Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  European Journal of Pharmacology

• Publication date

  2012-09-05

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejphar.2012.05.019PMID 22659112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  1996cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1984cited by this paper
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  1982cited by this paper
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  1982cited by this paper
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  1980cited by this paper
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  1979cited by this paper
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  1979cited by this paper
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  1954cited by this paper
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  1952cited by this paper
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  1951cited by this paper
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