Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor

Previous attempts at identifying the constitutive source(s) of granulocyte colony-stimulating factor (G-CSF) in human bone marrow have been unsuccessful despite the fact that normal bone marrow supports abundant myelopoiesis in vivo. We hypothesized that the intimate physical association between bone and hematopoietic cells facilitates interactions between osteoblasts and hematopoietic stem cells. Here we provide the first direct evidence that human osteoblasts participate in hematopoiesis by constitutively producing G-CSF and present the protein in a membrane-associated fashion to human hematopoietic progenitors. These results suggest a direct and central role for osteoblasts in normal myelopoiesis.

• Publication year

  1994

• Venue

  Journal of Experimental Medicine

• Publication date

  1994-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.179.5.1677PMID 7513014PMCID 2191506
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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