Miltefosine Induces Apoptosis-Like Death in Leishmania donovani Promastigotes

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/AAC.48.3.852-859.2004PMID 14982775PMCID PMC353131
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronic care of HIV and noncommunicable diseases How to leverage tHe HIv experIence

  2012cited by this paper
• Leishmaniasis in HIV infection.

  2003cited by this paper
• Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).

  2003cited by this paper
• Clan CD cysteine peptidases of parasitic protozoa.

  2003cited by this paper
• Characterization and role of protozoan parasite proteasomes.

  2003cited by this paper
• Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda.

  2002cited by this paper
• Increase in Cytosolic Ca2+ Levels through the Activation of Non-selective Cation Channels Induced by Oxidative Stress Causes Mitochondrial Depolarization Leading to Apoptosis-like Death in Leishmania donovaniPromastigotes*

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• On the origin, evolution, and nature of programmed cell death: a timeline of four billion years

  2002cited by this paper
• Programmed cell death in the unicellular protozoan parasite Leishmania

  2002cited by this paper
• On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Cytotoxic Activities of Alkylphosphocholines against Clinical Isolates of Acanthamoeba spp

  2002cited by this paper
• Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?

  2002cited by this paper
• Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.

  2001cited by this paper
• Drug resistance in Indian visceral leishmaniasis

  2001cited by this paper
• Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities.

  2001cited by this paper
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  2001cited by this paper
• Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent.

  2001cited by this paper
• Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes.

  2001cited by this paper
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  2001cited by this paper
• Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons.

  2001cited by this paper
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  2001cited by this paper
• Mechanism of action of anti-proliferative lysophospholipid analogues against the protozoan parasite Trypanosoma cruzi: potentiation of in vitro activity by the sterol biosynthesis inhibitor ketoconazole.

  2001cited by this paper
• Noncaspase proteases in apoptosis

  2000cited by this paper
• Short-course of oral miltefosine for treatment of visceral leishmaniasis.

  2000cited by this paper
• Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania.

  2000cited by this paper
• Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.

  2000cited by this paper
• Effect of the alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi.

  2000cited by this paper
• Identification of Paracaspases and Metacaspases

  2000cited by this paper
• Changes of intracellular calcium, fatty acids and phospholipids during miltefosine-induced apoptosis monitored by fluorescence- and 13C NMR-spectroscopy.

  1999cited by this paper
• Mitochondrial DNA variation of Triatoma infestans populations and its implication on the specific status of T. melanosoma.

  1999cited by this paper
• Reactive oxygen species activate a Ca 2 +-dependent cell death pathway in the unicellular organism Trypanosoma brucei brucei

  1999cited by this paper
• Programmed cell death of the dinoflagellate Peridinium gatunense is mediated by CO(2) limitation and oxidative stress.

  1999cited by this paper
• Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.

  1999cited by this paper
• Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis.

  1999cited by this paper
• Reactive oxygen species activate a Ca2+-dependent cell death pathway in the unicellular organism Trypanosoma brucei brucei.

  1999cited by this paper
• Programmed cell death in procyclic form Trypanosoma brucei rhodesiense --identification of differentially expressed genes during con A induced death.

  1999cited by this paper
• Oral treatment of visceral leishmaniasis with miltefosine.

  1999cited by this paper
• Alkyl-lysophospholipids activate the SAPK/JNK signaling pathway and enhance radiation-induced apoptosis

  1999cited by this paper
• Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors*

  1998cited by this paper
• In vivo antileishmanial activity of hexadecylphosphocholine and other alkylphosphocholines.

  1998cited by this paper
• Apoptotic Effects of Hexadecylphosphocholine on Resistent and Non-Resistant Cells Monitored by NMR Spectroscopy

  1998cited by this paper
• Trial of oral miltefosine for visceral leishmaniasis.

  1998cited by this paper
• The interference effects of hexadecylphosphocholine on proliferation and membrane phospholipid metabolism in human myeloid leukemia cell lines.

  1998cited by this paper
• The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine.

  1998cited by this paper
• Short- and Long-Term Efficacy of Hexadecylphosphocholine against Established Leishmania infantum Infection in BALB/c Mice

  1998cited by this paper
• Induction of Ceramide-mediated Apoptosis by the Anticancer Phospholipid Analog, Hexadecylphosphocholine*

  1998cited by this paper
• A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

  1998cited by this paper
• A DEVD‐Inhibited Caspase Other than CPP32 Is Involved in the Commitment of Cerebellar Granule Neurons to Apoptosis Induced by K+ Deprivation

  1998influential reference
• Caspases: enemies within.

  1998cited by this paper
• Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies.

  1997cited by this paper
• Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis

  1996cited by this paper
• Ether lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmanial alkyl phospholipid analogues.

  1996cited by this paper
• Early stage monitoring of miltefosine induced apoptosis in KB cells by multinuclear NMR spectroscopy.

  1996cited by this paper
• The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei.

  1996cited by this paper
• Leishmaniasis: Public health aspects and control

  1996cited by this paper
• Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival.

  1995cited by this paper
• A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.

  1995cited by this paper
• Uptake, subcellular distribution and metabolism of the phospholipid analogue hexadecylphosphocholine in MDCK cells.

  1994cited by this paper
• Programmed cell death in Dictyostelium.

  1994cited by this paper
• Social controls on cell survival and cell death

  1992cited by this paper
• Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.

  1992cited by this paper
• Hexadecylphosphocholine: oral treatment of visceral leishmaniasis in mice

  1992cited by this paper
• Programmed nuclear death: apoptotic-like degradation of specific nuclei in conjugating Tetrahymena.

  1992cited by this paper
• The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin—Darby canine kidney cells

  1991cited by this paper
• A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.

  1991cited by this paper
• Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients.

  1990cited by this paper
• Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients.

  1990cited by this paper
• Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion

  1987cited by this paper
• The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani.

  1987cited by this paper
• Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

  1980cited by this paper

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  2025cites this paper
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• Unveiling the role of serine o-acetyltransferase in drug resistance and oxidative stress tolerance in Leishmania donovani through the regulation of thiol-based redox metabolism.

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• Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

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• Buparvaquone Induces Ultrastructural and Physiological Alterations Leading to Mitochondrial Dysfunction and Caspase-Independent Apoptotic Cell Death in Leishmania donovani.

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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper