New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biochemistry

• Publication date

  2010-01-26

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/bi9016457PMID 20039683
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oral Antidiabetic Agents

  2012cited by this paper
• Is There a Role for α-Glucosidase Inhibitors in the Prevention of Type 2 Diabetes Mellitus?

  2012cited by this paper
• Nutritional Recommendations for Diabetic Patients and Treatment with α-Glucosidase Inhibitors

  2012cited by this paper
• Drug Therapy of Postprandial Hyperglycaemia

  2012cited by this paper
• Structure proof and synthesis of kotalanol and de-O-sulfonated kotalanol, glycosidase inhibitors isolated from an herbal remedy for the treatment of type-2 diabetes.

  2009cited by this paper
• Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice

  2008cited by this paper
• Mechanistic insights into glycosidase chemistry.

  2008cited by this paper
• On the structure of the bioactive constituent from ayurvedic medicine Salacia reticulata: revision of the literature

  2008cited by this paper
• Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity.

  2008influential reference
• Studies directed toward the stereochemical structure determination of the naturally occurring glucosidase inhibitor, kotalanol: synthesis and inhibitory activities against human maltase glucoamylase of seven-carbon, chain-extended homologues of salacinol.

  2008cited by this paper
• Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit.

  2008cited by this paper
• Zwitterionic glycosidase inhibitors: salacinol and related analogues.

  2007cited by this paper
• New synthetic routes to chain-extended selenium, sulfur, and nitrogen analogues of the naturally occurring glucosidase inhibitor salacinol and their inhibitory activities against recombinant human maltase glucoamylase.

  2007cited by this paper
• New chain-extended analogues of salacinol and blintol and their glycosidase inhibitory activities. Mapping the active-site requirements of human maltase glucoamylase.

  2007cited by this paper
• A new class of glucosidase inhibitor: analogues of the naturally occurring glucosidase inhibitor salacinol with different ring heteroatom substituents and acyclic chain extension.

  2006cited by this paper
• Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives

  2006cited by this paper
• Synthesis of sulfonium sulfate analogues of disaccharides and their conversion to chain-extended homologues of salacinol: new glycosidase inhibitors.

  2006cited by this paper
• Mechanistic and Structural Analysis of a Family 31 α-Glycosidase and Its Glycosyl-enzyme Intermediate*

  2005cited by this paper
• A combined STD-NMR/molecular modeling protocol for predicting the binding modes of the glycosidase inhibitors kifunensine and salacinol to Golgi alpha-mannosidase II.

  2005cited by this paper
• Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate.

  2005cited by this paper
• A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes.

  2005cited by this paper
• Antidiabetogenic constituents from Salacia species

  2005cited by this paper
• Acarbose rearrangement mechanism implied by the kinetic and structural analysis of human pancreatic alpha-amylase in complex with analogues and their elongated counterparts.

  2004cited by this paper
• PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.

  2004cited by this paper
• Potent Glycoside Inhibitors: Transition State Mimics or Simply Fortuitous Binders?

  2004cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Glycosidase inhibitors: update and perspectives on practical use.

  2003cited by this paper
• Is there a role for alpha-glucosidase inhibitors in the prevention of type 2 diabetes mellitus?

  2003cited by this paper
• ARP/wARP and molecular replacement.

  2001influential reference
• A new class of glycosidase inhibitor: synthesis of salacinol and its stereoisomers.

  2001cited by this paper
• A Rational Approach to Drug Therapy of Type 2 Diabetes Mellitus

  2000cited by this paper
• Kotalanol, a Potent α‐Glucosidase Inhibitor with Thiosugar Sulfonium Sulfate Structure, from Antidiabetic Ayurvedic Medicine Salacia reticulata.

  1999cited by this paper
• Safety Profile of Extractive from Trunk of Salacia reticulate (Celastraceae)

  1999cited by this paper
• A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44)

  1999influential reference
• Reassessment of acarbose as a transition state analogue inhibitor of cyclodextrin glycosyltransferase.

  1998cited by this paper
• Salacinol, Potent Antidiabetic Principle with Unique Thiosugar Sulfonium Sulfate Structure from the Ayurvedic Traditional Medicine Salacia reticulata in Sri Lanka and India.

  1998cited by this paper
• Kotalanol, a potent alpha-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata.

  1998cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the Ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Thermodynamics of inhibitor binding to mutant forms of glucoamylase from Aspergillus niger determined by isothermal titration calorimetry.

  1995cited by this paper
• Indian medicinal plants : a compendium of 500 species

  1994cited by this paper
• Pharmacology of alpha-glucosidase inhibition.

  1994cited by this paper
• Indian medicinal plants: a compendium of 500 species. Volume 1.

  1993cited by this paper
• Indian Medicinal Plants: A Compendium of 500 Species

  1993cited by this paper
• Nutritional recommendations for diabetic patients and treatment with alpha-glucosidase inhibitors.

  1992cited by this paper
• Oral hypoglycemic effect of Salacia reticulata in the streptozotocin induced diabetic rat

  1990cited by this paper
• The effect of acarbose and miglitol (BAY-M-1099) on postprandial glucose levels following ingestion of various sources of starch by nondiabetic and streptozotocin-induced diabetic rats.

  1989cited by this paper
• The Metabolic basis of inherited disease

  1989cited by this paper
• MULTIPLICITY OF HUMAN INTESTINAL DISACCHARIDASES. I. CHROMATOGRAPHIC SEPARATION OF MALTASES AND OF TWO LACTASES.

  1965cited by this paper
• The chemistry & pharmacology of Ceylon & Indian medicinal plants

  1935cited by this paper

• In vitro and in silico insights into the comparative bioactivities of Ulva intestinalis (green) and Macrocystis pyrifera (brown) South African Seaweeds in diabesity management

  2026cites this paper
• Anti-diabetic, antioxidants, and molecular docking analysis of isolated essential oils from the East-Bornean endemic ginger, Etlingera balikpapanensis A.D.Poulsen

  2025cites this paper
• Oleanane-Type Glycosides with α‑Glucosidase Inhibitory Activity from Chenopodium serotinum L., an Everlasting Wild Vegetable

  2025cites this paper
• In silico and in vitro evaluation of flavonoid derivatives for diabetes management: molecular dynamics, and enzyme kinetics for pancreatic alpha-amylase and alpha-glucosidase

  2025cites this paper
• In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin

  2025cites this paper
• Natural Proteolytic Peptide Inhibitors of Alpha‐Glucosidase and Alpha‐Amylase as a Strategy to Manage Type 2 Diabetes—A Review

  2025cites this paper
• A study of the mechanism of α-glucosidase inhibition by rapeseed polyphenols

  2025cites this paper
• Antidiabetic potential of Abelmoschus esculentus leaves and fruits: a comparative study assisted by chemical profiling, in vitro and in silico studies

  2025cites this paper
• The First Report on α‐Glucosidase, Tyrosinase, and Free Radical Inhibitory Activities of Pandanus helicopus Kurz Fruits and Their Phytochemicals

  2025cites this paper
• Piperidine-containing drugs and recently studied analogs - biological activity, mechanism of action and synthetic cascade access to their scaffolds.

  2025cites this paper
• In silico and in vivo study: chamazulene and/or cinnamic acid modulate IRS2/GLUT4, HNF4α, GLUT2, redox system, DNA damage, and lipid profile signifying their potential antidiabetic effect

  2025cites this paper
• Synthesis of Neokotalanol and Its Derivatives as Potent α-Glucosidase Inhibitors.

  2025cites this paper
• Comparative Analysis of Mitragynine and Alkaloid Content in Cultivated M. speciosa Leaves and Their α-Glucosidase Inhibitory Activity

  2025influential citation
• Anti-diabetic potentials of L-prolinamides: a computational study

  2025cites this paper
• Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐O‐Benzylidene Acetal Side Chains as Potent α‐Glucosidase Inhibitors

  2025cites this paper
• α‑Glucosidase Inhibitors from the Leaves of Cannabis sativa: Structure–Activity Relationship, Kinetic Investigation, and Molecular Docking

  2025cites this paper
• Invitro Alpha Amylase Inhibitory and Anti- Inflammatory Activity of the Leaves Extract Of Denseflower Knotweed (Persicaria Glabra)

  2025cites this paper
• Exploring the Chemical Profile, Antioxidants, and Anti‐Diabetic Properties of Coffee Beans From Selected East African Countries: A Comparative In Vitro and Computational Study

  2025cites this paper
• Adamantane‐Appended 1,2,3‐Triazole Hybrids: Synthesis and α‐Glucosidase Inhibition Studies through Experimental and In Silico Approach

  2025cites this paper
• Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′-O-Benzylidene Acetal Side Chain Structure as Potent α-Glucosidase Inhibitors

  2025cites this paper
• Phytochemical composition and bioactivity of Debregeasia saeneb leaves: Insights into anti-diabetic and antioxidant properties

  2025cites this paper
• Crystal structure, spectroscopic investigation (FT-IR, NMR, and UV–Vis), DFT calculations, and in vitro antioxidant, α-glucosidase, and α-amylase inhibitor activity determination of the ethyl 1H-imidazole-1-carboxylate molecule and its new synthesized silver perchlorate complex

  2025cites this paper
• Salacia as a functional bioactive food ingredient: Insights into dietary phytonutrients, phytochemistry, health-promoting attributes and innovation potential

  2025cites this paper
• Prominent Antidiabetic and Anticancer Investigation of Scrophularia deserti Extract: Integration of Experimental and Computational Approaches

  2024cites this paper
• In-vitro and in-silico assessment of thiazole-thiazolidinone derivatives as selective inhibitors of urease and α-glucosidase.

  2024cites this paper
• Evaluation of Antioxidant and Anti-Diabetic Potentials of the Ethyl Acetate Leaf Extracts of some Commonly used Medicinal Plants in Ogbomoso, Nigeria

  2024cites this paper
• Phytochemical Profiling and Therapeutic Potential of Abelmoschus esculentus Fruit Extracts: Insights Into Antidiabetic Potential in In Vitro and In Vivo Experiments

  2024cites this paper
• Advancements in Computational Approaches for Antidiabetic Drug Discovery: A Review.

  2024cites this paper
• Exploring the inhibitory action of betulinic acid on key digestive enzymes linked to diabetes via in vitro and computational models: approaches to anti-diabetic mechanisms

  2024cites this paper
• A method for evaluating the risks of glucose dysregulation in daily life by continuous measurement of glucose excursions under reduced glycemic load: a pilot study

  2024cites this paper
• Plant Extracts for Type 2 Diabetes: Mechanisms, Clinical Implications and Future Directions—A Systematic Review

  2024cites this paper
• Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes

  2024cites this paper
• Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor

  2024cites this paper
• Enzymes inhibitory capabilities of phenolics from Plumbago indica L. and Plumbago auriculata Lam.: In-vitro studies and molecular docking

  2024cites this paper
• A Comprehensive Review of Salacia reticulata: Botanical, Ethnomedicinal, Phytochemical, and Pharmacological Insights

  2023cites this paper
• Profiling Of Volatiles In Tissues Of Salacia Reticulata Wight. With Anti-Diabetic Potential Using GC-MS And Molecular Docking

  2023cites this paper
• Increased yield of 2‐O‐α‐d‐glucopyranosyl‐l‐ascorbic acid synthesis by α‐glucosidase using rational design that regulating the ground state of enzyme and substrate complex

  2023cites this paper
• Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies

  2023cites this paper
• Blood glucose lowering and anti-oxidant potential of erythritol: An in vitro and in vivo study

  2023cites this paper
• Design and Synthesis of Sulfonium Derivatives: A Novel Class of α-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities.

  2023cites this paper
• α-amylase activities of fraction in dichloromethane extract from the stem bark of Garcinia forbesii

  2023cites this paper
• Pyrazole scaffold‐based derivatives: A glimpse of α‐glucosidase inhibitory activity, SAR, and route of synthesis

  2023cites this paper
• Advances in the natural α‐glucosidase inhibitors

  2023cites this paper
• Activity-based investigation of the possible anti-diabetic potentials of some Nigerian medicinal plants

  2023cites this paper
• In-vitro, in-silico studies on the proposed penasulfate A and its derivatives as dual inhibitors of a-glucosidases and human cancer cells

  2023cites this paper
• Herbal tea, a novel adjuvant therapy for treating type 2 diabetes mellitus: A review

  2022cites this paper
• Chemical Profiling and Molecular Docking Study of Agathophora alopecuroides

  2022cites this paper
• Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

  2022cites this paper
• Synthetic studies on naturally occurring sulfonium-type α-glucosidase inhibitors: progress and perspective

  2022cites this paper
• Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives

  2022cites this paper
• Structural basis for proteolytic processing of Aspergillus sojae α-glucosidase L with strong transglucosylation activity.

  2022cites this paper
• Salicylic acid derivatives as potential α-glucosidase inhibitors: drug design, molecular docking and pharmacokinetic studies

  2022cites this paper
• In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

  2022cites this paper
• Investigation of effective natural inhibitors for starch hydrolysing enzymes from Simaroubaceae plants by molecular docking analysis and comparison with in-vitro studies

  2022cites this paper
• Chemical Group Profiling, In Vitro and In Silico Evaluation of Aristolochia ringens on α-Amylase and α-Glucosidase Activity

  2021cites this paper
• Cytotoxic and α‐Glucosidase Inhibitory Xanthones from Garcinia mckeaniana Leaves and Molecular Docking Study

  2021cites this paper
• Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function.

  2021cites this paper
• Antioxidative and α-glucosidase inhibitory constituents of Polyscias guilfoylei: experimental and computational assessments

  2021cites this paper
• Studies on Molecular Docking of Moringa Oleifera Leaf Phytochemical Constituents on Alpha Glucosidase, Alpha Amylase and Dipeptidyl Peptidase

  2021cites this paper
• Identification of raloxifene as a novel α-glucosidase inhibitor using a systematic drug repurposing approach in combination with cross molecular docking-based virtual screening and experimental verification.

  2021cites this paper
• A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia

  2021cites this paper
• Evaluation of the inhibitory potentials of selected compounds from Costus spicatus (Jacq.) rhizome towards enzymes associated with insulin resistance in polycystic ovarian syndrome: an in silico study

  2021cites this paper
• Synthetic access to thiolane-based therapeutics and biological activity studies.

  2021cites this paper
• Targeting N-Terminal Human Maltase-Glucoamylase to Unravel Possible Inhibitors Using Molecular Docking, Molecular Dynamics Simulations, and Adaptive Steered Molecular Dynamics Simulations

  2021influential citation
• Structure–activity relationships of pancreatic α-amylase and α-glucosidase as antidiabetic targets

  2021cites this paper
• In vitro and in silico studies of fluorinated 2,3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents

  2021cites this paper
• The antioxidant and antidiabetic potentials of polyphenolic-rich extracts of Cyperus rotundus (Linn.)

  2021cites this paper
• Flavonoids as potential agents in the management of type 2 diabetes through the modulation of α-amylase and α-glucosidase activity: a review

  2021cites this paper
• Novel amine-functionalized benzimidazolium salts: Synthesis, characterization, bioactivity, and molecular docking studies

  2020cites this paper
• Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia," against human intestinal maltase.

  2020cites this paper
• Natural and synthetic sugar mimics

  2020cites this paper
• Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase enzymes.

  2020cites this paper
• Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function

  2020cites this paper
• Chemical profiling of secondary metabolites from Himatanthus drasticus (Mart.) Plumel latex with inhibitory action against the enzymes α-amylase and α-glucosidase: In vitro and in silico assays.

  2020cites this paper
• Anti-Diabetic Potential of Anti-Oxidant Compounds "Riboflavin, Flavin Mononucleotide and Flavin Adenine Dinucleotide" with High Therapeutic Potency through Inhibition of α-Amylase and α-Glucosidase Enzymes at Sub-Micromolar Concentrations

  2020cites this paper
• α-Amylase Inhibition, Antioxidant Activity and Phytochemical Analysis of Calotropis gigantea (L.) Dryand

  2020cites this paper
• Computational and structural biology of α-glucosidase-inhibitor complexes: clues to drug optimization and development

  2020cites this paper
• Charge assisted chalcogen bonds: CSD and DFT analyses and biological implication in glucosidase inhibitors.

  2020cites this paper
• A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine

  2020cites this paper
• Recent Progress in Construction of Natural De-O-sulfonated Sulfonium Sugars with Antidiabetic Activities.

  2019cites this paper
• Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes.

  2019cites this paper
• Practical Route to Neokotalanol and Its Natural Analogues: Sulfonium Sugars with Antidiabetic Activities.

  2019cites this paper
• Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity.

  2019cites this paper
• Proteins with Evolutionarily Hypervariable Domains are Associated with Immune Response and Better Survival of Basal-like Breast Cancer Patients

  2019cites this paper
• Investigation on the Enzymatic Profile of Mulberry Alkaloids by Enzymatic Study and Molecular Docking

  2019cites this paper
• Facile Synthesis of Neokotalanol, a Potent α-glycosidase Inhibitor Isolated from the Ayurvedic Traditional Medicine “Salacia”

  2019cites this paper
• Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies.

  2019cites this paper
• In the Search of Glycoside-Based Molecules as Antidiabetic Agents

  2019cites this paper
• Total Synthesis of the Proposed Structure of Penasulfate A: l-Arabinose as a Source of Chirality.

  2019cites this paper
• Maltase-glucoamylase inhibition potency and cytotoxicity of pyrimidine-fused compounds: An in silico and in vitro approach

  2019cites this paper
• Inhibitory effects of selected antibiotics on the activities of α-amylase and α-glucosidase: In-vitro, in-vivo and theoretical studies.

  2019cites this paper
• MiR-26a and miR-26b downregulate the expression of sucrase-isomaltase enzyme: A new chapter in diabetes treatment.

  2019cites this paper
• GC-MS Analysis and Inhibitory Evaluation of Terminalia catappa Leaf Extracts on Major Enzymes Linked to Diabetes

  2019cites this paper
• In Silico Docking Analysis of A-type Proanthocyanidins to α-Glucosidase Constructed by Correlation with in Vitro Bioassay

  2019cites this paper
• Discrimination of Curcuma species and bioactivity correlation using NMR-based metabolomics approach and synthesis of curcumin analogs

  2018cites this paper
• TM IN VITRO STUDIES ON ALPHA AMYLASE INHIBITORY ACTIVITY OF INDIAN MEDICINAL PLANTS

  2018cites this paper
• A Review of Α-Glucosidase and Α-Amylase Inhibitors for Type 2 Diabetes Isolated From Some Important Indian Medicinal Plants

  2018cites this paper
• Development of a Web-Server for Identification of Common Lead Molecules for Multiple Protein Targets

  2018cites this paper
• Crystallization and Biological Studies of Nypa fruticans Wurmb Sap

  2018cites this paper
• herbal treatment for type 2 diabetes compared to current medicines

  2018cites this paper