Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Oncogene

• Publication date

  2008-05-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1210994PMID 18084324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cdc7 Is an Active Kinase in Human Cancer Cells Undergoing Replication Stress*

  2007influential reference
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• Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.

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• Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases*

  2006influential reference
• SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

  2006cited by this paper
• Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin*♦

  2006cited by this paper
• A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.

  2006cited by this paper
• Hsk1-Dfp1/Him1, the Cdc7-Dbf4 Kinase in Schizosaccharomyces pombe, Associates with Swi1, a Component of the Replication Fork Protection Complex*

  2005influential reference
• Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.

  2005cited by this paper
• Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 Are Components of a Novel S-Phase Response Pathway to Alkylation Damage

  2005cited by this paper
• Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
• Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

  2004cited by this paper
• Swi1 and Swi3 Are Components of a Replication Fork Protection Complex in Fission Yeast

  2004cited by this paper
• Chk1 in the DNA damage response: conserved roles from yeasts to mammals.

  2004influential reference
• Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells

  2004cited by this paper
• Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.

  2004influential reference
• Regulation of DNA replication by ATR: signaling in response to DNA intermediates.

  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Chk1 and Chk2 kinases in checkpoint control and cancer.

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  2003influential reference
• Replication Checkpoint Protein Mrc1 Is Regulated by Rad3 and Tel1 in Fission Yeast

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• Genomic instability and endoreduplication triggered by RAD17 deletion.

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  2001cited by this paper
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  2001influential reference
• Mrc1 transduces signals of DNA replication stress to activate Rad53

  2001influential reference
• Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.

  2001influential reference
• Cell cycle checkpoint signaling through the ATM and ATR kinases.

  2001cited by this paper
• Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.

  2000cited by this paper
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  2000influential reference
• Human Cdc7-related Kinase Complex

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• Cdc7p–Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

  1999influential reference
• A Novel Growth- and Cell Cycle-Regulated Protein, ASK, Activates Human Cdc7-Related Kinase and Is Essential for G1/S Transition in Mammalian Cells

  1999influential reference
• Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase.

  1999influential reference
• A Fission Yeast Gene,him1+/dfp1+, Encoding a Regulatory Subunit for Hsk1 Kinase, Plays Essential Roles in S-Phase Initiation as Well as in S-Phase Checkpoint Control and Recovery from DNA Damage

  1999influential reference

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  2025cites this paper
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  2018cites this paper
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