The costimulation-regulated duration of PKB activation controls T cell longevity

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature Immunology

• Publication date

  2004-01-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni1030PMID 14730361
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

  2003cited by this paper
• CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.

  2003cited by this paper
• Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo

  2003cited by this paper
• Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

  2003cited by this paper
• Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma

  2003cited by this paper
• Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

  2003cited by this paper
• Cell cycle and death control: long live Forkheads.

  2002cited by this paper
• The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-21

  2002cited by this paper
• The CD28 signaling pathway regulates glucose metabolism.

  2002cited by this paper
• Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

  2002cited by this paper
• Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

  2002cited by this paper
• IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT1

  2002cited by this paper
• A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses.

  2002cited by this paper
• 4–1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity

  2002cited by this paper
• CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

  2002cited by this paper
• FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal

  2002cited by this paper
• Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

  2001cited by this paper
• OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.

  2001cited by this paper
• Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

  2001cited by this paper
• Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

  2001cited by this paper
• Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation1

  2001cited by this paper
• Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology*

  2001cited by this paper
• Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential.

  2000cited by this paper
• Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein*

  2000cited by this paper
• Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

  2000cited by this paper
• The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion1

  2000cited by this paper
• Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

  2000cited by this paper
• Control of homeostasis of CD8+ memory T cells by opposing cytokines.

  2000cited by this paper
• Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

  2000cited by this paper
• Cellular survival: a play in three Akts.

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.

  1999cited by this paper
• Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway*

  1998cited by this paper
• Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

  1998cited by this paper
• Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

  1998cited by this paper
• The duration of antigenic stimulation determines the fate of naive and effector T cells.

  1998cited by this paper
• Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses.

  1998cited by this paper
• Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

  1997cited by this paper
• Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

  1997cited by this paper
• Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

  1997cited by this paper
• Interleukin 3-dependent survival by the Akt protein kinase.

  1997cited by this paper
• Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.

  1997cited by this paper
• Expression and function of OX40 ligand on human dendritic cells.

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

  1995cited by this paper
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  1995cited by this paper
• Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.

  1987cited by this paper

• OX40 signaling in cancer immunotherapy: mechanisms of action, translational applications, and therapeutic perspectives.

  2026cites this paper
• Fatty acid β-oxidation enhances immune regulatory function of double-negative T cells through pSTAT4–OX40 signaling pathway

  2025cites this paper
• Ultrasound-Energized OX40L-Expressing Biohybrid for Multidimensional Mobilization of Sustained T Cell-Mediated Antitumor Immunity and Potent Sono-Immunotherapy.

  2025cites this paper
• The expression of OX40 in CD4+ T cells and its association with hepatic fibrosis injury.

  2025cites this paper
• Molecular mechanism of co-stimulatory domains in promoting CAR-T cell anti-tumor efficacy.

  2024cites this paper
• Blockade of OX40/OX40L signaling using anti‐OX40L alleviates murine lupus nephritis

  2024cites this paper
• The molecular crosstalk of the hippo cascade in breast cancer: A potential central susceptibility.

  2024cites this paper
• CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial

  2024cites this paper
• OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy.

  2023cites this paper
• Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection.

  2023cites this paper
• A Systems and Computational Biology Perspective on Advancing CAR Therapy.

  2023cites this paper
• Challenges and opportunities in the development of combination immunotherapy with OX40 agonists

  2023cites this paper
• Contribution of survivin to the immune system, allergies and autoimmune diseases.

  2023cites this paper
• Checkpoint: Inspecting the Barriers in Glioblastoma Immunotherapies.

  2022cites this paper
• NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance

  2022cites this paper
• Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8+ T cells

  2022cites this paper
• In or out of control: Modulating regulatory T cell homeostasis and function with immune checkpoint pathways

  2022cites this paper
• Tipping the scales: Immunotherapeutic strategies that disrupt immunosuppression and promote immune activation

  2022cites this paper
• Clinical Significance of OX40 and OX40 Ligand in the Peripheral Blood of Patients with Myasthenia Gravis

  2022cites this paper
• Strategy construction to minimize the limitation of respiratory viral vaccine development

  2022cites this paper
• Boosting Antitumor Response by Costimulatory Strategies Driven to 4-1BB and OX40 T-cell Receptors

  2021cites this paper
• Approaches of the Innate Immune System to Ameliorate Adaptive Immunotherapy for B-Cell Non-Hodgkin Lymphoma in Their Microenvironment

  2021cites this paper
• Hsa_circ_0000652 Aggravates Inflammation by Activation of Macrophages and Enhancement of OX40/OX40L Interaction in Ankylosing Spondylitis

  2021cites this paper
• Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics

  2021cites this paper
• The OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases

  2021cites this paper
• A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients with Locally Advanced or Metastatic Cancers

  2021cites this paper
• Cancer Immunotherapy

  2021cites this paper
• The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

  2020cites this paper
• ICOS Ligation Recruits the p50alpha PI3K Regulatory Subunit to the Immunological Synapse

  2020cites this paper
• Co-Stimulatory Receptors in Cancers and Their Implications for Cancer Immunotherapy

  2020cites this paper
• Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8+ T Cell Development

  2020cites this paper
• Lymphocyte mass cytometry identifies a CD3-CD4+ cell subset with a potential role in psoriasis.

  2019cites this paper
• A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors

  2019cites this paper
• Therapeutic strategies for the costimulatory molecule OX40 in T-cell-mediated immunity

  2019cites this paper
• The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond.

  2019cites this paper
• Signal Transduction Via Co-stimulatory and Co-inhibitory Receptors.

  2019cites this paper
• OX40L gene polymorphism and breast cancer in Iranian population.

  2018cites this paper
• Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

  2018cites this paper
• The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells

  2018cites this paper
• Characterisation of chicken OX40 and OX40L

  2018cites this paper
• Characterisation of mice deficient for the pro-survival BCL-2 family member A1/BFL-1

  2018cites this paper
• Checkpoint Blockade Therapy

  2018cites this paper
• Fundamental Mechanisms of Immune Checkpoint Blockade Therapy.

  2018cites this paper
• Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking

  2018cites this paper
• OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection

  2017cites this paper
• The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection

  2017cites this paper
• IL-21 is required for CD4 memory formation in response to viral infection.

  2017cites this paper
• Investigating the Role of Lipopolysaccharide and Polyinosinic:Polycytidylic Acid in Boosting CD4 T cell Responses

  2017cites this paper
• This information is current as Akt Signaling Pathways in T Cells Mitogen-Activated Protein Kinase Kinase and Negative Regulation by the The Bax N Terminus Is Required for

  2017cites this paper
• PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells

  2017cites this paper
• OX40: Structure and function - What questions remain?

  2017cites this paper
• The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection

  2017cites this paper
• The Ox 40 / Ox 40 Ligand Pathway Promotes Pathogenic Th Cell Responses , Plasmablast Accumulation , and Lupus Nephritis in NZB / W F 1 Mice

  2017cites this paper
• Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes

  2017cites this paper
• ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells

  2017cites this paper
• The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice

  2017cites this paper
• Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling

  2017cites this paper
• Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

  2017cites this paper
• Dying to protect: cell death and the control of T‐cell homeostasis

  2017cites this paper
• The Histamine H3 Receptor: Structure, Pharmacology, and Function

  2016cites this paper
• Parallel Costimulation of Effector and Regulatory T Cells by OX40, GITR, TNFRSF25, CD27, and CD137: Implications for Cancer Immunotherapy

  2016cites this paper
• Investigating the in vivo requirements for the generation and survival of CD4⁺ memory T cells

  2016cites this paper
• Rôles de deux corécepteurs impliqués dans le maintien des cellules T mémoires CD8+ et la maturation des cellules dendritiques

  2016cites this paper
• Thérapie ciblée anti-OX40 Ligand dans des modèles murins de Sclérodermie systémique

  2015cites this paper
• OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans

  2015cites this paper
• articleFoxP 3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development

  2015cites this paper
• Pulmonary dendritic cells and CD8 T cells facilitate protection following influenza A virus vaccination and infection

  2014cites this paper
• CD28 costimulation in T cells : requirements, outcomes and regulation

  2014cites this paper
• Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions.

  2014cites this paper
• Costimulatory TNFR family members in control of viral infection: outstanding questions.

  2014cites this paper
• Effects of OX40-OX40 ligand interaction on the levels of ROS and Cyclophilin A in C57BL/6J mice atherogenesis.

  2014cites this paper
• OX40 and IL‐7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells

  2014cites this paper
• Gene Expression in the Gitr Locus Is Regulated by NF-κB and Foxp3 through an Enhancer

  2014cites this paper
• Various ways to improve whole cancer cell vaccines

  2014cites this paper
• Regulation of A1 by OX40 Contributes to CD8+ T Cell Survival and Anti-Tumor Activity

  2013cites this paper
• the Regulation of Lymphocyte Homeostasis Signaling to Distinct Survival Pathways and B Couples Protein Kinase B/Akt κ NF-

  2013cites this paper
• Regulatory T Cells to Alloantigen T Cells and + of Effector/Memory CD4 A Diametric Role for OX40 in the Response

  2013influential citation
• A Diametric Role for OX40 in the Response of Effector/Memory CD4+ T Cells and Regulatory T Cells to Alloantigen

  2013influential citation
• Regulatory CD4+CD25+ T Lymphocytes Progression in Naive CD4+ T Cells by Uncoupling of IL-2 Signaling from Cell Cycle

  2013cites this paper
• SurvivalT Cell Expansion and B1 by OX40 Contributes to κ Activation of NF

  2013cites this paper
• OX40L/Jagged1 Cosignaling by GM-CSF–Induced Bone Marrow-Derived Dendritic Cells Is Required for the Expansion of Functional Regulatory T Cells

  2013cites this paper
• Can Be Inhibited by Natural Adjuvant Activity Leads to Activated T Cell Death and β Unrestrained Glycogen Synthase Kinase-3

  2013cites this paper
• The contextual role of TNFR family members in CD8+ T‐cell control of viral infections

  2013cites this paper
• Combination of virotherapy and T-cell therapy: arming oncolytic virus with T-cell engagers.

  2013cites this paper
• T-cell costimulatory blockade in organ transplantation.

  2013cites this paper
• This information is current as Tolerance to an Endogenous Tumor Antigen Overcome Established CD8+ T Cell GM-CSF Whole-Cell Vaccination to OX40 Costimulation Synergizes with

  2013cites this paper
• Cell signalling and feline immunodeficiency virus growth and latency

  2013cites this paper
• promotes survival of chronic lymphocytic leukemia B-cells Sustained signaling through the B-cell receptor induces Mcl-1 and

  2013cites this paper
• Responsesin Modulating Effector CD8 T Cell Functional Dichotomy between OX40 and

  2013cites this paper
• Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

  2013cites this paper
• Mechanisms of allergic diseases

  2013cites this paper
• New Insights on OX40 in the Control of T Cell Immunity and Immune Tolerance In Vivo

  2012cites this paper
• OX40 Facilitates Control of a Persistent Virus Infection

  2012cites this paper
• This information is current as the Development of T Cell Memory Death Extralong Isoform : Implications for Upregulates Bcl-2 Interacting Mediator of Degrades whereas Glycoprotein 120 α SDF-1

  2012cites this paper
• This information is current as Autoimmunity or Lymphoma Helper Function but Does Not Lead to Pten Loss in CD 4 T Cells Enhances Their

  2012cites this paper
• expansion and memory formation following vaccinia viral infection A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal

  2012cites this paper
• of Memory CD8 T Cells Extent of Stimulation Controls the Formation

  2012cites this paper
• SDF-1α Degrades whereas Glycoprotein 120 Upregulates Bcl-2 Interacting Mediator of Death Extralong Isoform: Implications for the Development of T Cell Memory

  2012cites this paper
• Investigation of the activation of tumour-specific immune responses by gene therapy strategies using a model tumour antigen

  2012cites this paper
• The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

  2012cites this paper