOUS TYPES OF FLAVONOIDS].

  1964cites this paper
• Mesure De La Perméabilité Capillaire Chez Le Rat Technique Et Applications Pharmacologiques

  1963cites this paper
• [RESEARCH IN THE BENZOFURAN SERIES. VIII. EFFECTS OF CERTAIN BENZOFURAN DERIVATIVES ON CAPILLARY FRAGILITY AND PERMEABILITY].

  1963cites this paper
• alpha-Pyrone derivatives active in vascular fragility.

  1962cites this paper
• [Bradykinin and anaphylactic reactions in the rabbit].

  1960cites this paper
• [Antagonism between bradykinin and phenylbutazone in the rabbit].

  1960cites this paper
• [A new method for measurement of capillary permeability. Application to the study of the factors of protection (vitamin P) and of the fragilizing factors].

  1959cites this paper
• [Anaphylactic shock in roosters; role of histamine in its onset].

  1958cites this paper
• [Effect of two adrenochrome derivatives on dextran edema in rat].

  1958cites this paper
• The toxicity and metabolism of dihydroquercetin.

  1958cites this paper
• Assay of the capillary action of flavanoid compounds in mice.

  1958cites this paper
• [Anti-allergic actions of heparin].

  1957cites this paper
• Flavonoids in human nutrition and medicine.

  1957cites this paper
• [Histamine liberation from tissues provoked by adrenochrome & its derivatives].

  1957cites this paper
• [Antihistaminic properties of decarboxylated derivatives of cysteine (cysteamine and cystamine)].

  1955cites this paper
• [Effect of rutosides and related substances on purpura induced by croton oil].

  1955cites this paper
• BIOCHEMISTRY OF THE BIOFLAVONOIDS

  1955cites this paper
• Capillary resistance studies. II. Late pregnancy, labour and early puerperium.

  1954cites this paper
• HORMONES CORTICO‐SURRENALIENNES ET ACCROISSEMENT DE LA PERMEABILITE VASCULAIRE PAR ĽHISTAMINE CHEZ LE RAT

  1954cites this paper
• CAPILLARY RESISTANCE STUDIES

  1954cites this paper
• [Experiments on inhibition of inflammatory cutaneous action of chloroform in rat].

  1954cites this paper
• In vivo and in vitro effects of structurally dissimilar hyaluronidase inhibitors.

  1954cites this paper
• [Anti-inflammatory action of cysteinamine and cystinamine].

  1953cites this paper
• [The comparative antiinflammatory action of ACTH, cortisone & sodium salicylate].

  1952cites this paper
• [Chemical and physiological studies on certain soluble hesperidoside derivatives].

  1952cites this paper
• [The local functional physiopathological disturbances caused by mustard gas].

  1952cites this paper
• The biological activity of a flavonoid (vitamin "P") compound.

  1951cites this paper
• The effect of rutin in experimental malignant hypertension.

  1951cites this paper
• [Quantitative studies on the effect and efficacy of antiphlogistic substances].

  1951cites this paper
• Inhibition by rutin of capillary injury by alpha-radiation in rats.

  1951cites this paper
• Mechanism of action of vitamin P flavonoid (rutin) on the cutaneous circulation.

  1951cites this paper
• A study of the Air-blast Method for the Evaluation of the Effectiveness of Flavonoid Compounds on Capillary Fragility

  1950cites this paper
• A quantitative estimation of the effect of rutin on the biological potency of vitamin C.

  1950cites this paper
• Capillary Fragility and Vitamin‘P’Protective Action Against Radiation

  1950cites this paper
• Effect of flavonoid (vitamin P-like) substances on histamine toxicity, anaphylactic shock, histamine-enhanced capillary permeability to dye, and bleeding time; with data on the toxicity of flavonoids.

  1950cites this paper
• The effects of various flavone glucosides on the rate of passage of Evans blue through the damaged capillary wall.

  1949cites this paper
• Effect of Rutin on the Biological Potency of Vitamin C.

  1949cites this paper
• The biochemistry and clinical application of vitamin P.

  1949cites this paper
• Further observations on the effect of rutin and related compounds on cutaneous capillaries.

  1949cites this paper
• Determination of added rutin in urine.

  1949cites this paper
• Peripheral circulation.

  1949cites this paper
• Rutin in Histamine Shock.∗

  1948cites this paper
• The inhibition of the Shwartzman phenomenon by antihistamine and vitamin P-like substances.

  1948cites this paper
• STUDIES ON GANGRENE FOLLOWING COLD INJURY. IX. THE EFFECT OF RUTIN AND OTHER CHEMICAL AGENTS ON THE COURSE OF EXPERIMENTAL FROSTBITE IN RABBITS.

  1948cites this paper
• Effect of rutin on coagulation time of rat blood.

  1948cites this paper
• Antagonism of rutin to capillary effects of sodium bisulfite and procaine.

  1948cites this paper