Exploration of biguanido–oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Biometals

• Publication date

  2012-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s10534-012-9548-4PMID 22547055
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex.

  2012cited by this paper
• Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization and biological activities.

  2011cited by this paper
• Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases.

  2011cited by this paper
• Ternary oxovanadium(IV) complexes with amino acid-Schiff base and polypyridyl derivatives: synthesis, characterization, and protein tyrosine phosphatase 1B inhibition.

  2011cited by this paper
• Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases.

  2011cited by this paper
• Metal-based inhibitors of protein tyrosine phosphatases.

  2011cited by this paper
• Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives

  2011cited by this paper
• Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems.

  2010cited by this paper
• Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives.

  2010cited by this paper
• Inhibition protein tyrosine phosphatases by an oxovanadium glutamate complex, Na2[VO(Glu)2(CH3OH)](Glu = glutamate)

  2010cited by this paper
• Ternary oxovanadium(IV) complexes of ONO-donor Schiff base and polypyridyl derivatives as protein tyrosine phosphatase inhibitors: synthesis, characterization, and biological activities

  2009cited by this paper
• Vanadium treatment of type 2 diabetes: a view to the future.

  2009cited by this paper
• Inhibition of protein tyrosine phosphatase 1B and alkaline phosphatase by bis(maltolato)oxovanadium (IV).

  2008cited by this paper
• Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3alpha1.

  2008cited by this paper
• Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors.

  2007cited by this paper
• 5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.

  2007cited by this paper
• A two stage click-based library of protein tyrosine phosphatase inhibitors.

  2007cited by this paper
• Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.

  2007cited by this paper
• Isolation of a pentadentate ligand and stepwise synthesis, structures, and magnetic properties of a new family of homo- and heterotrinuclear complexes.

  2007cited by this paper
• PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.

  2007cited by this paper
• Ferromagnetic Coupling Promoted by ? 3 N :? 2 N Bridging System

  2006cited by this paper
• Structural Insights into the Design of Nonpeptidic Isothiazolidinone-containing Inhibitors of Protein-tyrosine Phosphatase 1B*

  2006cited by this paper
• A systematic study of ligand intermolecular interactions in crystals of copper(II) complexes of bidentate guanidino derivatives

  2006cited by this paper
• Ferromagnetic coupling promoted by kappa3N:kappa2N bridging system.

  2006cited by this paper
• Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.

  2006cited by this paper
• Genetic analysis of the kinome and phosphatome in cancer

  2005cited by this paper
• Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.

  2005cited by this paper
• Protein tyrosine phosphatase: enzymatic assays.

  2005cited by this paper
• Bis(biguanido-κ2N,N′)copper(II) dihydrate

  2005cited by this paper
• Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site.

  2005cited by this paper
• Protein tyrosine phosphatases and their inhibitors.

  2005cited by this paper
• A Nonspecific Phosphotyrosine Phosphatase Inhibitor, Bis(maltolato)oxovanadium(IV), Improves Glucose Tolerance and Prevents Diabetes in Zucker Diabetic Fatty Rats

  2005cited by this paper
• Two N,N-dimethylbiguanidium salts displaying double hydrogen bonds to the counter-ions.

  2004cited by this paper
• Bis[1,1-dimethylbiguanide(1-)-kappa2N2,N5]copper(II) monohydrate.

  2004cited by this paper
• ReviewProtein Tyrosine Phosphatases in the Human

  2004cited by this paper
• Protein tyrosine phosphatases in the human genome.

  2004cited by this paper
• The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds.

  2004cited by this paper
• A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage

  2004cited by this paper
• Bis[1,1‐di­methyl­biguanide(1–)‐κ2N2,N5]copper(II) monohydrate

  2004cited by this paper
• Cocrystal of the [MnIVC2H7N5)3]4+ ion and biguanidium: a double hydrogen-bond interaction with guanidinium-recognizing anions.

  2004cited by this paper
• Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes

  2003cited by this paper
• Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component.

  2003cited by this paper
• N-Phenethyl­biguanidium tetra­chloro­zincate(II)

  2003cited by this paper
• Biological and medicinal aspects of vanadium

  2003cited by this paper
• N,N‐Di­methyl­biguanidium nitrate

  2003cited by this paper
• Bis{N′‐[(E)‐amino­(imino)­methyl]­morpholinocarboximid­amido}copper(II)

  2003cited by this paper
• Trichloro(1,1-dimethylbiguanidium-kappa N3)zinc(II).

  2002cited by this paper
• Bis(1,1-di­methyl­biguanido)­nickel(II)

  2002cited by this paper
• Structure Determination of T Cell Protein-tyrosine Phosphatase*

  2002cited by this paper
• Modification of supramolecular motifs: some effects of incorporation of metal complexes into supramolecular arrays

  2002cited by this paper
• Bis(1,1‐di­methyl­biguanido)copper(II) octahydrate

  2002cited by this paper
• Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B).

  2002cited by this paper
• PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

  2002cited by this paper
• Trichloro(1,1-dimethylbiguanidium-κN3)zinc(II)

  2002cited by this paper
• Insulin signalling and the regulation of glucose and lipid metabolism

  2001cited by this paper
• Protein tyrosine phosphatases: prospects for therapeutics.

  2001cited by this paper
• Proton Controlled Supramolecular Assembly: A Comparative Structural Study of Bis(2-guanidinobenzimidazolo)nickel(II) with Bis(2-guanidinobenzimidazole)nickel(II) Nitrate and 2-guanidinobenzimidazole

  2001cited by this paper
• Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV).

  2001cited by this paper
• Speciation and NMR relaxation studies of VO(IV) complexes with several O-donor containing ligands: oxalate, malonate, maltolate and kojate

  2000cited by this paper
• Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

  2000cited by this paper
• Structure-based Design of a Low Molecular Weight, Nonphosphorus, Nonpeptide, and Highly Selective Inhibitor of Protein-tyrosine Phosphatase 1B*

  2000cited by this paper
• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
• Technetium(V) and rhenium(V) complexes of biguanide derivatives. Crystal structures

  1999cited by this paper
• Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats

  1999cited by this paper
• Vanadyl-biguanide complexes as potential synergistic insulin mimics.

  1999cited by this paper
• Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction

  1998cited by this paper
• Crystal Structure of the Catalytic Domain of Protein-tyrosine Phosphatase SHP-1*

  1998cited by this paper
• Insulin receptor-associated protein tyrosine phosphatase(s): Role in insulin action

  1998cited by this paper
• Kinetics and molecular modelling studies of the inhibition of protein tyrosine phosphatases by N,N-dimethylhydroxylamine complexes of vanadium(V)

  1998cited by this paper
• Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate*

  1997cited by this paper
• Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling*

  1996cited by this paper
• Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite of programs.

  1996cited by this paper
• Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

  1994cited by this paper
• Spectra and structure of tris-bidentate cobalt(III) complexes containing planar ligands

  1978cited by this paper
• Inorganic Electronic Spectroscopy

  1968cited by this paper
• Complex Compounds of Biguanides and Guanylureas with Metallic Elements.

  1961cited by this paper

• PTPN2: Advances and perspectives in cancer treatment potential and inhibitor research.

  2025cites this paper
• Structural and kinetic characterization of DUSP5 with a Di-phosphorylated tripeptide substrate from the ERK activation loop

  2024cites this paper
• Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances

  2024cites this paper
• Moroxydine Tautomers - A DFT Treatment

  2023cites this paper
• Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

  2022influential citation
• Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl2 and CHX-ZnCl2 Particles

  2021cites this paper
• In vitroexperiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes

  2019cites this paper
• Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV.

  2017cites this paper
• Inhibition of Src homology 2 domain containing protein tyrosine phosphatase as the possible mechanism of metformin-assisted amelioration of obesity induced insulin resistance in high fat diet fed C57BL/6J mice.

  2017cites this paper
• Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders

  2016cites this paper
• Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders

  2016cites this paper
• The Protein Tyrosine Kinase Inhibitor Tyrphostin 23 Strongly Accelerates Glycolytic Lactate Production in Cultured Primary Astrocytes

  2016cites this paper
• Antidiabetic, Chemical, and Physical Properties of Organic Vanadates as Presumed Transition-State Inhibitors for Phosphatases.

  2015cites this paper
• Vanadium–phosphatase complexes: Phosphatase inhibitors favor the trigonal bipyramidal transition state geometries

  2015cites this paper
• Synthesis of Metforminium(2+) Decavanadates – Crystal Structures and Solid‐State Characterization

  2014cites this paper
• Protein Tyrosine Phosphatase Inhibition by Metals and Metal Complexes

  2014cites this paper
• Effects of vanadium (III, IV, V)-chlorodipicolinate on glycolysis and antioxidant status in the liver of STZ-induced diabetic rats.

  2014cites this paper
• Assemblies of salen-type oxidovanadium(IV) complexes: substituent effects and in vitro protein tyrosine phosphatase inhibition.

  2014cites this paper
• A marriage of two “Methusalem” drugs for the treatment of psoriasis?

  2013cites this paper
• 3.13 – Vanadium Biochemistry

  2013cites this paper