Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling*

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Journal of Biological Chemistry

• Publication date

  1996-08-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.271.33.19810PMID 8702689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thiazolidine Derivatives Ameliorate High Glucose-induced Insulin Resistance via the Normalization of Protein-tyrosine Phosphatase Activities (*)

  1995cited by this paper
• Evidence against dephosphorylation of insulin-elicited phosphotyrosine proteins in vivo by the phosphatase PTP2C.

  1995cited by this paper
• Purification, identification and subcellular distribution of three predominant protein-tyrosine phosphatase enzymes in skeletal muscle tissue.

  1995cited by this paper
• Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

  1995cited by this paper
• Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.

  1995cited by this paper
• Insulin Receptor Signaling Is Augmented by Antisense Inhibition of the Protein Tyrosine Phosphatase LAR (*)

  1995cited by this paper
• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  1994cited by this paper
• Identification of protein-tyrosine phosphatases prevalent in adipocytes by molecular cloning.

  1994cited by this paper
• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  1994cited by this paper
• Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate‐1 via different phosphotyrosine motifs

  1994cited by this paper
• Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

  1994cited by this paper
• Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

  1994cited by this paper
• Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2.

  1994cited by this paper
• High glucose condition activates protein tyrosine phosphatases and deactivates insulin receptor function in insulin-sensitive rat 1 fibroblasts.

  1994cited by this paper
• Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.

  1994cited by this paper
• Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.

  1994cited by this paper
• Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.

  1994cited by this paper
• Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

  1994cited by this paper
• NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling.

  1994cited by this paper
• Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

  1994cited by this paper
• Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation.

  1993cited by this paper
• The function of GRB2 in linking the insulin receptor to Ras signaling pathways.

  1993cited by this paper
• Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I.

  1993cited by this paper
• A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.

  1993cited by this paper
• Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.

  1993cited by this paper
• Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation.

  1993cited by this paper
• Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid

  1993cited by this paper
• Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B.

  1993cited by this paper
• The dephosphorylation of insulin and epidermal growth factor receptors. Role of endosome-associated phosphotyrosine phosphatase(s).

  1992cited by this paper
• Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases.

  1992cited by this paper
• Decrease in beta-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase.

  1992cited by this paper
• Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system.

  1992cited by this paper
• The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence.

  1992cited by this paper
• Differential regulation of mRNAs encoding three protein-tyrosine phosphatases by insulin and activation of protein kinase C.

  1992cited by this paper
• Identification of skeletal muscle protein-tyrosine phosphatases by amplification of conserved cDNA sequences.

  1991cited by this paper
• Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

  1991cited by this paper
• Cloning and expression of a yeast protein tyrosine phosphatase.

  1991cited by this paper
• Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.

  1991cited by this paper
• Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.

  1991cited by this paper
• Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.

  1990cited by this paper
• The Insulin Receptor: A Multifunctional Protein

  1990cited by this paper
• Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes

  1990cited by this paper
• Cloning of a cDNA for a major human protein-tyrosine-phosphatase.

  1990cited by this paper
• A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

  1987cited by this paper
• After insulin binds.

  1987cited by this paper
• Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.

  1987cited by this paper
• Specificity of protein phosphotyrosine phosphatases. Comparison with mammalian alkaline phosphatase using polypeptide substrates.

  1985cited by this paper
• Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

  1985cited by this paper
• Organic extraction of Pi with isobutanol/toluene.

  1984cited by this paper
• Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

  1984cited by this paper
• Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase.

  1983cited by this paper
• Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor.

  1982cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Protein Arginine N‐Methyltransferase 4 Activation Contributes to Glucose‐Induced Skeletal Muscle Atrophy

  2025cites this paper
• Novel Yunaconitine Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors and Radical Scavenger: Design, Synthesis, in Vitro Cellular Evaluation, and Molecular Docking Study

  2025cites this paper
• Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis—A Narrative Review

  2025cites this paper
• Insights into PTP1B inhibitors as antidiabetic agents: Current research and future perspectives.

  2025cites this paper
• Protein tyrosine phosphatase 1B in metabolic and cardiovascular diseases: from mechanisms to therapeutics

  2024cites this paper
• Molecular crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of granulosa cell function

  2024cites this paper
• Design, synthesis and enzymatic inhibition evaluation of novel 4-hydroxy Pd-C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors.

  2024cites this paper
• Site-Specifically Modified Peptide Inhibitors of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase with Enhanced Stability and Improved In Vivo Long-Acting Activity.

  2024cites this paper
• Identification of 1,3,4-Thiadiazolyl-Containing Thiazolidine-2,4-dione Derivatives as Novel PTP1B Inhibitors with Antidiabetic Activity.

  2024cites this paper
• Mechanism of Inhibitory Effects of Phellodendrine on Diabetes Mellitus Using Molecular Docking Method

  2024cites this paper
• Ursonic acid from medicinal herbs inhibits PRRSV replication through activation of the innate immune response by targeting the phosphatase PTPN1

  2024cites this paper
• Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs

  2024cites this paper
• Biological Activities of Secondary Metabolites from the Edible-Medicinal Macrofungi

  2024cites this paper
• A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence

  2024cites this paper
• Pyrazole Scaffold: Potential PTP1B Inhibitors for Diabetes Treatment.

  2024cites this paper
• Discovery of Novel PTP1B Inhibitors with Once-Weekly Therapeutic Potential for Type 2 Diabetes: Design, Synthesis, and In Vitro and In Vivo Investigations of BimBH3 Peptide Analogues.

  2023cites this paper
• Isosteviol derivatives as protein tyrosine Phosphatase-1B inhibitors: Synthesis, biological evaluation and molecular docking.

  2023cites this paper
• Human relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice.

  2023cites this paper
• The effect of synthetic curcumin analogues on obesity, diabetes and cardiovascular Disease: a literature review.

  2023cites this paper
• New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation.

  2023cites this paper
• Identification of natural product inhibitors of PTP1B based on high-throughput virtual screening strategy: In silico, in vitro and in vivo studies.

  2023cites this paper
• Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: a Kinetic Approach

  2023cites this paper
• An Insight into the Development of Potential Antidiabetic Agents along with their Therapeutic Targets.

  2023cites this paper
• Human relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice

  2023cites this paper
• Mapping the Chemical Space of Active‐Site Targeted Covalent Ligands for Protein Tyrosine Phosphatases **

  2023cites this paper
• Terminal Phenoxy Group as a Privileged Moiety of the Drug Scaffold—A Short Review of Most Recent Studies 2013–2022

  2022cites this paper
• Hidden Agenda - The Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammation-Induced Muscle Wasting

  2022cites this paper
• Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid‐β oligomers

  2022cites this paper
• Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells

  2022cites this paper
• Synthesis, characterization, biomolecular interaction and in vitro glucose metabolism studies of dioxidovanadium(V) benzimidazole compounds

  2022cites this paper
• [Molecular mechanism of EGFR signaling evoked by environmental pollutant 1,2-naphthoquinone].

  2022cites this paper
• Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency.

  2021cites this paper
• All Good Things Must End: Termination of Receptor Tyrosine Kinase Signal

  2021cites this paper
• Screening and tissue distribution of protein tyrosine phosphatase 1B inhibitors in mice following oral administration of Garcinia mangostana L. ethanolic extract.

  2021cites this paper
• Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties.

  2021cites this paper
• Interaction of vanadium metal complexes with protein tyrosine phosphatase-1B enzyme along with identification of active site of enzyme by molecular modeling

  2021cites this paper
• Interactions of zinc- and redox-signaling pathways

  2021cites this paper
• Discovery of novel and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B): Virtual screening and molecular dynamic simulation

  2021cites this paper
• Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants

  2021cites this paper
• Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor

  2021cites this paper
• Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on cell proliferation, Apoptosis and Cell Signaling pathways.

  2021cites this paper
• Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, In Vitro and In Vivo Investigations of Jamunones.

  2021cites this paper
• Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides

  2020cites this paper
• Lanostane Triterpenoids with PTP1B Inhibitory and Glucose-Uptake Stimulatory Activities from Mushroom Fomitopsis pinicola Collected in North America.

  2020cites this paper
• Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes.

  2020cites this paper
• Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β

  2020cites this paper
• The bitter Asteraceae: An interesting approach to delay the metabolic syndrome progression

  2020cites this paper
• In vitro anti-diabetic assessment of guavanoic acid functionalized gold nanoparticles in regulating glucose transport using L6 rat skeletal muscle cells.

  2020cites this paper
• Effects of a natural PTP1B inhibitor from Rhodomela confervoides on the amelioration of fatty acid-induced insulin resistance in hepatocytes and hyperglycaemia in STZ-induced diabetic rats

  2020cites this paper
• Inhibitory effect of genistein and PTP1B on grasshopper Oedaleus asiaticus development

  2020cites this paper
• The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer’s Disease in APPSwe/PS1dE9 Mice

  2020cites this paper
• Recent advance on PTP1B inhibitors and their biomedical applications.

  2020cites this paper
• Antisense Oligonucleotides as Potential Therapeutics for Type 2 Diabetes

  2020cites this paper
• Uncarboxylated osteocalcin decreases insulin-stimulated glucose uptake without affecting insulin signaling and regulators of mitochondrial biogenesis in myotubes

  2020cites this paper
• Cloning and Functional Analysis of pqq Genes Phosphorus Solubilizing From Bacillus Mycoides Gnyt1

  2020cites this paper
• The antidiabetic drug lobeglitazone has the potential to inhibit PTP1B activity.

  2020cites this paper
• Anti-Diabetic Activity of 2,3,6-Tribromo-4,5-Dihydroxybenzyl Derivatives from Symphyocladia latiuscula through PTP1B Downregulation and α-Glucosidase Inhibition

  2019cites this paper
• Discovery of 2-ethoxy-4-(methoxymethyl)benzamide derivatives as potent and selective PTP1B inhibitors.

  2019cites this paper
• Unusual Prenylated Stilbene Derivatives with PTP1B Inhibitory Activity from Artocarpus styracifolius

  2019cites this paper
• Loss of growth hormone–mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity

  2019cites this paper
• Protein Tyrosine Phosphatase 1B inhibitors: a novel therapeutic strategy for the management of type 2 diabetes mellitus.

  2019cites this paper
• The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance

  2019cites this paper
• Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).

  2019cites this paper
• The pancreatic β-cell zinc response to chronic stimulation and extracellular zinc depletion

  2019cites this paper
• Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.

  2019cites this paper
• BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity.

  2019cites this paper
• Design, synthesis and biological evaluation of some tetrazole acetamide derivatives as novel non-carboxylic PTP1B inhibitors.

  2019cites this paper
• PTP1B up-regulates EGFR expression by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion in esophageal squamous cell carcinoma.

  2019cites this paper
• Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study.

  2018cites this paper
• IRS posttranslational modifications in regulating insulin signaling.

  2018cites this paper
• Early growth response‐1 negative feedback regulates skeletal muscle postprandial insulin sensitivity via activating Ptp 1b transcription

  2018cites this paper
• Rapid, precise and reproducible binding affinity prediction : applications in drug discovery

  2018cites this paper
• Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle

  2018cites this paper
• Protein tyrosine phosphatase 1B inhibitory activity of cone oils from Juniperus chinensis cv. Kaizuca and in silico theoretical explanation

  2018cites this paper
• Looking at Marine-Derived Bioactive Molecules as Upcoming Anti-Diabetic Agents: A Special Emphasis on PTP1B Inhibitors

  2018cites this paper
• Protein Tyrosine Phosphatase 1B Inhibition and Glucose Uptake Potentials of Mulberrofuran G, Albanol B, and Kuwanon G from Root Bark of Morus alba L. in Insulin-Resistant HepG2 Cells: An In Vitro and In Silico Study

  2018cites this paper
• A novel PTP1B inhibitor extracted from Ganoderma lucidum ameliorates insulin resistance by regulating IRS1-GLUT4 cascades in the insulin signaling pathway.

  2018cites this paper
• Molecular docking and DFT based QSAR study on Oleanolic acid derivatives as Protein-tyrosine phosphatase 1B inhibitors

  2018cites this paper
• Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts

  2018cites this paper
• Toward the identification of a reliable 3D-QSAR model for the protein tyrosine phosphatase 1B inhibitors

  2018cites this paper
• The development of protein tyrosine phosphatase1B inhibitors defined by binding sites in crystalline complexes.

  2018cites this paper
• Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches

  2018cites this paper
• Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model

  2017cites this paper
• Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

  2017influential citation
• α-Methyl artoflavanocoumarin from Juniperus chinensis exerts anti-diabetic effects by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant HepG2 cells

  2017cites this paper
• An association study revealed substantial effects of dominance, epistasis and substance dependence co‐morbidity on alcohol dependence symptom count

  2017cites this paper
• Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.

  2017cites this paper
• α-Methyl artoflavanocoumarin from Juniperus chinensis exerts anti-diabetic effects by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant HepG2 cells

  2017cites this paper
• PTP1B inhibitors from Selaginella tamariscina (Beauv.) Spring and their kinetic properties and molecular docking simulation.

  2017cites this paper
• Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cells

  2017cites this paper
• Protein Tyrosine Phosphatase 1B (PTPN1) Gene polymorphism (467T>C) and Metabolic Syndrome: A Pilot Study

  2017cites this paper
• Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.

  2017cites this paper
• Discovery of Bisindole as a Novel Scaffold for Protein Tyrosine Phosphatase 1B Inhibitors

  2017cites this paper
• Cichoric acid regulates the hepatic glucose homeostasis via AMPK pathway and activates the antioxidant response in high glucose-induced hepatocyte injury

  2017cites this paper
• Characterization of active compounds from Gracilaria lemaneiformis inhibiting the protein tyrosine phosphatase 1B activity.

  2017cites this paper
• Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.

  2017cites this paper
• The design strategy of selective PTP1B inhibitors over TCPTP.

  2016cites this paper
• Recent progress in studies on the health benefits of pyrroloquinoline quinone

  2016cites this paper
• Flavonoids: Prospective Strategy for the Management of Diabetes and Its Associated Complications

  2016cites this paper
• Pyrroloquinoline Quinone (PQQ)

  2016cites this paper