Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Science

• Publication date

  1996-09-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/science.273.5283.1864PMID 8791592
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD40 ligand is required for protective cell-mediated immunity to Leishmania major.

  1996cited by this paper
• Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice.

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• Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

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• Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals.

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• The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells

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• CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

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• Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity.

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