Role of the Clp System in Stress Tolerance, Biofilm Formation, and Intracellular Invasion in Porphyromonas gingivalis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Bacteriology

• Publication date

  2007-12-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JB.01632-07PMID 18065546PMCID PMC2238200
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of intracellular oral species within human crevicular epithelial cells from subjects with chronic periodontitis by fluorescence in situ hybridization.

  2007cited by this paper
• Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor.

  2007cited by this paper
• Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram‐positive bacteria

  2007cited by this paper
• Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis

  2007cited by this paper
• The Porphyromonas gingivalis clpB gene is involved in cellular invasion in vitro and virulence in vivo.

  2007influential reference
• HtpG, the Porphyromonas gingivalis HSP‐90 homologue, induces the chemokine CXCL8 in human monocytic and microvascular vein endothelial cells

  2007cited by this paper
• A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases

  2006cited by this paper
• Role of the luxS Quorum-Sensing System in Biofilm Formation and Virulence of Staphylococcus epidermidis

  2006cited by this paper
• Self‐compartmentalized bacterial proteases and pathogenesis

  2006cited by this paper
• Role of oxyR in the Oral Anaerobe Porphyromonas gingivalis

  2006cited by this paper
• Osteomyelitis of the Ulna Caused by Porphyromonas gingivalis

  2006cited by this paper
• A universal stress protein of Porphyromonas gingivalis is involved in stress responses and biofilm formation.

  2006cited by this paper
• Detection of bacterial DNA in atheromatous plaques by quantitative PCR.

  2006cited by this paper
• Streptococcus gordonii utilizes several distinct gene functions to recruit Porphyromonas gingivalis into a mixed community

  2006cited by this paper
• Porphyromonas gingivalis Minor Fimbriae Are Required for Cell-Cell Interactions

  2006cited by this paper
• Structural Characterization of Peptide-Mediated Inhibition of Porphyromonas gingivalis Biofilm Formation

  2006cited by this paper
• Porphyromonas gingivalis Genes Involved in Community Development with Streptococcus gordonii

  2006cited by this paper
• Stress Wars: the Direct Role of Host and Bacterial Molecular Chaperones in Bacterial Infection

  2006cited by this paper
• daime, a novel image analysis program for microbial ecology and biofilm research.

  2006cited by this paper
• Superoxide dismutase-encoding gene of the obligate anaerobe Porphyromonas gingivalis is regulated by the redox-sensing transcription activator OxyR.

  2006cited by this paper
• HtrA in Porphyromonas gingivalis can regulate growth and gingipain activity under stressful environmental conditions.

  2006influential reference
• Roles of the Host Oxidative Immune Response and Bacterial Antioxidant Rubrerythrin during Porphyromonas gingivalis Infection

  2006cited by this paper
• Proteomics‐based analysis of a counter‐oxidative stress system in Porphyromonas gingivalis

  2006cited by this paper
• Role of the Porphyromonas gingivalis InlJ Protein in Homotypic and Heterotypic Biofilm Development

  2006cited by this paper
• A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion.

  2006cited by this paper
• Cellular functions, mechanism of action, and regulation of FtsH protease.

  2005cited by this paper
• Differential protein expression by Porphyromonas gingivalis in response to secreted epithelial cell components

  2005cited by this paper
• Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis.

  2005cited by this paper
• Short Fimbriae of Porphyromonas gingivalis and Their Role in Coadhesion with Streptococcus gordonii

  2005cited by this paper
• Oral microbial communities in sickness and in health.

  2005cited by this paper
• clpB, a Novel Member of the Listeria monocytogenes CtsR Regulon, Is Involved in Virulence but Not in General Stress Tolerance

  2004cited by this paper
• Brain abscess in which Porphyromonas gingivalis was detected in cerebrospinal fluid.

  2004cited by this paper
• Alkyl hydroperoxide peroxidase subunit C (ahpC) protects against organic peroxides but does not affect the virulence of Porphyromonas gingivalis W83.

  2004cited by this paper
• Identification of Porphyromonas gingivalis Genes Specifically Expressed in Human Gingival Epithelial Cells by Using Differential Display Reverse Transcription-PCR

  2004cited by this paper
• Glyceraldehyde-3-Phosphate Dehydrogenase of Streptococcus oralis Functions as a Coadhesin for Porphyromonas gingivalis Major Fimbriae

  2004cited by this paper
• Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus

  2004influential reference
• Characterization of Monospecies Biofilm Formation by Helicobacter pylori

  2004cited by this paper
• Control of rpoS transcription in Escherichia coli and Pseudomonas: why so different?

  2003cited by this paper
• Oral microbial heat-shock proteins and their potential contributions to infections.

  2003cited by this paper
• Bacterial invasion by a paracellular route: divide and conquer.

  2003cited by this paper
• Purification, Gene Cloning, Gene Expression, and Mutants of Dps from the Obligate Anaerobe Porphyromonas gingivalis

  2003cited by this paper
• PCR-mediated generation of a gene disruption construct without the use of DNA ligase and plasmid vectors.

  2002cited by this paper
• Role of the Streptococcus gordonii SspB protein in the development of Porphyromonas gingivalis biofilms on streptococcal substrates.

  2002cited by this paper
• Statistical Analysis of Pseudomonas aeruginosa Biofilm Development: Impact of Mutations in Genes Involved in Twitching Motility, Cell-to-Cell Signaling, and Stationary-Phase Sigma Factor Expression

  2002cited by this paper
• Involvement of integrins in fimbriae‐mediated binding and invasion by Porphyromonas gingivalis

  2002cited by this paper
• Regulation and Physiological Significance of ClpC and ClpP in Streptococcus mutans

  2002cited by this paper
• The ClpXP ATP-Dependent Protease Regulates Flagellum Synthesis in Salmonella enterica Serovar Typhimurium

  2002cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Real‐time reverse transcriptase–polymerase chain reaction (RT–PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I

  2001cited by this paper
• Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence of Salmonella enterica Serovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis

  2001cited by this paper
• Discrete Protein Determinant Directs the Species-Specific Adherence of Porphyromonas gingivalis to Oral Streptococci

  2001cited by this paper
• Gene expression in Pseudomonas aeruginosa biofilms

  2001cited by this paper
• SsrA-Mediated Tagging in Bacillus subtilis

  2001cited by this paper
• The Clp Proteases of Bacillus subtilisAre Directly Involved in Degradation of Misfolded Proteins

  2000cited by this paper
• Dental plaque formation.

  2000cited by this paper
• The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes

  2000cited by this paper
• ClpC ATPase Is Required for Cell Adhesion and Invasion of Listeria monocytogenes

  2000cited by this paper
• Heat-inactivated proteins are rescued by the DnaK.J-GrpE set and ClpB chaperones.

  1999cited by this paper
• Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network.

  1999cited by this paper
• Fluorescence image analysis of the association between Porphyromonas gingivalis and gingival epithelial cells

  1999cited by this paper
• Biofilm formation by Porphyromonas gingivalis and Streptococcus gordonii.

  1998cited by this paper
• The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages

  1998cited by this paper
• Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis

  1998cited by this paper
• Life Below the Gum Line: Pathogenic Mechanisms ofPorphyromonas gingivalis

  1998cited by this paper
• Roles of the Escherichia coli Small Heat Shock Proteins IbpA and IbpB in Thermal Stress Management: Comparison with ClpA, ClpB, and HtpG In Vivo

  1998cited by this paper
• Identification of a Streptococcus gordonii SspB domain that mediates adhesion to Porphyromonas gingivalis

  1997cited by this paper
• Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

  1996cited by this paper
• Effect of host responses on the pathogenicity of strains of Porphyromonas gingivalis.

  1996cited by this paper
• The hemagglutinin genes hagB and hagC of Porphyromonas gingivalis are transcribed in vivo as shown by use of a new expression vector

  1996cited by this paper
• Use of a modified Bacteroides-Prevotella shuttle vector to transfer a reconstructed beta-1,4-D-endoglucanase gene into Bacteroides uniformis and Prevotella ruminicola B(1)4

  1996cited by this paper
• Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26 S proteasome.

  1995cited by this paper
• Porphyromonas gingivalis invasion of gingival epithelial cells

  1995influential reference
• The bacterial etiology of destructive periodontal disease: current concepts.

  1992cited by this paper
• The heat-shock protein ClpB in Escherichia coli is a protein-activated ATPase.

  1992cited by this paper
• The Bacterial Etiology of Destructive Periodontal Disease: Current Concepts.

  1992cited by this paper
• Human oral epithelial cell culture I. Improved conditions for reproducible culture in serum-free medium

  1990cited by this paper
• Nutritionally variant streptococci from patients with endocarditis: growth parameters in a semisynthetic medium and demonstration of a chromophore

  1981cited by this paper

• Phage Henu15-resistant mutant derives fitness trade-offs in Morganella morganii.

  2026cites this paper
• Genomic and functional co-diversification imprint African Hominidae microbiomes to signal dietary and lifestyle adaptations

  2025cites this paper
• Single-cell RNA sequencing using split-pool barcoding reveals transcriptional heterogeneity in Porphyromonas gingivalis with implications for periodontal pathogenesis

  2025cites this paper
• Mutations in the clpS Gene of Riemerella anatipestifer Affect Stress Response and Bacterial Virulence

  2025cites this paper
• Alzheimer’s Disease and Porphyromonas gingivalis: Exploring the Links

  2025cites this paper
• Molecular dynamic simulations to assess the structural variability of ClpV from Enterobacter cloacae

  2025cites this paper
• Repurposing Benzbromarone as an Antibacterial Agent against Gram-Positive Bacteria.

  2024cites this paper
• Chicken Juice Enhances C. jejuni NCTC 11168 Biofilm Formation with Distinct Morphological Features and Altered Protein Expression

  2024cites this paper
• Environmental Proteomics Elucidates Phototrophic Biofilm Responses to Ornamental Lighting on Stone-built Heritage

  2024cites this paper
• Dextranase enzyme and Enterococcus faecium probiotic have anti-biofilm effects by reducing the count of bacteria in dental plaque in the oral cavity of dogs.

  2023cites this paper
• Small Molecule Nitazoxanide Inhibits Osteogenic Differentiation and Promotes Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.

  2023cites this paper
• Evolutionary and Pan-genome Analysis of Three Important Black-pigmented Periodontal Pathogens.

  2023cites this paper
• Decoding Acinetobacter baumannii biofilm dynamics and associated protein markers: proteomic and bioinformatics approach

  2022cites this paper
• Proteomic profiling spotlights the molecular targets and the impact of the natural antivirulent umbelliferone on stress response, virulence factors, and the quorum sensing network of Pseudomonas aeruginosa

  2022cites this paper
• ESKAPE Pathogens: Looking at Clp ATPases as Potential Drug Targets

  2022cites this paper
• The Role of ClpB in Bacterial Stress Responses and Virulence

  2021cites this paper
• Caseinolytic Proteins (Clp) in the Genus Klebsiella: Special Focus on ClpK

  2021cites this paper
• The role of uspE in virulence and biofilm formation by Histophilus somni.

  2021cites this paper
• Parasite Survival and Disease Persistence in Cystic Fibrosis, Schistosomiasis and Pathogenic Bacterial Diseases: A Role for Universal Stress Proteins?

  2021cites this paper
• Effect of lon Protease Overexpression on Endotoxin Production and Stress Resistance in Bacillus thuringiensis

  2021cites this paper
• Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens

  2021cites this paper
• Acinetobacter baumannii Strains Deficient in the Clp Chaperone-Protease Genes Have Reduced Virulence in a Murine Model of Pneumonia

  2021cites this paper
• ClpB is an essential stress regulator of Mycobacterium tuberculosis and endows survival advantage to dormant bacilli.

  2020cites this paper
• Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update

  2020cites this paper
• AAA+ Molecular Chaperone ClpB in Leptospira interrogans: Its Role and Significance in Leptospiral Virulence and Pathogenesis of Leptospirosis

  2020cites this paper
• Probiotics alter biofilm formation and the transcription of Porphyromonas gingivalis virulence-associated genes

  2020cites this paper
• Microbial and Host Factors That Affect Bacterial Invasion of the Gingiva

  2020cites this paper
• Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB–DnaK bichaperone system

  2020cites this paper
• Protective Roles of Cytosolic and Plastidal Proteasomes on Abiotic Stress and Pathogen Invasion

  2020cites this paper
• ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis

  2020cites this paper
• Dissociation between the critical role of ClpB of Francisella tularensis for the heat shock response and the DnaK interaction and its important role for efficient type VI secretion and bacterial virulence

  2020cites this paper
• Gene expression of Porphyromonas gingivalis ATCC 33277 when growing in an in vitro multispecies biofilm

  2019cites this paper
• The regulation of Porphyromonas gingivalis biofilm formation by ClpP.

  2019cites this paper
• Physiological significance of ClpP in Enterococcus faecalis and its regulating proteins were identified by Tandem Mass Tag Mass Spectrometry

  2019cites this paper
• Polymicrobial synergy within oral biofilm promotes invasion of dendritic cells and survival of consortia members

  2019cites this paper
• Isolation and Identification of Putative Protein Substrates of the AAA+ Molecular Chaperone ClpB from the Pathogenic Spirochaete Leptospira interrogans

  2018cites this paper
• Characterization and functional analysis of clpB gene from Acidovorax avenae subsp. avenae RS‐1

  2017cites this paper
• Protein Aggregation in Ehrlichia chaffeensis during Infection of Mammalian Cells

  2017cites this paper
• Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial Infection

  2017cites this paper
• Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

  2017cites this paper
• Genes Contributing to Porphyromonas gingivalis Fitness in Abscess and Epithelial Cell Colonization Environments

  2017cites this paper
• New approaches to combat Porphyromonas gingivalis biofilms

  2017cites this paper
• Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans

  2017cites this paper
• Antibiofilm activity of lichen secondary metabolites

  2017cites this paper
• The interaction of Porphyromonas gingivalis with host epithelial cells and its relevance to periodontal disease

  2017cites this paper
• Proteome analysis of Bordetella pertussis isolated from human macrophages.

  2016cites this paper
• ClpP participates in stress tolerance and negatively regulates biofilm formation in Haemophilus parasuis.

  2016cites this paper
• Proteomic and metabolomic profiles demonstrate variation among free-living and symbiotic vibrio fischeri biofilms

  2015cites this paper
• Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants.

  2015cites this paper
• Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design

  2015cites this paper
• Comparative proteomic analysis of Cronobacter sakazakii isolates with different virulences.

  2015cites this paper
• Comment on the paper by Isla et al. (2014).

  2015cites this paper
• Chaperone-assisted protein aggregate reactivation: Different solutions for the same problem.

  2015cites this paper
• Phenotypic and Genotypic Investigation of Persistent Staphylococcus aureus Bacteraemia Isolates

  2015cites this paper
• Non-conventional therapeutics for oral infections

  2015cites this paper
• AAA+ ClpB chaperone as a potential virulence factor of pathogenic microorganisms: Other aspect of its chaperone function

  2014cites this paper
• Characterization of a bacterial tyrosine kinase in Porphyromonas gingivalis involved in polymicrobial synergy

  2014cites this paper
• Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota.

  2014cites this paper
• The role of Porphyromonas gingivalis in the regulation of epithelial-mesenchymal transition markers in migration.

  2014cites this paper
• Effekte von Porphyromonas gingivalis Lipopolysacchariden auf humane Progenitorzellen aus dem dentalen Follikel in vitro

  2014cites this paper
• Oral Community Interactions of Filifactor alocis In Vitro

  2013cites this paper
• Role of TLR2‐dependent IL‐10 production in the inhibition of the initial IFN‐γ T cell response to Porphyromonas gingivalis

  2013cites this paper
• The ClpP Protease Is Required for the Stress Tolerance and Biofilm Formation in Actinobacillus pleuropneumoniae

  2013cites this paper
• Biochemical characterization of the apicoplast-targeted AAA+ ATPase ClpB from Plasmodium falciparum.

  2013cites this paper
• Multiple Single-Cell Genomes Provide Insight into Functions of Uncultured Deltaproteobacteria in the Human Oral Cavity

  2013cites this paper
• Biochemical characterization of the malaria parasite Plasmodium falciparum CLpB homologue PfClpB1 localized to the apicoplast

  2013cites this paper
• to an altered yet protective immune response

  2013cites this paper
• Streptococcus mutans Unique Tandem Repeat Sequence in Is Enhanced by a clpP Transcription of

  2013cites this paper
• Correction: The ClpP Protease Is Required for the Stress Tolerance and Biofilm Formation in Actinobacillus pleuropneumoniae

  2013cites this paper
• Porphyromonas gingivalis displays a competitive advantage over Aggregatibacter actinomycetemcomitans in co-cultured biofilm.

  2013cites this paper
• Infection with Francisella tularensis LVS clpB Leads to an Altered yet Protective Immune Response

  2013cites this paper
• Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis.

  2013cites this paper
• Immune evasion strategies utilized by Francisella tularensis

  2013cites this paper
• Aggregate-Reactivation Activity of the Molecular Chaperone ClpB from Ehrlichia chaffeensis

  2013cites this paper
• Interações de isolados clínicos de Prevotella intermedia e Prevotella nigrescens com Porphyromonas gingivalis na formação de biofilmes.

  2013cites this paper
• Precipitation of Iron on the Surface of Leptospira interrogans Is Associated with Mutation of the Stress Response Metalloprotease HtpX

  2013cites this paper
• Deletion of Lipoprotein PG0717 in Porphyromonas gingivalis W83 Reduces Gingipain Activity and Alters Trafficking in and Response by Host Cells

  2013cites this paper
• Mutations in gltB and gltC reduce oxidative stress tolerance and biofilm formation in Listeria monocytogenes 4b G.

  2013cites this paper
• The clpB gene is involved in the stress response of Myxococcus xanthus during vegetative growth and development.

  2012cites this paper
• MECHANISM OF AGGREGATE REACTIVATION BY THE MOLECULAR CHAPERONE CLPB

  2012cites this paper
• ClpL Is Required for Folding of CtsR in Streptococcus mutans

  2012cites this paper
• Insights into the virulence of oral biofilms: discoveries from proteomics

  2012cites this paper
• Aggregate reactivation mediated by the Hsp100 chaperones.

  2012cites this paper
• Inactivation of clpB in the Pathogen Leptospira interrogans Reduces Virulence and Resistance to Stress Conditions

  2011cites this paper
• Candida albicans enhances invasion of human gingival epithelial cells and gingival fibroblasts by Porphyromonas gingivalis.

  2011cites this paper
• clpB, a class III heat-shock gene regulated by CtsR, is involved in thermotolerance and virulence of Enterococcus faecalis.

  2011cites this paper
• Adaptation and Antibiotic Tolerance of Anaerobic Burkholderia pseudomallei

  2011cites this paper
• SPM43.1 Contributes to Acid-Resistance of Non-Symplasmata-Forming Cells in Pantoea agglomerans YS19

  2011cites this paper
• Time Course of Gene Expression during Porphyromonas gingivalis Strain ATCC 33277 Biofilm Formation

  2011cites this paper
• Bacterial invasion of epithelial cells and spreading in periodontal tissue.

  2010cites this paper
• Community signalling between Streptococcus gordonii and Porphyromonas gingivalis is controlled by the transcriptional regulator CdhR

  2010cites this paper
• Nitrification and degradation of halogenated hydrocarbons—a tenuous balance for ammonia-oxidizing bacteria

  2010cites this paper
• Porphyromonas gingivalis–dendritic cell interactions: consequences for coronary artery disease

  2010cites this paper
• Subgingival biofilm formation.

  2010cites this paper
• Survival of Listeria monocytogenes in Simulated Gastrointestinal System and Transcriptional Profiling of Stress- and Adhesion-Related Genes

  2010cites this paper
• A NOVEL TRANSCRIPTIONAL REGULATOR IN BIOFILM FORMATION IN PORPHYROMONAS GINGIVALIS

  2009cites this paper
• Helicobacter pylori mutants defective in the clpP ATP-dependant protease and the chaperone clpA display reduced macrophage and murine survival.

  2009cites this paper
• Biosynthesis and regulation of cyclic lipopeptides in Pseudomonas fluorescens

  2009cites this paper
• Distinct roles of long/short fimbriae and gingipains in homotypic biofilm development by Porphyromonas gingivalis

  2009cites this paper
• Heat Shock Proteins Are Mediators of Bacterial-Host Interactions

  2009cites this paper