Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Development

• Publication date

  1993-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8330535
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

  2005cited by this paper
• DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.

  1992cited by this paper
• Distinct effects of ectopic expression of Wnt-1, activin B, and bFGF on gap junctional permeability in 32-cell Xenopus embryos.

  1992cited by this paper
• Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse.

  1992cited by this paper
• Gastrulation in the mouse: the role of the homeobox gene goosecoid.

  1992cited by this paper
• Expression of activins and TGFβ1 and β2 RNAs in early postimplantation mouse embryos and uterine decidua

  1992influential reference
• Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua.

  1992cited by this paper
• Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.

  1992cited by this paper
• Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.

  1992cited by this paper
• Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

  1992cited by this paper
• Nuclear translocation of fibroblast growth factor during Xenopus mesoderm induction.

  1991cited by this paper
• Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse.

  1991cited by this paper
• Differential localization of TGF-beta 2 in mouse preimplantation and early postimplantation development.

  1991cited by this paper
• Expression of the fibroblast growth factor-5 gene in the mouse embryo.

  1991cited by this paper
• Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.

  1991cited by this paper
• Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells

  1991cited by this paper
• Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A.

  1991cited by this paper
• Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone

  1991cited by this paper
• Follistatin binds to both activin and inhibin through the common subunit.

  1991cited by this paper
• Growth-factor-related proteins that are inducers in early amphibian development may mediate similar steps in amniote (bird) embryogenesis.

  1991cited by this paper
• Expression of inhibin/activin subunit messenger ribonucleic acids during rat embryogenesis.

  1991cited by this paper
• Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.

  1991cited by this paper
• Preparation of Monoclonal Antibodies to the Beta A Subunit of Ovarian Inhibin Using a Synthetic Peptide Immunogen

  1991cited by this paper
• Clonal analysis of epiblast fate during germ layer formation in the mouse embryo.

  1991influential reference
• Expression cloning of an activin receptor, a predicted transmembrane serine kinase.

  1991cited by this paper
• Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.

  1991cited by this paper
• FOLLISTATIN BINDS TO BOTH ACTIVIN AND INHIBIN THROUGH THE COMMON BETA-SUBUNIT

  1991cited by this paper
• mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation.

  1991cited by this paper
• Developmental expression of two murine fibroblast growth factor receptors, flg and bek.

  1991cited by this paper
• Histochemical localization of inhibin and activin alpha, beta A and beta B subunits in rat gonads.

  1991cited by this paper
• Cyclic changes in follistatin messenger ribonucleic acid and its protein in the rat ovary during the estrous cycle.

  1991cited by this paper
• Activin is a nerve cell survival molecule

  1990cited by this paper
• Expression of inhibin alpha-subunit gene during mouse gametogenesis.

  1990cited by this paper
• Expression pattern of the mouse T gene and its role in mesoderm formation

  1990cited by this paper
• Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

  1990cited by this paper
• Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction

  1990cited by this paper
• Cloning of the T gene required in mesoderm formation in the mouse

  1990cited by this paper
• Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor)

  1990cited by this paper
• Cell type-specific expression of transforming growth factor-beta 1 in the mouse uterus during the periimplantation period.

  1990cited by this paper
• Monoclonal and Polyclonal Antibodies Reactive with the 1-32 Amino Terminal Sequence of the Alpha Subunit of Human 32K Inhibin

  1990cited by this paper
• Fibroblast growth factor during mesoderm induction in the early chick embryo.

  1990cited by this paper
• Activin A stimulates meiotic maturation of the rat oocyte in vitro.

  1990influential reference
• Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick.

  1990cited by this paper
• The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF.

  1990cited by this paper
• Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.

  1990cited by this paper
• A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A.

  1990cited by this paper
• Activin/EDF as an inhibitor of neural differentiation.

  1990cited by this paper
• Measurement of developmental time by cells of early embryos.

  1990cited by this paper
• Postimplantation Mammalian Embryos: A Practical Approach

  1990cited by this paper
• Expression of inhibin α-subunit gene during mouse gametogenesis

  1990cited by this paper
• Activin-A, inhibin and transforming growth factor-beta modulate growth of two gonadal cell lines.

  1989cited by this paper
• A Laboratory manual

  1989cited by this paper
• Presence of basic fibroblast growth factor in the early Xenopus embryo

  1989cited by this paper
• An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo.

  1989influential reference
• An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

  1989influential reference
• Mesoderm induction and mesoderm-inducing factors in early amphibian development.

  1989cited by this paper
• Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

  1989cited by this paper
• Presence of basic fibroblast growth factor in the early embryo

  1989cited by this paper
• Cell allocation and lineage in the early mouse embryo.

  1989influential reference
• Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.

  1988cited by this paper
• The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer.

  1988cited by this paper
• Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos.

  1988cited by this paper
• Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions.

  1988cited by this paper
• Inhibins and activins.

  1988cited by this paper
• Evidence for a Cultivar and a Chronology from Patterned Wetlands in Central Veracruz, Mexico

  1988cited by this paper
• The development of animal cap cells in Xenopus: a measure of the start of animal cap competence to form mesoderm

  1987cited by this paper
• Gastrulation movements provide an early marker of mesoderm induction in Xenopus laevis

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence analysis of rat ovarian inhibins.

  1987cited by this paper
• Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.

  1987cited by this paper
• Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

  1987cited by this paper
• In vitro RNA synthesis with SP6 RNA polymerase.

  1987cited by this paper
• An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

  1987cited by this paper
• Experimental approaches to mammalian embryonic development: Potency, lineage, and allocation in preimplantation mouse embryos

  1987cited by this paper
• Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid

  1986cited by this paper
• Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin

  1986cited by this paper
• Manipulating the mouse embryo: A laboratory manual

  1986cited by this paper
• Inhibin A-subunit cDNAs from porcine ovary and human placenta.

  1986cited by this paper
• Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-β

  1985cited by this paper
• Activation of muscle-specific actin genes in Xenopus development by an induction between animal and vegetal cells of a blastula.

  1985cited by this paper
• The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium.

  1985influential reference
• Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.

  1984cited by this paper
• "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

  1984cited by this paper
• A comprehensive set of sequence analysis programs for the VAX

  1984cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983influential reference
• Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed

  1983cited by this paper
• A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.

  1982cited by this paper
• Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm

  1981cited by this paper
• Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

  1981influential reference
• Establishment in culture of pluripotential cells from mouse embryos

  1981influential reference
• Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP.

  1980cited by this paper
• Gap junctional communication in the preimplantation mouse embryo.

  1979cited by this paper
• The induction of differentiation in teratocarcinoma stem cells by retinoic acid.

  1978cited by this paper
• The formation of the mesoderm in urodelean amphibians

  1969cited by this paper
• Gonadal and extragonadal expression of inhibin a , 13 A , and BB subunits in various tissues predicts diverse functions

  year unknowncited by this paper

• Maternal/zygotic knockout and droplet digital polymerase chain reaction analysis question the role of activin A in preimplantation mouse embryo development

  2025cites this paper
• Role of p53 family members during development of striated muscle, with focus on p63

  2025cites this paper
• Zygotic activin A is dispensable for the mouse preimplantation embryo development and for the derivation and pluripotency of embryonic stem cells

  2024cites this paper
• Differential impact of TGFβ/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells

  2022cites this paper
• Evaluation of members of the TGFbeta superfamily as candidates for the oocyte factors that control mouse cumulus expansion and steroidogenesis.

  2019cites this paper
• Recombinant human activin A promotes development of bovine somatic cell nuclear transfer embryos matured in vitro

  2018cites this paper
• Isolation, Culture, and Functional Characterization of Human Embryonic Stem Cells: Current Trends and Challenges

  2018cites this paper
• Signaling pathways in mammalian preimplantation development: Linking cellular phenotypes to lineage decisions

  2017cites this paper
• Establishment of the Vertebrate Germ Layers.

  2017cites this paper
• Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

  2015cites this paper
• Change in the Gastro-Intestinal Tract by Overexpressed Activin Beta A

  2015cites this paper
• Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

  2015cites this paper
• Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems

  2015cites this paper
• Activin/Nodal signalling in stem cells

  2015cites this paper
• A Novel Nodal Enhancer Dependent on Pluripotency Factors and Smad2/3 Signaling Conditions a Regulatory Switch During Epiblast Maturation

  2014cites this paper
• Activin/Nodal signalling before implantation: setting the stage for embryo patterning

  2014cites this paper
• cDNA sequence analysis, recombinant expression of the inhibin α-subunit of the yak (Bos grunniens)

  2013cites this paper
• Changes in the reproductive endocrine function in rat following intraovary microinjection of inhba overexpression lentivirus vectors

  2013cites this paper
• (Matrix Metalloproteinase-2) Production in Activin A Stimulates Type IV Collagenase

  2013cites this paper
• Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo.

  2011cites this paper
• The role of activins and their antagonists in human melanoma cell lines

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• TAp63 Is Important for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

  2011cites this paper
• Coordination of Hox identity between germlayers along the anterior-to-posterior axisof the vertebrate embryo

  2010cites this paper
• Intracellular cathepsin B activity is inversely correlated with the quality and developmental competence of bovine preimplantation embryos

  2010cites this paper
• Transforming growth factor beta family expression at the bovine feto-maternal interface

  2010cites this paper
• Cathepsin B activity is related to the quality of bovine cumulus oocyte complexes and its inhibition can improve their developmental competence

  2010cites this paper
• Regulation of inhibin/activin expression in rat early antral follicles.

  2009cites this paper
• Kinetics of gene expression during exposure of mouse stem cells to activin A.

  2009cites this paper
• Oocyte-Secreted Factor Activation of SMAD 2/3 Signaling Enables Initiation of Mouse Cumulus Cell Expansion1

  2007cites this paper
• TGF-beta superfamily expression and actions in the endometrium and placenta.

  2006cites this paper
• CHAPTER 7 – Preimplantation Embryogenesis

  2006cites this paper
• TGF-β superfamily expression and actions in the endometrium and placenta

  2006cites this paper
• Regulation of cumulus expansion: role of oocyte-secreted factors and transforming growth factor β superfamily signalling

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• GDF3 at the Crossroads of TGF-beta Signaling

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• Autoimmune Targeted Disruption of the Pituitary-Ovarian Axis Causes Premature Ovarian Failure1

  2006cites this paper
• Complex expression patterns support potential roles for maternally derived activins in the establishment of pregnancy in mouse.

  2006cites this paper
• Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells

  2005cites this paper
• TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.

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• Expression of regulatory genes for pancreas development during murine embryonic stem cell differentiation.

  2005cites this paper
• GATA4, 5 and 6 mediate TGFβ maintenance of endodermal gene expression in Xenopus embryos

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• Microarray Analysis of LIF/Stat3 Transcriptional Targets in Embryonic Stem Cells

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• Cloning of Smad2, Smad3, Smad4, and Smad7 from the goldfish pituitary and evidence for their involvement in activin regulation of goldfish FSHbeta promoter activity.

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• TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

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• Artificial Organs and Stem Cell Biology

  2004cites this paper
• Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.

  2003cites this paper
• Immunohistochemical localization of inhibin/activin alpha, betaA and betaB subunits and follistatin in bovine oocytes during in vitro maturation and fertilization.

  2003influential citation
• Dynamics and Localization of Activin A Expression in Rat Gastric Ulcers

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• Development of the conditionally immortalized testicular Sertoli cell line TTE3 expressing Sertoli cell specific genes from mice transgenic for temperature sensitive simian virus 40 large T antigen gene.

  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
• Cloning and characterization of goldfish activin betaA subunit.

  1999cites this paper
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  1999cites this paper
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  1999cites this paper
• Cloning and characterization of goldfish activin βA subunit

  1999cites this paper
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  1999cites this paper
• Zonal regulation of gene expression during liver regeneration of urokinase transgenic mice

  1999cites this paper
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  1999cites this paper
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  1999cites this paper
• The Spemann organizer‐expressed zinc finger gene Xegr‐1 responds to the MAP kinase/Ets‐SRF signal transduction pathway

  1998cites this paper
• Developmental complexity of early mammalian pluripotent cell populations in vivo and in vitro.

  1998cites this paper
• Activin regulates betaA-subunit and activin receptor messenger ribonucleic acid and cellular proliferation in activin-responsive testicular tumor cells.

  1998cites this paper
• Mechanism and Function of Signaling by the TGFβ Superfamily

  1998cites this paper
• Identification of an Inhibin Receptor in Gonadal Tumors from Inhibin α-Subunit Knockout Mice*

  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998influential citation
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  1998influential citation
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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