Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Neuron

• Publication date

  1989-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0896-6273(89)90033-0PMID 2560392
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• GABAergic neocortical neurons are resistant to NMDA receptor‐mediated injury

  1989cited by this paper
• Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons

  1988cited by this paper
• Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

  1988cited by this paper
• Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.

  1988cited by this paper
• Interactions between entorhinal axons and target hippocampal neurons: a role for glutamate in the development of hippocampal circuitry.

  1988cited by this paper
• Excitotoxity and the NMDA receptor

  1987cited by this paper
• Glutamate neurotoxicity in cortical cell culture

  1987cited by this paper
• Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices.

  1987cited by this paper
• Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortex.

  1987cited by this paper
• The neurotransmitter amino acid transport systems. A fresh outlook on an old problem.

  1987cited by this paper
• Hippocampal neuron loss in temporal lobe epilepsy: Correlation with early childhood convulsions

  1987cited by this paper
• Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

  1987cited by this paper
• Cellular mechanisms of epilepsy: a status report.

  1987cited by this paper
• Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy.

  1987cited by this paper
• Models of synchronized hippocampal bursts in the presence of inhibition. I. Single population events.

  1987cited by this paper
• Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist.

  1987cited by this paper
• An N-methyl-D-aspartate (NMDA) receptor antagonist reduces bicuculline-induced depolarization shifts in neocortical explant cultures.

  1986cited by this paper
• Synaptic functions in rat sympathetic neurons in microcultures. I. Secretion of norepinephrine and acetylcholine

  1986cited by this paper
• Primary culture of identified neurons from the visual cortex of postnatal rats

  1986cited by this paper
• Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists

  1986cited by this paper
• Epileptic brain damage: pathophysiology and neurochemical pathology.

  1986cited by this paper
• Excitotoxic mechanisms of epileptic brain damage.

  1986cited by this paper
• Epileptiform activity induced by changes in extracellular potassium in hippocampus.

  1985cited by this paper
• A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.

  1985cited by this paper
• Sustained potential shifts and paroxysmal discharges in hippocampal formation.

  1985cited by this paper
• The nature of the chick's magnesium-sensitive retinal spreading depression

  1984cited by this paper
• A bicuculline‐resistant inhibitory post‐synaptic potential in rat hippocampal pyramidal cells in vitro.

  1984cited by this paper
• Seizure-like spreading depression in immature rabbit hippocampus in vitro.

  1984cited by this paper
• Magnesium gates glutamate-activated channels in mouse central neurones

  1984cited by this paper
• Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

  1984cited by this paper
• The nature of the chick's magnesium-sensitive retinal spreading depression.

  1984cited by this paper
• Developmental and neurochemical specificity of neuronal deficits produced by electrical impulse blockade in dissociated spinal cord cultures.

  1983cited by this paper
• Rat hippocampal neurons in culture: responses to electrical and chemical stimuli.

  1983cited by this paper
• Mechanisms of neocortical epileptogenesis in vitro.

  1982cited by this paper
• Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors

  1982cited by this paper
• Anticonvulsant action of excitatory amino acid antagonists.

  1982cited by this paper
• 2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation.

  1981cited by this paper
• Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex.

  1981cited by this paper
• Giant synaptic potential hypothesis for epileptiform activity.

  1981cited by this paper
• Intrastriatal folic acid mimics the distant but not local brain damaging properties of kainic acid.

  1981cited by this paper
• Selective survival of neurons from chick embryo sensory ganglionic dissociates utilizing serum-free supplemented medium.

  1980cited by this paper
• Long-term culture of dissociated sympathetic neurons.

  1979cited by this paper
• Extracellular ionic variations during spreading depression.

  1978cited by this paper
• Rat hippocampal neurons in dispersed cell culture.

  1977cited by this paper
• Potassium activity in rabbit cortex.

  1974cited by this paper
• GLUTAMATE‐INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS: An Electron Microscopic Study

  1971cited by this paper
• Penicillin-induced interictal discharges from the cat hippocampus. II. Mechanisms underlying origin and restriction.

  1969cited by this paper
• CORTICAL CELLULAR PHENOMENA IN EXPERIMENTAL EPILEPSY: ICTAL MANIFESTATIONS.

  1964cited by this paper
• CORTICAL CELLULAR PHENOMENA IN EXPERIMENTAL EPILEPSY: INTERICTAL MANIFESTATIONS.

  1964cited by this paper
• Excitation and inhibition of single pyramidal cells during hippocampal seizure.

  1961cited by this paper
• Compounds in brain extracts causing spreading depression of cerebral cortical activity and contraction of crustacean muscle.

  1959cited by this paper
• COMPOUNDS IN BRAIN EXTRACTS CAUSING SPREADING DEPRESSION OF CEREBRAL CORTICAL ACTIVITY AND CONTRACTION OF CRUSTACEAN MUSCLE

  1959cited by this paper

• Modeling mTORopathy-related epilepsy in cultured murine hippocampal neurons using the multi-electrode array

  2024cites this paper
• Assessment of Sexual Dysfunction in Male Patients with Young-Onset Parkinson’s Disease: A Case-Control Study

  2024cites this paper
• Cannabinoid receptors involved in descending inhibition on spinal seizure-like activity in the phrenic output.

  2023cites this paper
• Can in vitro studies aid in the development and use of antiseizure therapies? A report of the ILAE/AES Joint Translational Task Force

  2023cites this paper
• Optical Spike Detection and Connectivity Analysis With a Far-Red Voltage-Sensitive Fluorophore Reveals Changes to Network Connectivity in Development and Disease

  2020cites this paper
• Altered Fast Synaptic Transmission in a Mouse Model of DNM1-Associated Developmental Epileptic Encephalopathy

  2020cites this paper
• In Vitro Models of Brain Disorders.

  2019cites this paper
• Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-&agr;2-glycoprotein in primary cultured cortical neurons

  2019cites this paper
• How do we use in vitro models to understand epileptiform and ictal activity? A report of the TASK1‐WG4 group of the ILAE/AES Joint Translational Task Force

  2018cites this paper
• The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries

  2018cites this paper
• Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels

  2017cites this paper
• Functional consequences of mutations in GRIN2A and GRIN2B associated with mental disorders

  2017cites this paper
• The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences

  2017cites this paper
• Effects of riluzole on spinal seizure-like activity in the brainstem-spinal cord preparation of newborn rat.

  2017cites this paper
• Pannexin-1 channels in epilepsy.

  2017cites this paper
• Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers.

  2017cites this paper
• Models of drug-induced epileptiform synchronization in vitro.

  2016cites this paper
• Metabotropic Glutamate Receptor

  2016cites this paper
• Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function

  2016cites this paper
• Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays

  2013cites this paper
• Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays

  2013cites this paper
• Ultra slow oscillations in cortical cultures

  2012cites this paper
• Epileptiform activity in the limbic system.

  2011cites this paper
• Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance.

  2011cites this paper
• Functional clustering in hippocampal cultures: relating network structure and dynamics

  2010cites this paper
• Functional clustering in hippocampal cultures

  2010cites this paper
• Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel

  2009cites this paper
• Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice.

  2009cites this paper
• Spontaneous Calcium Transients in Cultured Cortical Networks During Development

  2009cites this paper
• Understanding the Interplay of Structure and Dynamics in Neuronal Networks.

  2009cites this paper
• Reduced expression of the "fast" calcium transporter PMCA2a during homeostatic plasticity.

  2009cites this paper
• Synaptic plasticity and Hebbian cell assemblies

  2008cites this paper
• Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.

  2008cites this paper
• 17 – Homeostatic Plasticity and post-Traumatic Epileptogenesis

  2008cites this paper
• Role of spontaneous bursts in functional plasticity and spatiotemporal dynamics of dissociated cortical cultures

  2007cites this paper
• Endogenous mechanisms of neuroprotection

  2007cites this paper
• An in vitro model of stroke-induced epilepsy: elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke-induced epileptogenesis.

  2007cites this paper
• Hyperexcitability of Distal Dendrites in Hippocampal Pyramidal Cells after Chronic Partial Deafferentation

  2007cites this paper
• Kynurenate treatment of autaptic hippocampal microcultures affect localized voltage-dependent calcium diffusion in the dendrites.

  2006cites this paper
• Multi-site Stimulation Quiets Network-wide Spontaneous Bursts and Enhances Functional Plasticity in Cultured Cortical Networks

  2006cites this paper
• NMDA neuroprotection against a phosphatidylinositol‐3 kinase inhibitor, LY294002 by NR2B‐mediated suppression of glycogen synthase kinase‐3β‐induced apoptosis

  2006cites this paper
• Network stability through homeostatic scaling of excitatory and inhibitory synapses following inactivity in CA3 of rat organotypic hippocampal slice cultures.

  2006cites this paper
• Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.

  2006influential citation
• Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.

  2005cites this paper
• ControllingBurstinginCorticalCultureswithClosed-Loop Multi-ElectrodeStimulation

  2005influential citation
• Homeostatic synaptic plasticity can explain post-traumatic epileptogenesis in chronically isolated neocortex.

  2005cites this paper
• PROLONGED NMDA-MEDIATED SYNAPTIC RESPONSES , ALTERED IFENPRODIL SENSITIVITY , AND GENERATION OF EPILEPTIFORM-LIKE EVENTS IN THE MALFORMED HIPPOCAMPUS OF RATS EXPOSED TO METHYLAZOXYMETHANOL IN UTERO

  2005cites this paper
• Production of GABA by cultured hippocampal glial cells.

  2004cites this paper
• Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)

  2004cites this paper
• Weak synaptic activity induces ongoing signaling to the nucleus that is enhanced by BDNF and suppressed by low-levels of nicotine.

  2004cites this paper
• Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy.

  2004cites this paper
• The role of nuclear factors of activated T-cells (NFAT) in neuronal death.

  2004cites this paper
• Characterization of Two Novel N -Methyl- D -aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo Acid) and EAB-318 ( R - (cid:1) -Amino-5-chloro-1-(phosphonomethyl)-1 H -benzimidazole-2-propanoic Acid Hydrochloride)

  2004cites this paper
• Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients.

  2003cites this paper
• Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo

  2003cites this paper
• Auswirkungen neurologischer Erkrankungen auf Sexualität und Partnerschaft

  2003cites this paper
• Seizure-like activity leads to the release of BAD from 14-3-3 protein and cell death in hippocampal neurons in vitro

  2003cites this paper
• Mitogen and stress response kinase‐1 (MSK1) mediates excitotoxic induced death of hippocampal neurones

  2003cites this paper
• Chronic treatment with ionotropic glutamate receptor antagonist kynurenate affects GABAergic synaptic transmission in rat hippocampal cell cultures.

  2003cites this paper
• Physiological effects of sustained blockade of excitatory synaptic transmission on spontaneously active developing neuronal networks--an inquiry into the reciprocal linkage between intrinsic biorhythms and neuroplasticity in early ontogeny.

  2002cites this paper
• Spontaneous development of synchronous oscillatory activity during maturation of cortical networks in vitro.

  2002cites this paper
• Sodium channels and epilepsy electrophysiology.

  2002cites this paper
• Neuronal‐induced and glutamate‐dependent activation of glial glutamate transporter function

  2002cites this paper
• Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus.

  2002cites this paper
• Acetylcholine Becomes the Major Excitatory Neurotransmitter in the Hypothalamus In Vitro in the Absence of Glutamate Excitation

  2001cites this paper
• Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities.

  2001cites this paper
• Neuronal Protein Kinase Signaling Cascades and Excitotoxic Cell Death

  2001cites this paper
• cAMP-Dependent Protein Kinase Mediates Activity-Regulated Synaptic Targeting of NMDA Receptors

  2001cites this paper
• Glutamate Injury–Induced Epileptogenesis in Hippocampal Neurons: An In Vitro Model of Stroke-Induced “Epilepsy”

  2001cites this paper
• Potentiation by histamine of synaptically mediated excitotoxicity in cultured hippocampal neurones: a possible role for mast cells

  2001cites this paper
• Suppression of Neuronal Hyperexcitability and Associated Delayed Neuronal Death by Adenoviral Expression of GABACReceptors

  2001influential citation
• Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex.

  2001cites this paper
• Neuronal Activity and Brain-Derived Neurotrophic Factor Regulate the Density of Inhibitory Synapses in Organotypic Slice Cultures of Postnatal Hippocampus

  2000cites this paper
• Effects of extracellular human immunodeficiency virus type 1 vpr protein in primary rat cortical cell cultures.

  2000cites this paper
• Prolonged Inhibition of Glutamate Reuptake Down‐Regulates NMDA Receptor Functions in Cultured Cerebellar Granule Cells

  1999cites this paper
• Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappaB activation and apoptosis in rat striatum.

  1999cites this paper
• Brain-derived Neurotrophic Factor Induces Phosphorylation of Fibroblast Growth Factor Receptor Substrate 2*

  1999cites this paper
• Differential neurite growth on astrocyte substrates: interspecies facilitation in green fluorescent protein-transfected rat and human neurons.

  1999cites this paper
• Chronic Epilepsy in Developing Hippocampal Neurons: Electrophysiologic and Morphologic Features

  1999cites this paper
• L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells.

  1999cites this paper
• Astrocytes are required for the oscillatory activity in cultured hippocampal neurons

  1999influential citation
• Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.

  1999cites this paper
• Neurotoxicity mediated by aberrant patterns of synaptic activity between rat hippocampal neurons in culture.

  1998cites this paper
• Activity-dependent modulation of synaptic AMPA receptor accumulation.

  1998cites this paper
• Dopamine Neurons Make Glutamatergic Synapses In Vitro

  1998cites this paper
• Region-specific changes in [3H]dizocilpine binding in diazepam-withdrawn rats.

  1998cites this paper
• Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity.

  1998cites this paper
• Melatonin prevents the delayed death of hippocampal neurons induced by enhanced excitatory neurotransmission and the nitridergic pathway

  1998cites this paper
• Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.

  1997cites this paper
• Intrinsic NMDA-induced oscillations in motoneurons of an adult vertebrate spinal cord are masked by inhibition.

  1997cites this paper
• Dopamine inhibition: enhancement of GABA activity and potassium channel activation in hypothalamic and arcuate nucleus neurons.

  1997cites this paper
• Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons.

  1997cites this paper
• Presynaptically silent synapses: spontaneously active terminals without stimulus-evoked release demonstrated in cortical autapses.

  1997cites this paper
• Presynaptic action of the neurosteroid pregnenolone sulfate on inhibitory transmitter release in cultured hippocampal neurons.

  1997cites this paper
• Local synaptic release of glutamate from neurons in the rat hypothalamic arcuate nucleus.

  1997cites this paper
• Properties of cochlear nucleus neurons in primary culture.

  1997cites this paper
• Effects of neuronal proteoglycans on activity-dependent growth responses of fetal hippocampal neurons.

  1997cites this paper
• Dendritic spine density and LTP induction in cultured hippocampal slices.

  1997cites this paper
• Separating EEG Spike-Clusters in Epilepsy by a Growing and Splitting Net

  1996cites this paper
• Biotin deficiency facilitates kindling hyperexcitability in rats.

  1996cites this paper