Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Structure

• Publication date

  2000-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0969-2126(00)00533-5PMID 11188689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The insertion of two amino acids into a transcriptional inducer converts it into a galactokinase.

  2000cited by this paper
• Structure of the 30S ribosomal subunit

  2000cited by this paper
• Organization of threonine biosynthesis genes from the obligate methylotroph Methylobacillus flagellatus.

  1999cited by this paper
• Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step.

  1999cited by this paper
• Overexpression, purification, and characterization of the thermostable mevalonate kinase from Methanococcus jannaschii.

  1999cited by this paper
• SCOP: a Structural Classification of Proteins database

  1999cited by this paper
• Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair.

  1999cited by this paper
• The design and implementation of SnB version 2.0

  1999cited by this paper
• The Saccharomyces cerevisiae Mevalonate Diphosphate Decarboxylase (Erg19p) Forms Homodimers In Vivo, and a Single Substitution in a Structurally Conserved Region Impairs Dimerization

  1999cited by this paper
• ThrH, a homoserine kinase isozyme with in vivo phosphoserine phosphatase activity in Pseudomonas aeruginosa.

  1999cited by this paper
• How do kinases transfer phosphoryl groups?

  1998cited by this paper
• A New Class of Phosphotransferases Phosphorylated on an Aspartate Residue in an Amino-terminal DXDX(T/V) Motif*

  1998cited by this paper
• Ribonuclease P protein structure: evolutionary origins in the translational apparatus.

  1998cited by this paper
• SCOP: a structural classification of proteins database

  1998cited by this paper
• Databases in protein crystallography.

  1998cited by this paper
• Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP

  1998cited by this paper
• Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis.

  1998cited by this paper
• The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases.

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• CATH--a hierarchic classification of protein domain structures.

  1997cited by this paper
• An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

  1997cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997cited by this paper
• Substrate specificity and identification of functional groups of homoserine kinase from Escherichia coli.

  1996cited by this paper
• Snapshot of an enzyme reaction intermediate in the structure of the ATP–Mg2+–oxalate ternary complex of Escherichia coli PEP carboxykinase

  1996cited by this paper
• The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange.

  1996cited by this paper
• Dali: a network tool for protein structure comparison.

  1995cited by this paper
• SCOP: a structural classification of proteins database for the investigation of sequences and structures.

  1995cited by this paper
• Mechanisms of phosphoryl and acyl transfer

  1995cited by this paper
• Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

  1995cited by this paper
• A ribosomal protein module in EF-G and DNA gyrase

  1995cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.

  1994cited by this paper
• Structural mechanisms for domain movements in proteins.

  1994cited by this paper
• The glycine-rich sequence of protein kinases: a multifunctional element.

  1994cited by this paper
• Domain movements in protein kinases.

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Convergent evolution of similar enzymatic function on different protein folds: The hexokinase, ribokinase, and galactokinase families of sugar kinases

  1993cited by this paper
• The structure of ribosomal protein S5 reveals sites of interaction with 16S rRNA

  1992cited by this paper
• An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.

  1992cited by this paper
• Isolation, organization and expression of the Pseudomonas aeruginosa threonine genes

  1992cited by this paper
• Binding of nucleotides by proteins

  1992cited by this paper
• Crystal structure of an N-terminal fragment of the DNA gyrase B protein

  1991cited by this paper
• Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase

  1991cited by this paper
• X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.

  1991cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• The P-loop--a common motif in ATP- and GTP-binding proteins.

  1990cited by this paper
• Homoserine kinase of Escherichia coli: kinetic mechanism and inhibition by L-aspartate semialdehyde.

  1984cited by this paper
• Conformation of nucleosides: circular dichroism study on the syn-anti conformational equilibrium of 2-substituted benzimidazole nucleosides.

  1979cited by this paper
• A 1H NMR Study of the Syn-Anti Dynamic Equilibrium in Adenine Nucleosides and Nucleotides with the Aid of Some Synthetic Model Analogues with Fixed Conformations

  1979cited by this paper
• Homoserine kinase from Escherichia coli K12.

  1976cited by this paper
• Conformation of nucleosides. Dipole moments of pyrimidine nucleosides.

  1974cited by this paper
• Homoserine Kinase from Escherichia coli K-12: Properties, Inhibition by l-Threonine, and Regulation of Biosynthesis

  1974cited by this paper
• Disorders of galactose metabolism

  1969cited by this paper
• Genetic and biochemical studies of genes controlling the synthesis of threonine and methionine in Saccharomyces.

  1966cited by this paper
• The structure of haemoglobin VIII. A three-dimensional Fourier synthesis at 5.5 Å resolution: determination of the phase angles

  1961cited by this paper
• Regulation of threonine biosynthesis in Escherichia coli.

  1958cited by this paper

• Carbohydrate kinase inhibition: a promising strategy in cancer treatment.

  2025cites this paper
• Engineering Corynebacterium glutamicum for efficient l-homoserine production.

  2025cites this paper
• Moonlighting activity of threonine synthase in cyanobacterial cell death

  2025cites this paper
• A global survey of taxa-metabolic associations across mouse microbiome communities.

  2025cites this paper
• Engineering homoserine kinase for competitive inhibition release to enhance l-threonine production in Corynebacterium glutamicum.

  2025cites this paper
• High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design

  2024cites this paper
• Expanded Archaeal Genomes Shed New Light on the Evolution of Isoprenoid Biosynthesis

  2024cites this paper
• The chemistry of Formycin biosynthesis

  2024cites this paper
• Genome-wide identification and gene expression analysis of GHMP kinase gene family in banana cv. Rasthali

  2023cites this paper
• Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase

  2023cites this paper
• A single site mutation can induce functional promiscuity in homoserine kinase.

  2023cites this paper
• Identification of potent inhibitors for Leishmania donovani homoserine kinase: an integrated in silico and kinetic study

  2023influential citation
• Inoculation with Lentilactobacillus buchneri alone or in combination with Lentilactobacillus hilgardii modifies gene expression, fermentation profile, and starch digestibility in high-moisture corn

  2023cites this paper
• Expression, Purification, and Preliminary X-ray Crystal Diffraction Analysis of the Saccharomyces cerevisiae Phosphomevalonate Kinase

  2023cites this paper
• Improvement of lycopene biosynthesis in waaC and waaF mutants of Escherichia coli by integrant expression of crtEBI gene and deletion of aceE and gdhA

  2022cites this paper
• How to Recruit a Promiscuous Enzyme to Serve a New Function.

  2022cites this paper
• Exploring the molecular interaction of pheniramine with Enterococcus faecalis homoserine kinase: In‐silico studies

  2022cites this paper
• Development of Auxotrophic Agrobacterium tumefaciens AGL1 by Tn5 Transposon for Rice (Oryza sativa L.) Transformation

  2021cites this paper
• CRISPR-Editing of Sweet Basil (Ocimum basilicum L.) Homoserine Kinase Gene for Improved Downy Mildew Disease Resistance

  2021cites this paper
• Recent Insights Into Mechanism and Structure of MEP Pathway Enzymes and Implications for Inhibition Strategies

  2020cites this paper
• Genome-Wide Identification and Analysis of GHMP Kinase Gene Superfamily in Bread Wheat (Triticum aestivum L.)

  2020influential citation
• Genome-Wide Identification and Analysis of GHMP Kinase Gene Superfamily in Bread Wheat (Triticum aestivum L.)

  2020cites this paper
• Molecular modeling and simulation study of homoserine kinase as an effective leishmanial drug target

  2020influential citation
• Uncovering the chemistry of C–C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex

  2020cites this paper
• Structure of the ForT/PRPP complex uncovers the mechanism of C-C bond formation in C-nucleotide antibiotic biosynthesis

  2020cites this paper
• Orthosteric and allosteric modulation of human kinases: A mechanistic view.

  2020cites this paper
• The phosphorylation mechanism of mevalonate diphosphate decarboxylase: a QM/MM study.

  2019cites this paper
• Catalytic mechanism of mevalonate kinase revisited, a QM/MM study.

  2019cites this paper
• Discovery of novel inhibitors of human galactokinase by virtual screening

  2019cites this paper
• Purification, kinetic characterization, and site-directed mutagenesis of Methanothermobacter thermautotrophicus RFAP Synthase Produced in Escherichia coli

  2019cites this paper
• Vitamin B12: From Deficiency to Biotechnological Solution

  2019cites this paper
• Transcriptome profiling of peppermint (Mentha piperita) with improved antioxidant properties in response to salicylic acid elicitation

  2018cites this paper
• Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) of Corynebacterium glutamicum Enhances l-Threonine Biosynthesis

  2018cites this paper
• Insight into the mechanism of galactokinase: Role of a critical glutamate residue and helix/coil transitions.

  2017cites this paper
• Molecular cloning, expression and immunolocalization analysis of diphosphomevalonate decarboxylase involved in terpenoid biosynthesis from Euphorbia helioscopia L.

  2017cites this paper
• Reconstruction of amino acid biosynthetic pathways increases the productivity of 2-keto-l-gulonic acid in Ketogulonicigenium vulgare-Bacillus endophyticus consortium via genes screening

  2017cites this paper
• Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation

  2017cites this paper
• Environmental Phosphorus Recovery Based on Molecular Bioscavengers

  2016cites this paper
• Biochemical Sulfuryl Group Transfer From 3-Phosphoadenosine 5-Phosphosulfate (PAPS) Versus Phosphoryl Transfer From ATP: What Can Be Learnt?

  2016cites this paper
• Homoserine kinase in Chlamydomonas reinhardtii: biochemical characterization and expression pattern

  2016influential citation
• Post-transcriptional Regulation of Luteinizing Hormone Receptor mRNA Expression in the Ovary

  2016cites this paper
• Environmental Phosphorus Recovery Based on Molecular Bioscavengers: From Quantum Mechanics to Continuum Physics

  2016cites this paper
• Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes.

  2016cites this paper
• Post-transcriptional Mechanisms in Endocrine Regulation

  2016cites this paper
• Mycobacterium tuberculosis kinases as potential drug targets: production of recombinant kinases in E. coli for functional characterization and enzyme inhibition screening against the medicinal plant Pelargonium sidoides

  2015influential citation
• Structural analysis of mevalonate‐3‐kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases

  2015cites this paper
• Mechanistic aspects of carotenoid biosynthesis.

  2014cites this paper
• Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei

  2014cites this paper
• Plant Responses to Bacterial N-Acyl l-Homoserine Lactones are Dependent on Enzymatic Degradation to l-Homoserine

  2014cites this paper
• The Role of Arg228 in the phosphorylation of galactokinase: The mechanism of GHMP kinases by QM/MM studies

  2013cites this paper
• pH‐rate profiles support a general base mechanism for galactokinase (Lactococcus lactis)

  2013cites this paper
• Structural and biochemical perspectives in plant isoprenoid biosynthesis

  2013cites this paper
• Recognition of nontrivial remote homology relationships involving proteins of Helicobacter pylori: implications for function recognition.

  2013cites this paper
• Role of Arg228 in the phosphorylation of galactokinase: the mechanism of GHMP kinases by quantum mechanics/molecular mechanics studies.

  2013cites this paper
• Functional and applied aspects of the DOWNY MILDEW RESISTANT 1 and 6 genes in Arabidopsis

  2012cites this paper
• Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

  2012cites this paper
• Design principles underpinning the regulatory diversity of protein kinases

  2012cites this paper
• Molecular simulation and docking studies of Gal1p and Gal3p proteins in the presence and absence of ligands ATP and galactose: implication for transcriptional activation of GAL genes

  2012cites this paper
• Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.

  2012cites this paper
• Crystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.

  2011cites this paper
• Crystal structure of 4‐diphosphocytidyl‐2‐C‐methyl‐D‐erythritol kinase (IspE) from Mycobacterium tuberculosis

  2011cites this paper
• The role of the active site residues in human galactokinase: implications for the mechanisms of GHMP kinases.

  2011cites this paper
• The methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis as a target for the development of new drugs against tuberculosis.

  2011cites this paper
• Mechanistic studies on human N-acetylgalactosamine kinase

  2010cites this paper
• Molecular regulation of gonadotropin receptor expression: relationship to sterol metabolism.

  2010cites this paper
• Structural and Functional Studies of QdtC: an N -Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-Dideoxy-α - D -Glucose ¶

  2009cites this paper
• Interactions of Burkholderia cenocepacia and other Burkholderia cepacia complex bacteria with epithelial and phagocytic cells.

  2009cites this paper
• Structural and Functional Studies of QdtC : An N-Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3 , 6-dideoxy-RD-glucose † , ‡

  2009cites this paper
• Kinetic and Functional Analysis of l-Threonine Kinase, the PduX Enzyme of Salmonella enterica*

  2009cites this paper
• Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family.

  2009cites this paper
• Structural and functional studies of QdtC: an N-acetyltransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.

  2009cites this paper
• Downy Mildew Resistance in Arabidopsis by Mutation of HOMOSERINE KINASE[W]

  2009cites this paper
• Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.

  2009cites this paper
• The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.

  2009cites this paper
• Biochemical and mutational analysis of coenzyme B12 biosynthesis

  2009cites this paper
• Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

  2009cites this paper
• Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition

  2008cites this paper
• Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.

  2008cites this paper
• Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase – ligand recognition in a template for antimicrobial drug discovery

  2008cites this paper
• Genetic Evidence for Sites of Interaction Between the Gal3 and Gal80 Proteins of the Saccharomyces cerevisiae GAL Gene Switch

  2008influential citation
• High-Throughput Screening for Human Galactokinase Inhibitors

  2008cites this paper
• Phosphate recognition in structural biology.

  2007cites this paper
• Structural and functional studies of phosphoenolpyruvate carboxykinase

  2007cites this paper
• Molekulare Erkennung von Phosphaten in der Strukturbiologie

  2007cites this paper
• Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate

  2007cites this paper
• Properties and Physiological Functions of UDP-Sugar Pyrophosphorylase in Arabidopsis

  2007cites this paper
• Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase

  2007cites this paper
• Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary.

  2007cites this paper
• A novel post-transcriptional mechanism of regulation of luteinizing hormone receptor expression by an RNA binding protein from the ovary.

  2006cites this paper
• Intragenic Suppression of Gal3C Interaction With Gal80 in the Saccharomyces cerevisiae GAL Gene Switch

  2006cites this paper
• The aspartic acid metabolic pathway, an exciting and essential pathway in plants

  2006cites this paper
• A threonine synthase homolog from a mammalian genome.

  2006cites this paper
• Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implications for signal transduction in the GAL regulon

  2005cites this paper
• Identification of Virulence Determinants for Endocarditis in Streptococcus sanguinis by Signature-Tagged Mutagenesis

  2005cites this paper
• Regulation of Luteinizing Hormone Receptor Expression

  2005cites this paper
• Enterococcus faecalis phosphomevalonate kinase

  2005cites this paper
• The Molecular Architecture of Human N-Acetylgalactosamine Kinase*

  2005cites this paper
• Gonadotropin receptors

  2005cites this paper
• Molecular Structure of Human Galactokinase

  2005cites this paper
• Comparative Modeling and Structural Proteomics

  2005cites this paper