DNAM-1 controls NK cell activation via an ITT-like motif

DNAM-1–mediated active biochemical signals initiated by a conserved ITT-like motif are essential for its capacity to enhance NK cell cytotoxicity and cytokine production. Enhancement of these signals may underlie the therapeutic impact of blocking anti-TIGIT antibodies for treatment of cancer and viral infections.

• Publication year

  2015

• Venue

  Journal of Experimental Medicine

• Publication date

  2015-11-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20150792PMID 26552706PMCID 4647266
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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