Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells*

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Biological Chemistry

• Publication date

  2002-10-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1074/JBC.M203781200PMID 12149254
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Signal Pathways Involved in Activation of p70S6K and Phosphorylation of 4E-BP1 following Exposure of Multiple Myeloma Tumor Cells to Interleukin-6*

  2002cited by this paper
• HIF-1 and tumor progression: pathophysiology and therapeutics.

  2002cited by this paper
• Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

  2002cited by this paper
• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

  2001cited by this paper
• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

  2001cited by this paper
• FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

  2001cited by this paper
• HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

  2001cited by this paper
• IGF-I receptor signalling in transformation and differentiation

  2001cited by this paper
• Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis.

  2001cited by this paper
• Regulation of translation initiation by FRAP/mTOR.

  2001cited by this paper
• Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.

  2000cited by this paper
• Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis.

  2000cited by this paper
• Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression.

  2000cited by this paper
• Expression of hypoxia‐inducible factor 1α in brain tumors

  2000cited by this paper
• Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein*

  2000cited by this paper
• Distinct Signalling Pathways Mediate Insulin and Phorbol Ester-stimulated Eukaryotic Initiation Factor 4F Assembly and Protein Synthesis in HEK 293 Cells*

  2000cited by this paper
• 'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples.

  2000cited by this paper
• Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.

  2000cited by this paper
• The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.

  2000cited by this paper
• Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

  2000cited by this paper
• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

  1999cited by this paper
• Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.

  1999cited by this paper
• Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo

  1999cited by this paper
• p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1*

  1999cited by this paper
• Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

  1999cited by this paper
• Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein.

  1999cited by this paper
• Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

  1999cited by this paper
• Insulin induces transcription of target genes through the hypoxia‐inducible factor HIF‐1α/ARNT

  1998cited by this paper
• Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.

  1998cited by this paper
• Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.

  1998cited by this paper
• Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

  1998cited by this paper
• HIF‐1α is required for solid tumor formation and embryonic vascularization

  1998cited by this paper
• HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

  1998cited by this paper
• Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

  1997cited by this paper
• Constitutively Active Mutant of the Mitogen-activated Protein Kinase Kinase MEK1 Induces Epithelial Dedifferentiation and Growth Inhibition in Madin-Darby Canine Kidney-C7 Cells*

  1997cited by this paper
• Gene expression profiles in normal and cancer cells.

  1997cited by this paper
• Regulation of eIF-4E BP1 Phosphorylation by mTOR*

  1997cited by this paper
• Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1 in Colorectal Carcinoma*

  1996cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996cited by this paper
• A synthetic inhibitor of the mitogen-activated protein kinase cascade.

  1995cited by this paper
• Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

  1995cited by this paper
• Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

  1994cited by this paper

• Associations between insulin-like growth factor 1, IGF-binding protein 3, and colorectal cancer.

  2026cites this paper
• Beyond mTOR: Unraveling the Complex Pathophysiology and Signaling Pathways in Focal Cortical Dysplasia

  2025cites this paper
• Whole methylomes reveal high-altitude-associated methylation at hypoxia and pigmentation genes in South American Indigenous populations

  2025cites this paper
• Kaempferol promotes apoptosis and inhibits proliferation and migration by suppressing HIF-1α/VEGF and Wnt/β-catenin activation under hypoxic condition in colon cancer

  2025cites this paper
• IGF-1R Inhibitors in Cancer: A Review of Available Evidence and Future Outlook.

  2025cites this paper
• The Mechanisms of Angiogenesis and Apoptosis During the Functional Formation and Regression of the Corpus Luteum in the Ovarian Reproductive Endocrine System

  2025cites this paper
• STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

  2025cites this paper
• Prolyl hydroxylase domain enzymes (isoforms 1-3, PHD1-3), but not factor-inhibiting HIF-1 (FIH-1), interact with the IKK complex and attenuate LPS-activated NF-kappa-B.

  2025cites this paper
• Decoding the mechanisms behind second primary cancers

  2025cites this paper
• Dynamic Regulation of HIF1α and Oxygen-Sensing Factors in Cyclic Bovine Corpus Luteum and During LPS Challenge

  2025cites this paper
• Research progress of hydrogel therapy to improve hypoxic environment of periodontal tissues and promote periodontal regeneration

  2025cites this paper
• Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer

  2025cites this paper
• The growth inhibition of yellow catfish (Pelteobagrus fulvidraco) under long-term low-concentration ammonia stress is regulated by the GH/IGF-1/IGFBP network

  2025cites this paper
• The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and hypoxia-inducible factor 1-alpha

  2024cites this paper
• Heme: A link between hemorrhage and retinopathy of prematurity progression

  2024cites this paper
• Parthenolide Inhibits Synthesis and Promotes Degradation of Programmed Cell Death Ligand 1 and Enhances T Cell Tumor-Killing Activity.

  2024cites this paper
• Serum hypoxia-inducible factor-1 alpha (HIF-1α) and apelin levels in children and adolescents diagnosed with autism spectrum disorder

  2024cites this paper
• Stem cell factor and cKIT modulate endothelial glycolysis in hypoxia.

  2024cites this paper
• Metabolic Roles of HIF1, c-Myc, and p53 in Glioma Cells

  2024cites this paper
• IGF signaling pathway in bone and cartilage development, homeostasis, and disease

  2024cites this paper
• Identification of potential mediators of the relationship between body mass index and colorectal cancer: a Mendelian randomization analysis

  2024cites this paper
• Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma

  2023cites this paper
• Polystyrene nanoplastics inhibit StAR expression by activating HIF-1α via ERK1/2 MAPK and AKT pathways in TM3 Leydig cells and testicular tissues of mice.

  2023cites this paper
• Tumor Hypoxia and Radiotherapy: A Major Driver of Resistance Even for Novel Radiotherapy Modalities.

  2023cites this paper
• PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF‐1α protein stability and gene expression

  2023cites this paper
• Epigallocatechin-3-Gallate Decreases Hypoxia-Inducible Factor-1 in Pancreatic Cancer Cells.

  2023cites this paper
• Non-pituitary GH regulation of the epithelial microenvironment.

  2023cites this paper
• Hypoxia-inducible Factors: Molecular Basis and Clinical Implications

  2023cites this paper
• Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis

  2023cites this paper
• Impact of Intensive Glycemic Treatment on Diabetes Complications—A Systematic Review

  2023cites this paper
• IGF1R and HIF-1α Gene Silencing Inhibits Cancer Cell Growth

  2023cites this paper
• Pleotropic effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors: are they clinically relevant?

  2022cites this paper
• Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism.

  2022cites this paper
• The Insulin-like Growth Factor System and Colorectal Cancer

  2022cites this paper
• Normoxic HIF-1α Stabilization Caused by Local Inflammatory Factors and Its Consequences in Human Coronary Artery Endothelial Cells

  2022cites this paper
• Deregulated transcription factors in cancer cell metabolisms and reprogramming.

  2022cites this paper
• Loss of Heterozygosity for KrasG12D Promotes Malignant Phenotype of Pancreatic Ductal Adenocarcinoma by Activating HIF-2α-c-Myc-Regulated Glutamine Metabolism

  2022cites this paper
• Antioxidant Systems, lncRNAs, and Tunneling Nanotubes in Cell Death Rescue from Cigarette Smoke Exposure

  2022cites this paper
• The Signaling Pathways Associated With Breast Cancer Bone Metastasis

  2022cites this paper
• Propranolol ameliorates retinopathy of prematurity in mice by downregulating HIF-1α via the PI3K/Akt/ERK pathway

  2022cites this paper
• Hypoxia‐induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R

  2022cites this paper
• Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis

  2022cites this paper
• Impact of maternal protein restriction on Hypoxia-Inducible Factor (HIF) expression in male fetal kidney development

  2022cites this paper
• Natural Herbal Medicine as a Treatment Strategy for Myocardial Infarction through the Regulation of Angiogenesis

  2022cites this paper
• Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment

  2022cites this paper
• Hallmarks of cancer: The insulin-like growth factors perspective

  2022influential citation
• Reprogramming of glycolysis by chemical carcinogens during tumor development.

  2022cites this paper
• Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors.

  2022cites this paper
• IGFL2‐AS1‐induced suppression of HIF‐1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9

  2022cites this paper
• The Determinative Role of Cytokines in Retinopathy of Prematurity.

  2022cites this paper
• Inhibition of hypoxia‐induced HIF‐1α‐mediated autophagy enhances the in vitro antitumor activity of rhein in pancreatic cancer cells

  2022cites this paper
• Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

  2021cites this paper
• Early Worsening of Retinopathy in Type 1 and Type 2 Diabetes After Rapid Improvement in Glycaemic Control: A Systematic Review

  2021cites this paper
• Targeting the hallmarks of cancer: the effects of silibinin on proliferation, cell death, angiogenesis, and migration in colorectal cancer

  2021cites this paper
• Transcriptional regulation of HIF1α-mediated STAR expression in murine KK1 granulosa cell line involves cJUN, CREB and CBP-dependent pathways.

  2021cites this paper
• Inhibition of hypoxia-inducible factor-1 by salidroside in an in vitro model of choroidal neovascularization

  2021cites this paper
• GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cells

  2021cites this paper
• PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia

  2021cites this paper
• HIF-1α Metabolic Pathways in Human Cancer.

  2021cites this paper
• Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage

  2021cites this paper
• Study of the Active Components and Molecular Mechanism of Tripterygium wilfordii in the Treatment of Diabetic Nephropathy

  2021cites this paper
• Hypoxia-inducible factor (HIF): fuel for cancer progression.

  2021cites this paper
• Activation of the S100A7/RAGE Pathway by IGF-1 Contributes to Angiogenesis in Breast Cancer

  2021cites this paper
• Comparison of Serum VEGF, IGF-1, and HIF-1α Levels in Children with Autism Spectrum Disorder and Healthy Controls

  2021cites this paper
• Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

  2021cites this paper
• Treatment Strategies Considering Micro-Environment and Clonal Evolution in Multiple Myeloma

  2021cites this paper
• Interfering with Tumor Hypoxia for Radiotherapy Optimization

  2021cites this paper
• Bone marrow-derived humoral factors suppress oxidative phosphorylation, upregulate TSG-6, and improve therapeutic effects on liver injury of mesenchymal stem cells.

  2020cites this paper
• Vitamin D and the insulin-like growth factor system: Implications for colorectal neoplasia.

  2020cites this paper
• Inhibition of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor by Chrysin in a Rat Model of Choroidal Neovascularization

  2020cites this paper
• Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation

  2020cites this paper
• Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.

  2020cites this paper
• LRG1 promotes keratinocyte migration and wound repair through regulation of HIF-1α stability.

  2020cites this paper
• HIF1 driven transcriptional activity regulates steroidogenesis and proliferation of bovine granulosa cells

  2020cites this paper
• Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy

  2020cites this paper
• Impaired Skeletal Muscle Regeneration Induced by Macrophage Depletion could not be Improved by IGF-1 Injection

  2020cites this paper
• Hypoxia modifies the response to flutamide and linuron in male three-spined stickleback (Gasterosteus aculeatus).

  2020cites this paper
• Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis

  2020cites this paper
• Targeting Melanoma Hypoxia with the Food-Grade Lactic Acid Bacterium Lactococcus Lactis

  2020influential citation
• Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine

  2020cites this paper
• Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1α and STAT3 (T705) signaling pathways in hepatic cancer.

  2020cites this paper
• Metastatic TNBC is highly associated with a fused mitochondrial morphology and a glycolytic and lipogenic metabolism programmation.

  2020cites this paper
• Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells

  2020cites this paper
• The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics.

  2020cites this paper
• Potential Role of Glucose Transporter-1 Expression in Gastric Cancer: A Meta-Analysis and Systematic Review

  2020cites this paper
• Modulation of bone turnover aberration: A target for management of primary osteoporosis in experimental rat model

  2020cites this paper
• Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism

  2020cites this paper
• Hypoxia-inducible factor-1α: A promising therapeutic target for vasculopathy in diabetic retinopathy.

  2020cites this paper
• Expression of pro-angiogenic factors as potential biomarkers in experimental models of colon cancer

  2020cites this paper
• Hypoxia and transforming growth factor β1 regulation of long non‐coding RNA transcriptomes in human pulmonary fibroblasts

  2020cites this paper
• Metabolic Plasticity of Melanoma Cells and Their Crosstalk With Tumor Microenvironment

  2020cites this paper
• Mechanisms of hypoxia signalling: new implications for nephrology

  2019cites this paper
• The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

  2019influential citation
• The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased P53/mir-Let-7b Activity.

  2019cites this paper
• Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing

  2019cites this paper
• Activation of HIF-1α by δ-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells

  2019influential citation
• Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas

  2019cites this paper
• The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

  2019influential citation
• A potential function of RLIP76 in the ovarian corpus luteum

  2019cites this paper
• Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines

  2019cites this paper