Structural brain anomalies and chronic pain: a quantitative meta-analysis of gray matter volume.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Pain

• Publication date

  2013-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jpain.2013.03.001PMID 23685185PMCID PMC4827858
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Minimizing within‐experiment and within‐group effects in activation likelihood estimation meta‐analyses

  2012cited by this paper
• Brain structure anomalies in autism spectrum disorder—a meta‐analysis of VBM studies using anatomic likelihood estimation

  2012cited by this paper
• Changes in regional gray matter volume in women with chronic pelvic pain: A voxel‐based morphometry study

  2012cited by this paper
• Activation likelihood estimation meta-analysis revisited

  2012cited by this paper
• Structural changes of the brain in rheumatoid arthritis.

  2012cited by this paper
• Changes in regional gray and white matter volume in patients with myofascial-type temporomandibular disorders: a voxel-based morphometry study.

  2011cited by this paper
• Handbook of Physiology; a Critical, Comprehensive Presentation of Physiological Knowledge and Concepts

  2011cited by this paper
• Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain

  2011cited by this paper
• Pain is associated with regional grey matter reduction in the general population

  2011cited by this paper
• Different Pain, Different Brain: Thalamic Anatomy in Neuropathic and Non-Neuropathic Chronic Pain Syndromes

  2011cited by this paper
• Structural Brain Imaging: A Window into Chronic Pain

  2011cited by this paper
• Progressive pathology is functionally linked to the domains of language and emotion: meta-analysis of brain structure changes in schizophrenia patients

  2011cited by this paper
• Cortical thickness and pain sensitivity in zen meditators.

  2010cited by this paper
• Brain morphological changes associated with cyclic menstrual pain

  2010cited by this paper
• Neuroimaging in chronic migraine

  2010cited by this paper
• Comparison of the disparity between Talairach and MNI coordinates in functional neuroimaging data: Validation of the Lancaster transform

  2010cited by this paper
• Chronic myofascial temporomandibular pain is associated with neural abnormalities in the trigeminal and limbic systems

  2010cited by this paper
• Pain imaging in health and disease--how far have we come?

  2010cited by this paper
• Graded cutaneous electrical vs thermal stimulation in humans shows different insular and cingulate cortex activation

  2010cited by this paper
• Altered Regional Brain Morphology in Patients With Chronic Facial Pain

  2010cited by this paper
• Long‐term depression of pain‐related cerebral activation in healthy man: An fMRI study

  2010cited by this paper
• Regional gray matter density changes in brains of patients with irritable bowel syndrome.

  2010cited by this paper
• Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study.

  2010cited by this paper
• Patients With Pain Disorder Show Gray-Matter Loss in Pain-Processing Structures: A Voxel-Based Morphometric Study

  2009cited by this paper
• Changes in brain function and morphology in patients with recurring herpes simplex virus infections and chronic pain

  2009cited by this paper
• Coordinate‐based activation likelihood estimation meta‐analysis of neuroimaging data: A random‐effects approach based on empirical estimates of spatial uncertainty

  2009cited by this paper
• Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain

  2009cited by this paper
• Regional fMRI brain activation does correlate with global brain volume.

  2009cited by this paper
• Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions.

  2009cited by this paper
• Imaging the relationship between structure, function and behaviour in the human brain

  2009cited by this paper
• Perception and suppression of thermally induced pain: A fMRI study

  2009cited by this paper
• Subtle Grey Matter Changes Between Migraine Patients and Healthy Controls

  2008cited by this paper
• Chronic pain may change the structure of the brain.

  2008cited by this paper
• The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions.

  2008cited by this paper
• Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis.

  2008cited by this paper
• Chronic pain is associated with brain volume loss in older adults: preliminary evidence.

  2008cited by this paper
• Common chronic pain conditions in developed and developing countries: gender and age differences and comorbidity with depression-anxiety disorders.

  2008cited by this paper
• Gray Matter Increase Induced by Practice Correlates with Task-Specific Activation: A Combined Functional and Morphometric Magnetic Resonance Imaging Study

  2008cited by this paper
• Advances in brain imaging of neuropathic pain.

  2008cited by this paper
• Variations in brain volume and regional morphology associated with chronic pain

  2008cited by this paper
• Increased gray matter density in young women with chronic vulvar pain

  2008cited by this paper
• Cortical correlates of perception and suppression of electrically induced pain

  2007cited by this paper
• Voxel‐Based Morphometry Reveals Gray Matter Abnormalities in Migraine

  2007cited by this paper
• Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia

  2007cited by this paper
• Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?

  2007cited by this paper
• BrainMap

  2007cited by this paper
• Attention and reality constraints on the neural processes of empathy for pain

  2007cited by this paper
• Influence of Continual Biofeedback on Jaw Pursuit-Tracking in Healthy Adults and in Adults With Apraxia Plus Aphasia

  2007cited by this paper
• Striatal grey matter increase in patients suffering from fibromyalgia – A voxel‐based morphometry study

  2007cited by this paper
• Brain Gray Matter Changes in Migraine Patients With T2-Visible Lesions: A 3-T MRI Study

  2006cited by this paper
• Contingency awareness in human aversive conditioning involves the middle frontal gyrus

  2006cited by this paper
• Anterolateral Prefrontal Cortex Mediates the Analgesic Effect of Expected and Perceived Control over Pain

  2006cited by this paper
• Functions of the left superior frontal gyrus in humans: a lesion study.

  2006cited by this paper
• When the brain loses its self: prefrontal inactivation during sensorimotor processing.

  2006cited by this paper
• Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients

  2006cited by this paper
• Gray matter decrease in patients with chronic tension type headache

  2005cited by this paper
• Pain and emotion interactions in subregions of the cingulate gyrus

  2005cited by this paper
• What is the role of muscle receptors in proprioception?

  2005cited by this paper
• Human brain mechanisms of pain perception and regulation in health and disease

  2005cited by this paper
• ALE meta‐analysis: Controlling the false discovery rate and performing statistical contrasts

  2005cited by this paper
• Nociceptive processing in the human brain.

  2005cited by this paper
• Fine-tuning of auditory cortex during speech production.

  2005cited by this paper
• Evidence of augmented central pain processing in idiopathic chronic low back pain.

  2004cited by this paper
• Sensory and affective aspects of pain perception: is medial thalamus restricted to emotional issues?

  2004cited by this paper
• Chronic pain patients are impaired on an emotional decision‐making task

  2004cited by this paper
• Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter Density

  2004cited by this paper
• Pain catastrophizing and neural responses to pain among persons with fibromyalgia.

  2004cited by this paper
• Suppressed responses to self-triggered sounds in the human auditory cortex.

  2004cited by this paper
• Somatotopic representation of nociceptive information in the putamen: an event-related fMRI study.

  2004cited by this paper
• Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation.

  2003cited by this paper
• The neural correlates of perceiving one's own movements

  2003cited by this paper
• Cognitive impairment in patients with chronic pain: The significance of stress

  2003cited by this paper
• Imaging how attention modulates pain in humans using functional MRI.

  2002cited by this paper
• Modulation of the Auditory Cortex during Speech: An MEG Study

  2002cited by this paper
• Towards a neural basis of auditory sentence processing.

  2002cited by this paper
• Event-Related Functional MRI Study on Central Representation of Acute Muscle Pain Induced by Electrical Stimulation

  2002cited by this paper
• Mapping context and content: the BrainMap model

  2002cited by this paper
• Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation.

  2002cited by this paper
• Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia.

  2002cited by this paper
• Meta-Analysis of the Functional Neuroanatomy of Single-Word Reading: Method and Validation

  2002cited by this paper
• Sustained Mnemonic Response in the Human Middle Frontal Gyrus during On-Line Storage of Spatial Memoranda

  2002cited by this paper
• Role of left posterior superior temporal gyrus in phonological processing for speech perception and production

  2001cited by this paper
• Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

  2001cited by this paper
• Brain mechanisms for reading: the role of the superior temporal gyrus in word and pseudoword naming

  2000cited by this paper
• Automated Talairach Atlas labels for functional brain mapping

  2000cited by this paper
• Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study

  2000cited by this paper
• A functional magnetic resonance imaging study of the role of left posterior superior temporal gyrus in speech production: implications for the explanation of conduction aphasia.

  2000cited by this paper
• Psychological and neural mechanisms of the affective dimension of pain.

  2000cited by this paper
• Auditory cortex on the human posterior superior temporal gyrus

  2000cited by this paper
• The cortical representation of pain.

  1999cited by this paper
• Region‐specific encoding of sensory and affective components of pain in the human brain: A positron emission tomography correlation analysis

  1999cited by this paper
• Pain: an overview

  1999cited by this paper
• Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study

  1999cited by this paper
• Dissociating pain from its anticipation in the human brain.

  1999cited by this paper
• Pain – an overview

  1999cited by this paper
• Temporal and intensity coding of pain in human cortex.

  1998cited by this paper
• The structural components of music perception. A functional anatomical study.

  1997cited by this paper
• Pain affect encoded in human anterior cingulate but not somatosensory cortex.

  1997cited by this paper
• Automated labeling of the human brain: A preliminary report on the development and evaluation of a forward‐transform method

  1997cited by this paper
• Sense of effort and the effects of fatigue in the tongue and hand.

  1996cited by this paper

• Association of brain cortical changes with efficacy of treatment in patients with chronic neck and shoulder pain: a longitudinal surface-based morphometry study

  2026cites this paper
• Association of sexual dysfunctions according to DSM-5 criteria with structural brain differences in women and men from the Hamburg City Health Study

  2026cites this paper
• Neuroimaging Analysis of Patients With Anterior Cruciate Ligament Reconstruction: Pain-Driven Inhibition of Return to Sports.

  2026cites this paper
• Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia

  2025cites this paper
• Nociplastic pain: an introduction.

  2025cites this paper
• Investigating the therapeutic potential of epigallocatechin gallate (EGCG) for chronic pain management: Mechanisms, applications, and future perspectives.

  2025cites this paper
• Convergent structural brain alterations in chronic pain: A multi-metric individual participant data meta-analysis

  2025cites this paper
• Cortical reorganization in neuropathic pain due to peripheral nerve degeneration: altered cortical surface morphometry and hierarchical topography.

  2025cites this paper
• Neural circuit for Non-Suicidal Self-Injury and Causal Clinical Validation.

  2025cites this paper
• The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.

  2025cites this paper
• Aberrant functional connectivity patterns in the pregenual anterior cingulate cortex and anterior midcingulate cortex of patients with irritable bowel syndrome accompanied by depressive symptoms

  2025cites this paper
• Altered gray matter volume in chronic temporomandibular disorder pain with pain catastrophizing: a voxel-based morphometry study

  2025cites this paper
• Chronic pain and its association with cognitive decline and brain function abnormalities in older adults: Insights from EEG and neuropsychological assessment.

  2025cites this paper
• Fibromyalgia in the Era of Brain PET/CT Imaging

  2025cites this paper
• Revisiting the interplay of pain and perception: A commentary on "Chronic pain and subjective memory problems are dynamic risk factors for functional decline".

  2025cites this paper
• The Activation of Hippocampal Microglial Cells and Their Role in the Regulation of Pain.

  2025cites this paper
• Assessing the Modulatory Effects of tDCS and Acupuncture on Cerebral Blood Flow in Chronic Low Back Pain Using Arterial Spin Labeling Perfusion Imaging

  2025cites this paper
• Neuroplasticity in chronic pain: insights into diagnosis and treatment

  2025cites this paper
• Chronic pain in multiple sites is associated with depressive symptoms in US adults: A cross-sectional study.

  2025cites this paper
• Hippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study

  2025cites this paper
• 16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomized controlled trial

  2025cites this paper
• Spatiotemporal Gray Matter Plasticity During Chronification of Preclinical Neuropathic Pain

  2025cites this paper
• Dissecting the neurogenetic architecture of chronic pain: a brain-wide genetics study.

  2025cites this paper
• The causal role of brain circuits in osteoarthritis pain

  2025cites this paper
• The Antinociceptive Effects and Sex-Specific Neurotransmitter Modulation of Metformin in a Mouse Model of Fibromyalgia

  2024cites this paper
• The effects of virtual reality neuroscience-based therapy on clinical and neuroimaging outcomes in patients with chronic back pain: a randomized clinical trial.

  2024cites this paper
• Fractal Similarity of Pain Brain Networks.

  2024cites this paper
• The brain's duck test in phantom percepts: Multisensory congruence in neuropathic pain and tinnitus.

  2024cites this paper
• Pain resilience dimensions and regional gray matter volume as risk factors for poor outcomes of chronic pain: a prospective cohort study

  2024cites this paper
• Comparison of patients with chronic and episodic migraine with healthy individuals by brain volume and cognitive functions

  2024cites this paper
• Can a specific biobehavioral-based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial

  2024cites this paper
• The Relationship Between Pain and Interoception: A Systematic Review and Meta-Analysis.

  2024cites this paper
• Neuroplasticity of the white matter tracts underlying recovery of diarrhea-predominant irritable bowel syndrome following acupuncture treatment

  2024cites this paper
• Electroacupuncture Mitigates TRPV1 Overexpression in the Central Nervous System Associated with Fibromyalgia in Mice

  2024cites this paper
• From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?

  2024cites this paper
• Volume changes of deep brain structures in episodic migraine

  2024cites this paper
• The neural basis linking threat appraisal and pain outcomes in chronic pain: Roles of the left DLPFC and PCC

  2024cites this paper
• Chronic Widespread Pain

  2024cites this paper
• Differential DNA methylation profiles of Alzheimer's disease-related genomic pathways in the blood of cognitively-intact individuals with and without high impact chronic pain

  2024cites this paper
• Chronic pain-induced functional and structural alterations in the brain: a multi-modal meta-analysis.

  2024cites this paper
• ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain

  2024cites this paper
• Reduced gray matter volume and cortical thickness in patients with Small-Fiber Neuropathy.

  2024cites this paper
• Functional and Structural Abnormalities in the Pain Network of Generalized Anxiety Disorder Patients with Pain Symptoms.

  2024cites this paper
• Associations Between Adolescent Pain and Psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study

  2023cites this paper
• The effects of physical exercise on structural, functional, and biochemical brain characteristics in individuals with chronic whiplash‐associated disorder: A pilot randomized clinical trial

  2023cites this paper
• The Biology of Pain: Through the Rheumatology Lens

  2023cites this paper
• A perspective on a precision approach to pain in cancer; moving beyond opioid therapy

  2023cites this paper
• Can a specific biobehavioral based therapeutic education program lead to changes in pain perception and brain plasticity biomarkers in chronic pain patients? A study protocol for a randomized clinical trial.

  2023cites this paper
• Classification and Diagnosis of Temporomandibular Disorders and Temporomandibular Disorder Pain.

  2023cites this paper
• Gray matter alterations and pain-related emotional processing in patients with adenomyosis-associated dysmenorrhea: a neuroimaging perspective

  2023cites this paper
• The waiting game: investigating the neurobiological transition from acute to persistent pain in adolescent rats

  2023influential citation
• Fibromyalgia is associated with hypersensitivity but not with abnormal pain modulation: evidence from QST trials and spinal fMRI

  2023cites this paper
• Reduced cingulate gyrus volume in Cavalier King Charles Spaniels with syringomyelia and neuropathic pain revealed by voxel-based morphometry: a pilot study

  2023cites this paper
• The Effects of Virtual Reality Neuroscience-based Therapy on Clinical and Neuroimaging Outcomes in Patients with Chronic Back Pain: A Randomized Clinical Trial

  2023cites this paper
• Limbic system plasticity after electroacupuncture intervention in knee osteoarthritis rats.

  2023cites this paper
• A multimodal meta-analysis of gray matter alterations in trigeminal neuralgia

  2023cites this paper
• Retrograde inhibition of hyperactive central pathways in nociplastic pain

  2023cites this paper
• Menstrually-related migraine shapes the structural similarity network integration of brain.

  2023cites this paper
• Brain morphology predicts individual sensitivity to pain: a multicenter machine learning approach

  2023cites this paper
• Decreased gray matter volume in regions associated with affective pain processing in unmedicated individuals with nonsuicidal self-injury.

  2023cites this paper
• Differential Structural Brain Changes Between Responders and Nonresponders After Physical Exercise Therapy for Chronic Nonspecific Neck Pain

  2023cites this paper
• The Neurophysiological Lesion: A Scoping Review.

  2023cites this paper
• Clinical relevance of resistance training in women with fibromyalgia: A systematic review and meta‐analysis

  2023cites this paper
• Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain

  2023cites this paper
• Fibromyalgia predicts increased odds of pain-related addiction exacerbation among individuals with pain and opioid use disorder

  2023cites this paper
• Effect of exercise on chronic neck pain and central sensitization: A protocol for a randomized crossover trial

  2023cites this paper
• Endometriosis, psychiatric comorbidities and neuroimaging: Estimating the odds of an endometriosis brain.

  2022cites this paper
• Associations between pain catastrophizing and resting‐state functional brain connectivity: Ethnic/race group differences in persons with chronic knee pain

  2022cites this paper
• Mid-term improvement of cognitive performance after total hip arthroplasty in patients with osteoarthritis of the hip

  2022cites this paper
• Differences in Structural Brain Characteristics Between Individuals with Chronic Nonspecific Neck Pain and Asymptomatic Controls: A Case–Control Study

  2022influential citation
• Revealing the Selectivity of Neuroanatomical Alteration in Autism Spectrum Disorder via Reverse Inference.

  2022cites this paper
• Cerebral perfusion alterations in patients with trigeminal neuralgia as measured by pseudo-continuous arterial spin labeling

  2022cites this paper
• Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain

  2022cites this paper
• Human lesions and animal studies link the claustrum to perception, salience, sleep and pain

  2022cites this paper
• Detangling the structural neural correlates associated with resting versus dynamic phantom limb pain intensity using a voxel-based morphometry analysis.

  2022cites this paper
• Pain and cognitive performance in adults with multiple sclerosis: A systematic review

  2022influential citation
• Chronic anemia: The effects on the connectivity of white matter

  2022cites this paper
• Morphological and functional brain changes in chronic cancer‐related pain: A systematic review

  2022cites this paper
• The relationship between Central Nervous System morphometry changes and key symptoms in Crohn’s disease

  2022cites this paper
• Pain, But Not Physical Activity, Is Associated with Gray Matter Volume Differences in Gulf War Veterans with Chronic Pain

  2022cites this paper
• Reflections of the sensory findings in the central nervous system in patients with neuropathic pain

  2022cites this paper
• Contemporary management of pain in cirrhosis: Toward precision therapy for pain

  2022cites this paper
• Migraine and peripheral pain models show differential alterations in neuronal complexity

  2022cites this paper
• Central sensitization in opioid use disorder: a novel application of the American College of Rheumatology Fibromyalgia Survey Criteria

  2022cites this paper
• Nociplastic pain concept, a mechanistic basis for pragmatic approach to fibromyalgia

  2022cites this paper
• Is primary dysmenorrhea affected by gray matter volumetric changes in the brain?

  2022cites this paper
• Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain

  2022cites this paper
• Structural imaging studies of patients with chronic pain: an anatomic likelihood estimate meta-analysis.

  2022cites this paper
• Imaging as a Pain Biomarker.

  2022cites this paper
• Efficacy of Fluoxetine, Riluzole and Amiloride in treating neuropathic pain associated with secondary progressive multiple sclerosis. Pre-specified analysis of the MS-SMART double-blind randomised placebo-controlled trial.

  2022cites this paper
• Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses

  2022cites this paper
• Increased gray matter following mindfulness-based stress reduction in breast cancer survivors with chronic neuropathic pain: preliminary evidence using voxel-based morphometry

  2022cites this paper
• Gray Matter Volume Abnormality in Chronic Pain Patients With Depressive Symptoms: A Systemic Review and Meta-Analysis of Voxel-Based Morphometry Studies

  2022cites this paper
• Identification of Deep Brain Stimulation Targets for Neuropathic Pain After Spinal Cord Injury Using Localized Increases in White Matter Fiber Cross-Section.

  2021cites this paper
• The self in context: brain systems linking mental and physical health

  2021cites this paper
• Nociplastic pain: towards an understanding of prevalent pain conditions.

  2021cites this paper
• Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies

  2021cites this paper
• Grey matter brain alterations in temporomandibular disorder tested in a population cohort and three clinical samples.

  2021cites this paper
• Gray Matter Volume Differences Between More Versus Less Resilient Adults with Chronic Musculoskeletal Pain: A Voxel-Based Morphology Study.

  2021cites this paper
• The default mode network in cognition: a topographical perspective

  2021cites this paper