Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Cell

• Publication date

  2001-08-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0092-8674(01)00462-7PMID 11525728
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Three-Dimensional Structure of the p Subunit of E . coli DNA Polymerase Ill Haloenzyme : A Sliding DNA Clamp

  2003influential reference
• Quantum and statistical mechanical studies of liquids. 10. Transferable intermolecular potential functions for water, alcohols, and ethers. Application to liquid water

  2002cited by this paper
• Crystal structure of an archaeal DNA sliding clamp: Proliferating cell nuclear antigen from Pyrococcus furiosus

  2001cited by this paper
• Crystal Structure of the Processivity Clamp Loader Gamma ( ) Complex of E. coli DNA Polymerase III

  2001cited by this paper
• Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III.

  2001cited by this paper
• Mechanism of β Clamp Opening by the δ Subunit ofEscherichia coli DNA Polymerase III Holoenzyme*

  2001cited by this paper
• Unraveling the Mechanism of the Vesicle Transport ATPase NSF, the N-Ethylmaleimide-sensitive Factor*

  2001cited by this paper
• Mechanism of the Sliding @-Clamp of DNA Polymerase I 11 Holoenzyme *

  2001cited by this paper
• Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme.

  2001influential reference
• Tracking sliding clamp opening and closing during bacteriophage T4 DNA polymerase holoenzyme assembly.

  2000cited by this paper
• Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage.

  2000cited by this paper
• The δ Subunit of DNA Polymerase III Holoenzyme Serves as a Sliding Clamp Unloader in Escherichia coli *

  2000cited by this paper
• Sliding clamps: a (tail)ored fit.

  2000cited by this paper
• A Unique Organization of the Protein Subunits of the DNA Polymerase Clamp Loader in the Archaeon Methanobacterium thermoautotrophicum ΔH*

  2000cited by this paper
• AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes.

  1999cited by this paper
• Automated MAD and MIR structure solution

  1999influential reference
• Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex.

  1999influential reference
• The internal workings of a DNA polymerase clamp‐loading machine

  1999cited by this paper
• Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP

  1998cited by this paper
• ATP Binding to the Escherichia coli Clamp Loader Powers Opening of the Ring-shaped Clamp of DNA Polymerase III Holoenzyme*

  1998cited by this paper
• Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998influential reference
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III.

  1997cited by this paper
• Not your average density.

  1997influential reference
• Crystal Structure of the d9 Subunit of the Clamp-Loader Complex of E. coli DNA Polymerase III

  1997cited by this paper
• An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

  1997cited by this paper
• Efficient rebuilding of protein structures.

  1996influential reference
• Structure of the C-Terminal Region of p21 Complexed with Human PCNA

  1996cited by this paper
• Clamp loading, unloading and intrinsic stability of the PCNA, β and gp45 sliding clamps of human, E. coli and T4 replicases

  1996cited by this paper
• Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.

  1996cited by this paper
• Characterization of the five replication factor C genes of Saccharomyces cerevisiae

  1995cited by this paper
• The C-terminal Region of p21 Is Involved in Proliferating Cell Nuclear Antigen Binding but Does Not Appear to Be Required for Growth Inhibition (*)

  1995cited by this paper
• Assembly of a Chromosomal Replication Machine: Two DNA Polymerases, a Clamp Loader, and Sliding Clamps in One Holoenzyme Particle.

  1995cited by this paper
• DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine.

  1995cited by this paper
• A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen.

  1995cited by this paper
• Methodological advances in molecular dynamics simulations of biological systems.

  1995cited by this paper
• Assembly of a Chromosomal Replication Machine: Two DNA Polymerases, a Clamp Loader, and Sliding Clamps in One Holoenzyme Particle.

  1995cited by this paper
• Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA.

  1995cited by this paper
• A second generation force field for the simulation of proteins

  1995influential reference
• AMoRe: an automated package for molecular replacement

  1994cited by this paper
• Smart machines at the DNA replication fork.

  1994cited by this paper
• The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

  1994influential reference
• Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

  1994influential reference
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

  1993cited by this paper
• Homology in accessory proteins of replicative polymerases--E. coli to humans

  1993influential reference
• DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'.

  1993cited by this paper
• Structure and function of the bacteriophage T4 DNA polymerase holoenzyme.

  1992cited by this paper
• Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme.

  1991cited by this paper
• Analysis of the ATPase subassembly which initiates processive DNA synthesis by DNA polymerase III holoenzyme.

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• Molecular dynamics simulations in biology

  1990cited by this paper
• Basic local alignment search tool.

  1990cited by this paper
• ATP interactions of the tau and gamma subunits of DNA polymerase III holoenzyme of Escherichia coli.

  1989cited by this paper
• Two types of replication proteins increase the rate at which T4 DNA polymerase traverses the helical regions in a single-stranded DNA template.

  1981cited by this paper

• How RAG1/2 evolved from ancestral transposases to initiate V(D)J recombination without transposition

  2025cites this paper
• Long-Range Destabilizing Effects of Mutations at the β Clamp Dimer Interface

  2025cites this paper
• Responses to Ligand Binding in the Bacterial DNA Sliding Clamp “β‐Clamp” Manifest in Dynamic Allosteric Effects

  2025cites this paper
• Divide-and-conquer strategy for NMR studies of the E. coli γ-clamp loader complex

  2025influential citation
• How RAG1/2 evolved from ancestral transposases to initiate V(D)J recombination without transposition

  2025cites this paper
• Structure of the PCNA unloader Elg1-RFC

  2024cites this paper
• The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery

  2024influential citation
• Transposition with Tn3-family elements occurs through interaction with the host β-sliding clamp processivity factor

  2024cites this paper
• Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens

  2024influential citation
• Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication

  2024cites this paper
• High‐quality genome of a novel Thermosynechococcaceae species from Namibia and characterization of its protein expression patterns at elevated temperatures

  2024cites this paper
• Differences in clamp loader mechanism between bacteria and eukaryotes

  2023cites this paper
• RecF protein targeting to post-replication (daughter strand) gaps II: RecF interaction with replisomes

  2023cites this paper
• Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli

  2023cites this paper
• Unexpected new insights into DNA clamp loaders

  2022cites this paper
• Mechanistic behavior and subtle key events during DNA clamp opening and closing in T4 bacteriophage.

  2022cites this paper
• From Processivity to Genome Maintenance: The Many Roles of Sliding Clamps

  2022cites this paper
• The partner-swapping sliding clamp loader exposed

  2022cites this paper
• Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis

  2022cites this paper
• Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile.

  2022cites this paper
• Strand discrimination in DNA mismatch repair.

  2021cites this paper
• The Mutant βE202K Sliding Clamp Protein Impairs DNA Polymerase III Replication Activity

  2021cites this paper
• Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

  2021cites this paper
• Potassium Glutamate and Glycine Betaine Induce Self-Assembly of the PCNA and β Sliding Clamps.

  2020cites this paper
• Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch

  2020cites this paper
• Potassium Glutamate and Glycine Betaine Induce Self-Assembly of Sliding Clamps into Higher Order Oligomers

  2020cites this paper
• DNA synthesis: Replication

  2020cites this paper
• DNA Recognition/Processing | DNA Polymerase III, Bacterial

  2020cites this paper
• Co-expression of a functional clamp loader complex in Escherichia coli : construction of an expression operon for the five subunits of human replication factor C

  2019cites this paper
• A general strategy for engineering noncanonical amino acid dependent bacterial growth.

  2019cites this paper
• [The N-Terminal 6 x His Tag on β-clamp Processivity Factor Occludes Gly66 and Affects the Growth of Escherichia coli B834 (DE3) cells].

  2019cites this paper
• A structural view of bacterial DNA replication

  2019cites this paper
• The N-Terminal 6×His Tag on β-Clamp Processivity Factor Occludes Gly66 and Affects the Growth of Escherichia coli B834 (DE3) Cells

  2019cites this paper
• Dynamics of the E. coli β-Clamp Dimer Interface and Its Influence on DNA Loading.

  2019cites this paper
• The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery

  2018cites this paper
• Screening of E. coli β-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization

  2018cites this paper
• Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens.

  2018cites this paper
• Initiation Complex Formation, Mechanism of

  2018cites this paper
• University of Groningen Single-molecule studies of fork dynamics in Escherichia coli DNA replication

  2017cites this paper
• Mechanism of opening a sliding clamp

  2017cites this paper
• Structural dynamics and protein interactions within the E. coli DNA polymerase III holoenzyme

  2017cites this paper
• Cdt1 stabilizes an open MCM ring for helicase loading

  2017cites this paper
• Characterization of a coupled DNA replication and translesion synthesis polymerase supraholoenzyme from archaea

  2017cites this paper
• NMR resonance assignments for the N-terminal domain of the δ subunit of the E. coli γ clamp loader complex

  2017cites this paper
• Structural and Functional Studies of the β2-Sliding Clamp from Pathogenic Bacteria

  2017cites this paper
• Structural insight into β-Clamp and its interaction with DNA Ligase in Helicobacter pylori

  2016cites this paper
• The E. coli DNA Replication Fork.

  2016cites this paper
• Dynamics of Open DNA Sliding Clamps

  2016cites this paper
• Structural Mechanisms of the Sliding Clamp and Sliding Clamp Loader: Insights into Disease and Function: A Dissertation

  2016influential citation
• Investigations into the Architecture and Function of the Bacterial Replisome

  2016cites this paper
• Analysis of the interaction between chromosomal replication and transposition mediated by sliding clamps

  2016cites this paper
• Systems Biology Approaches for the Prediction of Possible Role of Chlamydia pneumoniae Proteins in the Etiology of Lung Cancer

  2016cites this paper
• Solution structure of an "open" E. coli Pol III clamp loader sliding clamp complex.

  2016cites this paper
• Review: The lord of the rings: Structure and mechanism of the sliding clamp loader

  2016cites this paper
• Identification of β Clamp-DNA Interaction Regions That Impair the Ability of E. coli to Tolerate Specific Classes of DNA Damage

  2016cites this paper
• Plasmid replication initiator interactions with origin 13-mers and polymerase subunits contribute to strand-specific replisome assembly

  2015cites this paper
• DNA Polymerase α Subunit Residues and Interactions Required for Efficient Initiation Complex Formation Identified by a Genetic Selection*

  2015cites this paper
• Mechanism of Initiation Complex Formation

  2015cites this paper
• Long-Range PCR Amplification of DNA by DNA Polymerase III Holoenzyme from Thermus thermophilus

  2015cites this paper
• Structural and functional insights into the mechanism of the Pex1/6 complex

  2015cites this paper
• Bacterial DNA Replicases

  2015cites this paper
• cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

  2015cites this paper
• Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

  2014cites this paper
• Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.

  2014cites this paper
• Conserved residues in the delta subunit help the E. coli clamp loader, gamma complex, target primer-template DNA for clamp assembly

  2014cites this paper
• Assembly and Mechanism of Action of Sulfolobus solfataricus DNA Replication Complexes

  2014cites this paper
• DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.

  2014cites this paper
• Intrinsic stability and oligomerization dynamics of DNA processivity clamps

  2014cites this paper
• A dnaN Plasmid Shuffle Strain for Rapid In Vivo Analysis of Mutant Escherichia coli β Clamps Provides Insight Into the Role of Clamp in umuDC-Mediated Cold Sensitivity

  2014cites this paper
• The Roles of UmuD in RegulatingMutagenesis

  2014cites this paper
• Control of Initiation in E. coli

  2014cites this paper
• The interplay of primer-template DNA phosphorylation status and single-stranded DNA binding proteins in directing clamp loaders to the appropriate polarity of DNA

  2014cites this paper
• Diversity of the DNA Replication System in the Archaea Domain

  2014cites this paper
• Modeling Assemblies and Interactions at the Replication Fork: Sliding Clamps and Clamp Interacting Enzymes

  2014cites this paper
• Comparing the mechanism of the E. coli and S. cerevisiae clamp loaders

  2013cites this paper
• Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

  2013cites this paper
• Replication clamps and clamp loaders.

  2013influential citation
• Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain

  2013cites this paper
• Domain Structures and Inter-Domain Interactions Defining the Holoenzyme Architecture of Archaeal D-Family DNA Polymerase

  2013cites this paper
• Insights into the structure and assembly of the Bacillus subtilis clamp-loader complex and its interaction with the replicative helicase

  2013cites this paper
• The molecular basis of LINC complex formation

  2013cites this paper
• The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the β-clamp processivity factor

  2013cites this paper
• Assembly and distributive action of an archaeal DNA polymerase holoenzyme.

  2013cites this paper
• The RFC clamp loader: structure and function.

  2012cites this paper
• The Dynamics of accessory proteins in DNA replication and DNA repair

  2012cites this paper
• Molecular Mechanisms of DNA Polymerase Clamp Loaders

  2012cites this paper
• A Molecular Mechanism Allowing Transposon Tn7 To Target Active Dna Replication

  2012cites this paper
• The harmonic analysis of cylindrically symmetric proteins: a comparison of Dronpa and a DNA sliding clamp.

  2012cites this paper
• M. tuberculosis Sliding β-Clamp Does Not Interact Directly with the NAD+ -Dependent DNA Ligase

  2012cites this paper
• Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target

  2012cites this paper
• The β Sliding Clamp Closes around DNA prior to Release by the Escherichia coli Clamp Loader γ Complex*

  2012cites this paper
• Clamp loader ATPases and the evolution of DNA replication machinery

  2012cites this paper
• DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair.

  2012cites this paper
• The umuD gene products are molecular adaptors in the regulation of DNA damage tolerance

  2012cites this paper
• A phage‐encoded inhibitor of Escherichia coli DNA replication targets the DNA polymerase clamp loader

  2011influential citation
• How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

  2011cites this paper
• Single-molecule and ensemble studies of DNA replication system

  2011cites this paper
• Binding inhibitors of the bacterial sliding clamp by design.

  2011cites this paper
• Replication Factor C Is a More Effective Proliferating Cell Nuclear Antigen (PCNA) Opener than the Checkpoint Clamp Loader, Rad24-RFC*

  2011cites this paper
• Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosis.

  2011cites this paper