LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Microbiology

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1099/00221287-148-3-763PMID 11882711
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone.

  2002cited by this paper
• Signaling System in Porphyromonas gingivalis Based on a LuxS Protein

  2001influential reference
• Periodontal Pathogens Produce Quorum Sensing Signal Molecules

  2001cited by this paper
• The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal molecule

  2001influential reference
• Shigella flexneri LuxS Quorum-Sensing System Modulates virB Expression but Is Not Essential for Virulence

  2001influential reference
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria.

  2001influential reference
• Porphyromonas gingivalis Gingipains and Adhesion to Epithelial Cells

  2001cited by this paper
• Regulation of the Porphyromonas gingivalis fimA(Fimbrillin) Gene

  2000influential reference
• Intercellular Communication in Helicobacter pylori: luxS Is Essential for the Production of an Extracellular Signaling Molecule

  2000influential reference
• The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl)homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase.

  2000cited by this paper
• Evidence for a Signaling System inHelicobacter pylori: Detection of aluxS-Encoded Autoinducer

  2000influential reference
• Quorum sensing and the population-dependent control of virulence.

  2000cited by this paper
• Generation of lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities.

  2000influential reference
• Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis.

  1999influential reference
• Virulence factors of Porphyromonas gingivalis.

  1999cited by this paper
• How bacteria talk to each other: regulation of gene expression by quorum sensing.

  1999cited by this paper
• Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli.

  1999cited by this paper
• Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production.

  1999influential reference
• Regulation of autoinducer production in Salmonella typhimurium

  1999cited by this paper
• Life Below the Gum Line: Pathogenic Mechanisms ofPorphyromonas gingivalis

  1998cited by this paper
• Quorum sensing in Escherichia coli and Salmonella typhimurium.

  1998influential reference
• 6.12 Detection, Purification, and Synthesis of n-acylhomoserine Lactone Quorum Sensing Signal Molecules

  1998cited by this paper
• Regulation of Protease Expression inPorphyromonas gingivalis

  1998cited by this paper
• Cloning and expression of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase: identification of the pfs gene product.

  1998influential reference
• Maturation of the Arginine-Specific Proteases of Porphyromonas gingivalis W50 Is Dependent on a Functional prR2 Protease Gene

  1998cited by this paper
• Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing.

  1998cited by this paper
• The prpR1 and prR2 arginine‐specific protease genes of Porphyromonas gingivalis W50 produce five biochemically distinct enzymes

  1997influential reference
• Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones.

  1997cited by this paper
• Multiple colonization defects in a cysteine protease mutant of Porphyromonas gingivalis.

  1997cited by this paper
• Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi

  1997cited by this paper
• Development of a simple chemically defined medium for Porphyromonas gingivalis: requirement for α-ketoglutarate

  1996cited by this paper
• Construction and preliminary characterization of three hemagglutinin mutants of Porphyromonas gingivalis

  1996cited by this paper
• Periodontal Infection as a Possible Risk Factor for Preterm Low Birth Weight.

  1996cited by this paper
• Periodontal Disease and Cardiovascular Disease.

  1996cited by this paper
• The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats

  1996cited by this paper
• Periodontal disease and cardiovascular disease.

  1996cited by this paper
• Development of a simple chemically defined medium for Porphyromonas gingivalis: requirement for alpha-ketoglutarate.

  1996cited by this paper
• Periodontal infection as a possible risk factor for preterm low birth weight.

  1996cited by this paper
• Genetic evidence for the relationship of Porphyromonas gingivalis cysteine protease and hemagglutinin activities.

  1996cited by this paper
• Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-gingipain) in Porphyromonas gingivalis: structural relationship with the arginine-specific cysteine proteinase (Arg-gingipain).

  1996cited by this paper
• Molecular Cloning and Structural Characterization of the Arg-gingipain Proteinase of Porphyromonas gingivalis

  1995cited by this paper
• Construction and Characterization of Arginine-specific Cysteine Proteinase (Arg-gingipain)-deficient Mutants of Porphyromonas gingivalis

  1995cited by this paper
• Characterization of a Tn4351-generated hemin uptake mutant of Porphyromonas gingivalis: evidence for the coordinate regulation of virulence factors by hemin

  1995cited by this paper
• Characterization, genetic analysis, and expression of a protease antigen (PrpRI) of Porphyromonas gingivalis W50

  1995cited by this paper
• Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway

  1994influential reference
• Cloning and characterization of a new protease gene (prtH) from Porphyromonas gingivalis

  1994cited by this paper
• A novel strategy for the isolation of luxl homologues: evidence for the widespread distribution of a LuxR:Luxl superfamily in enteric bacteria

  1993cited by this paper
• Isolation and characterization of a cloned Porphyromonas gingivalis hemagglutinin from an avirulent strain of Salmonella typhimurium

  1993cited by this paper
• Porphyromonas gingivalis virulence in mice: induction of immunity to bacterial components

  1992cited by this paper
• Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes

  1991cited by this paper
• Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria

  1990cited by this paper
• Ecological events in subgingival dental plaque with reference to bacteroides and fusobacterium species

  1989cited by this paper
• Biology of asaccharolytic black-pigmented Bacteroides species.

  1988cited by this paper
• pHG165: a pBR322 copy number derivative of pUC8 for cloning and expression.

  1986cited by this paper
• Degradation of immunoglobulins A2, A2, and G by suspected principal periodontal pathogens

  1981cited by this paper
• Rapid isolation of high molecular weight plant DNA.

  1980cited by this paper
• Induction of luciferase synthesis in Beneckea harveyi by other marine bacteria

  1979influential reference

• AI-2 Production in Fusobacterium nucleatum Is Subspecies-Specific and Uncoupled from Quorum Sensing

  2026cites this paper
• Ferulic acid suppresses Porphyromonas gingivalis biofilm formation via the inhibition of autoinducer-2 production and receptor activity.

  2025cites this paper
• N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque

  2025influential citation
• Transcriptional modulation of Porphyromonas gingivalis biofilms on titanium-copper implant surfaces

  2025cites this paper
• Lipoteichoic acid from a canine probiotic strain Lacticaseibacillus rhamnosus possesses anti-biofilm capacity against clinically isolated canine periodontopathic Porphyromonas species.

  2025cites this paper
• Understanding Quorum-Sensing and Biofilm Forming in Anaerobic Bacterial Communities

  2024cites this paper
• Silent signals: how N-acyl homoserine lactones drive oral microbial behaviour and health outcomes

  2024cites this paper
• N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque

  2024cites this paper
• Characterization of AI-2/LuxS quorum sensing system in biofilm formation, pathogenesis of Streptococcus equi subsp. zooepidemicus

  2024cites this paper
• Dysbiotic changes in the intestines under the influence of exogenous biological determinants

  2023cites this paper
• Evaluation of hydrocortisone as a strain-dependent growth-regulator of Porphyromonasgingivalis.

  2023cites this paper
• Lactobacillus reuteri for chronic periodontitis: focus on underlying mechanisms and future perspectives

  2023cites this paper
• The quorum quenching enzyme Aii20J modifies in vitro periodontal biofilm formation

  2023influential citation
• Interplay between Porphyromonas gingivalis Hemophore-Like Protein HmuY and Kgp/RgpA Gingipains Plays a Superior Role in Heme Supply

  2023cites this paper
• Combining molecular modelling and experimental approaches to gain mechanistic insights into the LuxP drug target in Streptococcus pyogens

  2023cites this paper
• Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis

  2023cites this paper
• Quorum Sensing in Oral Biofilms: Influence on Host Cells

  2023cites this paper
• Anti-biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas gingivalis

  2022cites this paper
• Microbiome and the inflammatory pathway in peri-implant health and disease with an updated review on treatment strategies

  2022cites this paper
• Candidate Phyla Radiation, an Underappreciated Division of the Human Microbiome, and Its Impact on Health and Disease

  2022cites this paper
• LuxS modulates motility and secretion of extracellular protease in fish pathogen Vibrio harveyi.

  2021cites this paper
• Functionalizing nanoparticles with CafA protein to target BAR peptide for oral delivery applications

  2021cites this paper
• Catechin as the Most Efficient Bioactive Compound from Azadirachta indica with Antibiofilm and Anti-quorum Sensing Activities Against Dental Biofilm: an In Vitro and In Silico Study

  2021influential citation
• Quorum sensing systems as a new target to prevent biofilm-related oral diseases.

  2020cites this paper
• Probiotics alter biofilm formation and the transcription of Porphyromonas gingivalis virulence-associated genes

  2020cites this paper
• Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities.

  2020cites this paper
• Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update

  2020cites this paper
• A novel gingipain regulatory gene in Porphyromonas gingivalis mediates host cell detachment and inhibition of wound closure

  2020cites this paper
• Acyl homoserine lactone-mediated quorum sensing in the oral cavity: a paradigm revisited

  2020cites this paper
• Comparative gene expression analysis of planktonic Porphyromonas gingivalis ATCC 33277 in the presence of a growing biofilm versus planktonic cells

  2019cites this paper
• Quorum sensing: A molecular cell communication in bacterial cells

  2019cites this paper
• Short-Chain N-Acylhomoserine Lactone Quorum-Sensing Molecules Promote Periodontal Pathogens in In Vitro Oral Biofilms

  2019cites this paper
• Methods for the Detection and Quantification of Quorum-Sensing Signals in Food Spoilage

  2019cites this paper
• Quorum Sensing and Biofilm Formation by Oral Pathogenic Microbes in the Dental Plaques: Implication for Health and Disease

  2019cites this paper
• Quorum Sensing Modulates the Epibiotic-Parasitic Relationship Between Actinomyces odontolyticus and Its Saccharibacteria epibiont, a Nanosynbacter lyticus Strain, TM7x

  2018cites this paper
• Effects of sub-minimum inhibitory concentrations of lemon essential oil on the acid tolerance and biofilm formation of Streptococcus mutans.

  2018cites this paper
• The Discovery, Synthesis, and Characterization of Biological Signaling Molecules and Signaling Disruptors

  2017cites this paper
• New approaches to combat Porphyromonas gingivalis biofilms

  2017cites this paper
• In Vivo Inhibition of Porphyromonas gingivalis Growth and Prevention of Periodontitis With Quorum-Sensing Inhibitors.

  2016cites this paper
• The relationship between oral malodour and chronic periodontitis : role of volatile sulfur compounds

  2016cites this paper
• Human Oral Multi-species Biofilms : Bacterial Communities in Health and Disease

  2016cites this paper
• Bacterial interactions in pathogenic subgingival plaque.

  2016cites this paper
• Rapid method of luxS and pfs gene inactivation in enterotoxigenic Escherichia coli and the effect on biofilm formation.

  2016cites this paper
• The interplay between iron, haem and manganese in Porphyromonas gingivalis

  2015cites this paper
• LuxS signaling in Porphyromonas gingivalis-host interactions.

  2015cites this paper
• Regulation of Spoilage‐Related Activities of Shewanella putrefaciens and Shewanella baltica by an Autoinducer‐2 Analogue, (Z)‐5‐(Bromomethylene)furan‐2(5H)‐One

  2015cites this paper
• Proteomic and transcriptional analysis of interaction between oral microbiota Porphyromonas gingivalis and Streptococcus oralis.

  2015cites this paper
• Bacillus anthracis and Other Bacillus Species

  2015cites this paper
• Response of Alkaliphilic Bacteria to Aromatic Amines

  2015cites this paper
• Quorum Sensing Signal Production and Microbial Interactions in a Polymicrobial Disease of Corals and the Coral Surface Mucopolysaccharide Layer

  2014cites this paper
• Biofilm Control Strategies in Dental Health

  2014cites this paper
• Mutation design and strain background influence the phenotype of Escherichia coli luxS mutants

  2013cites this paper
• Probiotics and their Potential use in Wound Treatment

  2013cites this paper
• Investigating the effects of oral microbial biofilms on oral epithelial cells

  2013cites this paper
• Streptococcus intermedius can module the expression of some virulence factors in Porphyromonas gingivalis

  2012cites this paper
• Modelación por homología de la proteína Luxs de Porphyromonas gingivalis cepa W83

  2012cites this paper
• Furanone Derivatives from Terrestrial Streptomyces spp

  2012cites this paper
• LsrR-Mediated Quorum Sensing Controls Invasiveness of Salmonella typhimurium by Regulating SPI-1 and Flagella Genes

  2012cites this paper
• Synthesis, Evaluation and Applications of Biologically Significant Molecules and their Analogues

  2012cites this paper
• Disrupting the luxS quorum sensing gene does not significantly affect Bacillus anthracis virulence in mice or guinea pigs

  2012cites this paper
• Long Chain N-acyl Homoserine Lactone Production by Enterobacter sp. Isolated from Human Tongue Surfaces

  2012cites this paper
• Systems-level characterization and reconstitution of genetic regulatory networks in Escherichia coli for rational strain optimization : towards improved bioprocesses.

  2012cites this paper
• Microbial chemical signaling: a current perspective

  2012cites this paper
• Thiophenones inhibit Staphylococcus epidermidis biofilm formation at nontoxic concentrations.

  2012cites this paper
• REGULATION OF TOXIN SYNTHESIS BY CLOSTRIDIUM DIFFICILE

  2012cites this paper
• Deep Sequencing of Porphyromonas gingivalis and Comparative Transcriptome Analysis of a LuxS Mutant

  2012cites this paper
• N-Acyl Homoserine Lactone Production by Klebsiella pneumoniae Isolated from Human Tongue Surface

  2012influential citation
• Alternative Autoinducer-2 Quorum-Sensing Response Circuits: Impact on Microbial Community Development

  2011cites this paper
• Exposure of P. gingivalis to noradrenaline reduces bacterial growth and elevates ArgX protease activity.

  2011cites this paper
• The identification and characterisation of PPIases from Burkholderia pseudomallei and Burkholderia thailandensis

  2011cites this paper
• Dental plaque biofilms: communities, conflict and control.

  2011cites this paper
• Streptococcus intermedius trigger quorum-sensing genes in Porphyromonas gingivalis

  2010cites this paper
• Quorum sensing regulation of biofilm growth and gene expression by oral bacteria and periodontal pathogens.

  2010cites this paper
• Synthetic furanones and inhibition of biofilm formation

  2009cites this paper
• Microbial quorum sensing: a tool or a target for antimicrobial therapy?

  2009cites this paper
• Distinct roles of long/short fimbriae and gingipains in homotypic biofilm development by Porphyromonas gingivalis

  2009cites this paper
• Quorum Sensing based Biofouling Control in Membrane Bioreactor for Advanced Water Treatment

  2009cites this paper
• Bacterial Interactions in Dental Biofilm Development

  2009cites this paper
• Insights into the role of quorum sensing in food spoilage.

  2008cites this paper
• Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria

  2008cites this paper
• Porphyromonas gingivalis HmuY and HmuR: further characterization of a novel mechanism of heme utilization

  2008cites this paper
• Presence of Quorum-sensing Systems Associated with Multidrug Resistance and Biofilm Formation in Bacteroides fragilis

  2008cites this paper
• Environmental and genetic factors leading to Mycobacterium avium biofilm formation

  2008cites this paper
• A New Look at Secondary Metabolites

  2008cites this paper
• The luxS Gene Is Involved in AI-2 Production, Pathogenicity, and Some Phenotypes in Erwinia amylovora

  2008cites this paper
• Photoproteins as Reporters in Whole‐cell Sensing

  2008cites this paper
• Quorum Sensing by the Bacterial Signal Autoinducer-2: Phylogenetic Distribution of the Synthesis Gene LuxS, and its Role in Shewanella oneidensis

  2008cites this paper
• Quorum sensing in Serratia.

  2007cites this paper
• Synthetic bromated furanone inhibits autoinducer-2-mediated communication and biofilm formation in oral streptococci.

  2007cites this paper
• Biodegradation of Aromatic Amines by Alkalophilic Bacteria

  2007cites this paper
• Quorum sensing: fact, fiction, and everything in between.

  2007cites this paper
• Examination of AI-2 quorum sensing System in Prevotella bryantii and Prevotella ruminicola-like strains by using bioluminiscence assay

  2007cites this paper
• Does efficiency sensing unify diffusion and quorum sensing?

  2007cites this paper
• Implication of quorum sensing in Salmonella virulence : the luxS gene is necessary for expression of genes in pathogenicity island 1

  2007cites this paper
• Implication of Quorum Sensing in Salmonella enterica Serovar Typhimurium Virulence: the luxS Gene Is Necessary for Expression of Genes in Pathogenicity Island 1

  2007cites this paper
• Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria

  2007cites this paper
• Type II quorum sensing regulates virulence in Erwinia carotovora ssp. carotovora.

  2006cites this paper
• Genetic and proteomic analysis of the role of luxS in the enteric phytopathogen, Erwinia carotovora.

  2006influential citation
• Bacterial interactions and successions during plaque development.

  2006cites this paper
• Communication in bacteria: an ecological and evolutionary perspective

  2006cites this paper