The control of bone growth by parathyroid hormone, leptin, & statins.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Critical Reviews in Eukaryotic Gene Expression

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1615/CRITREVEUKARYOTGENEEXPR.V12.I1.20PMID 12433064
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.

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• Transactivation of core binding factor alpha1 as a basic mechanism to trigger parathyroid hormone-induced osteogenesis.

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• Leptin reduces ovariectomy-induced bone loss in rats.

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• The Key Role of Caveolin-1 in Estrogen-Mediated Regulation of Endothelial Nitric Oxide Synthase Function in Cerebral Arterioles In vivo

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• Matrix Regulation of Skeletal Cell Apoptosis

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• Activation of STAT proteins and growth control

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• Evidence that anabolic effects of PTH on bone require IGF-I in growing mice.

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• Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.

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• Statins: new drugs for treating osteoporosis?

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• Reconstructing the skeleton with intermittent parathyroid hormone.

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• Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5

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• Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

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• Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors.

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• Statins and bone formation.

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• Leptin: brains and bones

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• Receptors for the carboxyl-terminal region of pth(1-84) are highly expressed in osteocytic cells.

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• Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women

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• Cbfa1 Contributes to the Osteoblast-specific Expression of type I collagen Genes*

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• Treatment with human parathyroid hormone (1-34) for 18 months increases cancellous bone volume and improves trabecular architecture in ovariectomized cynomolgus monkeys (Macaca fascicularis).

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• Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway.

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• Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3*

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• Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation.

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• Leptin Is Expressed in and Secreted from Primary Cultures of Human Osteoblasts and Promotes Bone Mineralization

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• Leptin-Induced Nuclear Translocation of STAT3 Immunoreactivity in Hypothalamic Nuclei Involved in Body Weight Regulation

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• Hydroxy-Methylglutaryl–Coenzyme A Reductase Inhibition Promotes Endothelial Nitric Oxide Synthase Activation Through a Decrease in Caveolin Abundance

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• Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro.

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• Stimulation of Protein Kinase C Activity in Cells Expressing Human Parathyroid Hormone Receptors by C‐ and N‐Terminally Truncated Fragments of Parathyroid Hormone 1–34

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• Inorganic phosphate induces apoptosis of osteoblast-like cells in culture.

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• Parathyroid Hormone Regulation of the Rat Collagenase-3 Promoter by Protein Kinase A-dependent Transactivation of Core Binding Factor α1*

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• Role of Cbfa1 in osteoblast differentiation and function.

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• Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women.

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• The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2.

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• Parathyroid hormone regulates transforming growth factor beta1 and beta2 synthesis in osteoblasts via divergent signaling pathways.

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• Leptin is a potent stimulator of bone growth in ob/ob mice.

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• Changes in Geometry and Cortical Porosity in Adult, Ovary-Intact Rabbits after 5 Months Treatment with LY333334 (hPTH 1-34)

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• Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival.

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• Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.

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• Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation.

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• Fibroblast growth factor-2.

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• Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation.

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• Raloxifene, an oestrogen-receptor modulator, prevents decreased constitutive nitric oxide and vasoconstriction in ovariectomized rats.

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• Tissue engineering via local gene delivery: update and future prospects for enhancing the technology.

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• Nuclear Localization of the Type 1 PTH/PTHrP Receptor in Rat Tissues

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• Caveolin‐Enriched Membrane Signaling Complexes in Human and Murine Osteoblasts

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• Toward a unifying theory of bone remodeling.

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• CBFA1: A molecular switch in osteoblast biology

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• Lactam Formation Increases Receptor Binding, Adenylyl Cyclase Stimulation and Bone Growth Stimulation by Human Parathyroid Hormone (hPTH)(1–28)NH2

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• Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras.

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• Hypothalamic neuropeptide Y and its neuroendocrine regulation by leptin.

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• The central regulation of bone remodeling.

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• Obesity in the new millennium

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• A fundamental transcription factor for bone and cartilage.

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• The developmental control of osteoblast-specific gene expression: role of specific transcription factors and the extracellular matrix environment.

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• Fluctuation of serum leptin level in rats after ovariectomy and the influence of estrogen supplement.

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• Skeletal Unloading Causes Resistance of Osteoprogenitor Cells to Parathyroid Hormone and to Insulin‐like Growth Factor‐I

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• Bisphosphonates Act Directly on the Osteoclast to Induce Caspase Cleavage of Mst1 Kinase during Apoptosis

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• Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.

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• The Nucleolar Targeting Signal (NTS) of Parathyroid Hormone Related Protein Mediates Endocytosis and Nucleolar Translocation

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• Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved.

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• Human Leptin Receptor

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• Leptin receptor (OB‐R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130

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• The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats.

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• Effects of PTH on PTHrP gene expression in human osteoblasts: up-regulation with the kinetics of an immediate early gene.

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