Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Allergy and Clinical Immunology

• Publication date

  2010-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jaci.2009.09.011PMID 19969339
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine.

  2015cited by this paper
• A Holy Grail of asthma management: toward understanding how long‐acting β2‐adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

  2008cited by this paper
• Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells.

  2008cited by this paper
• Long-Acting β2-Adrenoceptor Agonists Synergistically Enhance Glucocorticoid-Dependent Transcription in Human Airway Epithelial and Smooth Muscle Cells

  2008cited by this paper
• Global strategy for asthma management and prevention: GINA executive summary

  2008cited by this paper
• Budesonide/formoterol maintenance and reliever therapy: impact on airway inflammation in asthma

  2008cited by this paper
• The synergistic interactions of allergic lung inflammation and intratracheal cationic protein.

  2008cited by this paper
• Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration.

  2008cited by this paper
• Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007.

  2007cited by this paper
• Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma.

  2007cited by this paper
• Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma

  2007cited by this paper
• Clinical relevance of airway remodelling in airway diseases

  2007cited by this paper
• The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge.

  2007cited by this paper
• Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge.

  2006cited by this paper
• Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down.

  2006cited by this paper
• Investigative bronchoprovocation and bronchoscopy in airway diseases.

  2005cited by this paper
• Lung myofibroblasts as targets of salmeterol and fluticasone propionate : inhibition of α-SMA and NF-κB

  2005cited by this paper
• Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of alpha-SMA and NF-kappaB.

  2005cited by this paper
• Differences in airway remodeling between subjects with severe and moderate asthma.

  2005cited by this paper
• Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma.

  2005cited by this paper
• Airway wall remodelling: the influence of corticosteroids

  2005cited by this paper
• Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study.

  2004cited by this paper
• Methods in molecular medicine

  2004cited by this paper
• Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression.

  2004cited by this paper
• Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells.

  2004cited by this paper
• Migration of airway smooth muscle cells.

  2003cited by this paper
• Collagen‐induced resistance to glucocorticoid anti‐mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airway

  2003cited by this paper
• Contractile activity and smooth muscle alpha-actin organization in thrombin-induced human lung myofibroblasts.

  2003cited by this paper
• Airway structural alterations selectively associated with severe asthma.

  2003cited by this paper
• Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment.

  2003cited by this paper
• Mast-cell infiltration of airway smooth muscle in asthma.

  2002cited by this paper
• Effects of montelukast and budesonide on airway responses and airway inflammation in asthma.

  2002cited by this paper
• Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial.

  2001cited by this paper
• Rho-Kinase–Mediated Contraction of Isolated Stress Fibers

  2001cited by this paper
• The Myofibroblast: An Assessment of Controversial Issues and a Definition Useful in Diagnosis and Research

  2001cited by this paper
• Remodeling in asthma and chronic obstructive lung disease.

  2001cited by this paper
• Human airway inflammation : sampling techniques and analytical protocols

  2001cited by this paper
• Asthma. From bronchoconstriction to airways inflammation and remodeling.

  2000cited by this paper
• Effect of methacholine challenge on cellular composition of sputum induction

  1999cited by this paper
• Repeatability of allergen-induced airway inflammation.

  1999cited by this paper
• An antiinflammatory effect of salmeterol, a long-acting beta(2) agonist, assessed in airway biopsies and bronchoalveolar lavage in asthma.

  1999cited by this paper
• Asthma quality of life during 1 year of treatment with budesonide with or without formoterol.

  1999cited by this paper
• The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma.

  1999cited by this paper
• Asthma pathogenesis and allergen-induced late responses.

  1998cited by this paper
• The myofibroblast: a quarter century after its discovery.

  1998cited by this paper
• Potential masking effects of salmeterol on airway inflammation in asthma.

  1998cited by this paper
• Repeatability of measures of inflammatory cell number in bronchial biopsies in atopic asthma.

  1997cited by this paper
• Myofibroblast involvement in the allergen-induced late response in mild atopic asthma.

  1997cited by this paper
• Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.

  1997cited by this paper
• Measurement of inflammatory indices in induced sputum: effects of selection of sputum to minimize salivary contamination.

  1996cited by this paper
• Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids.

  1996cited by this paper
• Effects of inhaled budesonide on allergen-induced airway responses and airway inflammation.

  1996cited by this paper
• Spontaneous and induced sputum to measure indices of airway inflammation in asthma.

  1996cited by this paper
• Reproducibility of allergen-induced early and late asthmatic responses.

  1995cited by this paper
• Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group.

  1994cited by this paper
• The structure of large and small airways in nonfatal and fatal asthma.

  1993cited by this paper
• Functional significance of increased airway smooth muscle in asthma and COPD.

  1993cited by this paper
• Small airways dimensions in asthma and in chronic obstructive pulmonary disease.

  1993cited by this paper
• Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects.

  1993cited by this paper
• Use of induced sputum cell counts to investigate airway inflammation in asthma.

  1992cited by this paper
• A model of airway narrowing in asthma and in chronic obstructive pulmonary disease.

  1992cited by this paper
• The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary disease.

  1991cited by this paper
• Smooth muscle differentiation in scleroderma fibroblastic cells.

  1990cited by this paper
• A model of the mechanics of airway narrowing.

  1990cited by this paper
• The mechanics of airway narrowing in asthma.

  1989cited by this paper
• Cellular events in the bronchi in mild asthma and after bronchial provocation.

  1989cited by this paper
• Late asthmatic responses.

  1987cited by this paper
• Mechanics of airway narrowing.

  1986cited by this paper
• Reproducibility and comparison of responses to inhaled histamine and methacholine.

  1978cited by this paper
• Bronchial reactivity to inhaled histamine: a method and clinical survey

  1977cited by this paper

• NS-229, a novel Janus kinase 1 inhibitor, ameliorates eosinophilic vasculitis in an ovalbumin-induced mouse model by modulating multiple cytokine signaling pathways.

  2026cites this paper
• Mechanistic analysis of oral liquid in the treatment of asthma based on network pharmacology and machine learning

  2026cites this paper
• Pathobiology and Regulation of Eosinophils, Mast Cells, and Basophils in Allergic Asthma

  2025cites this paper
• YAP as a potential therapeutic target for myofibroblast formation in asthma

  2025cites this paper
• A Simulation Study of the Effect of Clinical Characteristics and Treatment Choice on Reliever Medication Use, Symptom Control and Exacerbation Risk in Moderate–Severe Asthma

  2024cites this paper
• Impact of ongoing treatment with inhaled corticosteroids during specific inhalation challenges for diagnosing occupational asthma.

  2024cites this paper
• Rhinovirus induces airway remodeling: what are the physiological consequences?

  2023cites this paper
• Executive summary: Japanese guidelines for adult asthma (JGL) 2021.

  2023cites this paper
• Retrospective Analysis of the Starting Dose of Combined ICS/LABA for Cough-variant Asthma and Cough-predominant Asthma

  2022cites this paper
• The Impact of Corticosteroids on Human Airway Smooth Muscle Contractility and Airway Hyperresponsiveness: A Systematic Review

  2022cites this paper
• EAACI position paper on the clinical use of the bronchial allergen challenge: Unmet needs and research priorities

  2022cites this paper
• Allergen provocation tests in respiratory research: building on 50 years of experience

  2022cites this paper
• Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma

  2022cites this paper
• Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty

  2021cites this paper
• Role of Airway Smooth Muscle in Inflammation Related to Asthma and COPD.

  2021cites this paper
• Recent advances in the development of microparticles for pulmonary administration.

  2020cites this paper
• Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells

  2020cites this paper
• Chemocentric Informatics Analysis: Dexamethasone Versus Combination Therapy for COVID-19

  2020cites this paper
• Towards a personalised treatment approach for asthma attacks

  2020cites this paper
• Effects of β2-adrenergic agonists on house dust mite-induced adhesion, superoxide anion generation, and degranulation of human eosinophils

  2020cites this paper
• Pharmacological Treatment of Fibrosis: a Systematic Review of Clinical Trials

  2020cites this paper
• Epithelial mesenchymal transition in respiratory disease. Fact or fiction.

  2020cites this paper
• The Aftermath of Bronchoconstriction

  2019cites this paper
• Bitter Taste Receptors for Asthma Therapeutics

  2019cites this paper
• The role of airway myofibroblasts in asthma.

  2019cites this paper
• Inhibition of airway remodeling and inflammatory response by Icariin in asthma

  2019cites this paper
• Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs.

  2018cites this paper
• Giants in Chest Medicine: Professor Emeritus Elizabeth F. Juniper, MCSP, MSc.

  2018cites this paper
• The beclomethasone anti‐inflammatory effect occurs in cell/mediator‐dependent manner and is additively enhanced by formoterol: NFkB, p38, PKA analysis

  2018cites this paper
• Asthma Exacerbations: Pathogenesis, Prevention, and Treatment

  2017cites this paper
• Giants in Chest Medicine: Paul M. O'Byrne, MBBCh, FCCP.

  2017cites this paper
• Epigallocatechin-3-gallate inhibits inflammation and epithelial-mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma

  2017cites this paper
• Regulation of human airway smooth muscle cell migration and relevance to asthma

  2017influential citation
• Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.

  2017cites this paper
• Mast cell and eosinophil surface receptors as targets for anti‐allergic therapy

  2017cites this paper
• Role of Regulatory T cells in Airway Inflammation in Asthma.

  2017cites this paper
• An Official American Thoracic Society Research Statement: Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling

  2017cites this paper
• Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration

  2017cites this paper
• Assessment of anti-inflammatory effect from addition of a long-acting beta-2 agonist to inhaled corticosteroid.

  2016cites this paper
• Cell Jamming in the Airway Epithelium.

  2016cites this paper
• Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.

  2016cites this paper
• STATE OF THE ART Cell Jamming in the Airway Epithelium

  2016cites this paper
• Bradykinin B2 receptor expression in the bronchial mucosa of allergic asthmatics: the role of NF‐kB

  2016cites this paper
• Vitamin D Supplementation Reduces Induction of Epithelial-Mesenchymal Transition in Allergen Sensitized and Challenged Mice

  2016cites this paper
• STUDY THE ROLE OF VITAMIN D IN THE PATHOPHYSIOLOGY OF SEVERE ASTHMA

  2016cites this paper
• Airway remodeling is reversed by aerobic training in a murine model of chronic asthma

  2015cites this paper
• Novel binuclear μ-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential.

  2015cites this paper
• Acetylcholine beyond bronchoconstriction: a regulator of inflammation and remodeling

  2015cites this paper
• Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects

  2015cites this paper
• Allergen-induced airway responses

  2015cites this paper
• A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses.

  2015cites this paper
• Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation.

  2015cites this paper
• Why use long acting bronchodilators in chronic obstructive lung diseases? An extensive review on formoterol and salmeterol.

  2015cites this paper
• Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling.

  2015cites this paper
• Putting the Squeeze on Airway Epithelia.

  2015cites this paper
• Anti-mitogenic Effect of Bitter Taste Receptor Agonists on Airway Smooth Muscle Cells

  2015cites this paper
• Research and development of bronchodilators for asthma and COPD with a focus on G protein/KCa channel linkage and β2-adrenergic intrinsic efficacy.

  2015cites this paper
• Bronchopulmonary lymph nodes and large airway cell trafficking in patients with fatal asthma.

  2015cites this paper
• Efficacy of inhaled corticosteroids for patients with asthma: a descriptive review of randomized controlled trials

  2015cites this paper
• Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.

  2015cites this paper
• Возможности контроля пыльцевой бронхиальной астмы с помощью режима единого ингалятора: случай из практики

  2015cites this paper
• Bronchoconstriction and airway biology: potential impact and therapeutic opportunities.

  2015cites this paper
• Concomitant inhibition of primary equine bronchial fibroblast proliferation and differentiation by selective β2-adrenoceptor agonists and dexamethasone.

  2014cites this paper
• Virus-induced modulation of lower airway diseases: Pathogenesis and pharmacologic approaches to treatment

  2014cites this paper
• Technical and physiological determinants of airway smooth muscle mass in endobronchial biopsy samples of asthmatic horses.

  2014cites this paper
• Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells

  2014cites this paper
• Extracellular matrix composition is modified by β₂-agonists through cAMP in COPD.

  2014cites this paper
• Intranasal curcumin attenuates airway remodeling in murine model of chronic asthma.

  2014cites this paper
• Análise histológica dos linfonodos broncopulmonares na asma fatal

  2014cites this paper
• Contribution des isoformes de la myosine à l'obstruction respiratoire dans le souffle chez le cheval

  2014cites this paper
• Режим единого ингалятора в ступенчатой терапии бронхиальной астмы: изменения GINA 2014

  2014cites this paper
• Inhaled allergen challenge in assessment of biologics for asthma

  2014cites this paper
• Single inhaler strategy in stepwise therapy of bronchial asthma: GINA 2014 update

  2014cites this paper
• Vitamin D regulating TGF-β induced epithelial-mesenchymal transition

  2014cites this paper
• Compartmental and Temporal Dynamics of Chronic Inflammation and Airway Remodelling in a Chronic Asthma Mouse Model

  2014cites this paper
• Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma

  2014cites this paper
• Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.

  2014cites this paper
• Pulmonary , gastrointestinal and urogenital pharmacology Concomitant inhibition of primary equine bronchial fi broblast proliferation and differentiation by selective β 2-adrenoceptor agonists and dexamethasone

  2014cites this paper
• Effects of Baicalin on Airway Remodeling in Asthmatic Mice

  2013cites this paper
• Chemokine profiles in blood associated with delayed asthmatic response to allergen challenge.

  2013cites this paper
• Modulation of allergen-induced bronchoconstriction by fluticasone furoate and vilanterol alone or in combination

  2013cites this paper
• Could FEV1 decline have a role in daily clinical practice for asthma monitoring?

  2013cites this paper
• Different healing process of esophageal large mucosal defects by endoscopic mucosal dissection between with and without steroid injection in an animal model

  2013cites this paper
• Effect of Formoterol on Eosinophil Trans-Basement Membrane Migration Induced by Interleukin-8-Stimulated Neutrophils

  2013cites this paper
• Inhaled allergen bronchoprovocation tests.

  2013cites this paper
• A mouse model for evaluating the contribution of fibrocytes and myofibroblasts to airway remodeling in allergic asthma.

  2013cites this paper
• Effects of inhaled corticosteroids on the dual asthmatic response.

  2013cites this paper
• Development and validation of primary human myometrial cell culture models to study pregnancy and labour

  2013cites this paper
• The pharmacological modulation of allergen-induced asthma

  2012cites this paper
• Motility, survival, and proliferation.

  2012cites this paper
• Airway smooth muscle in asthma: just a target for bronchodilation?

  2012cites this paper
• Diagnostic tools assessing airway remodelling in asthma.

  2012cites this paper
• Mechanisms Underlying the Immune Response to Inhaled House Dust Mite

  2012cites this paper
• Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase.

  2012cites this paper
• Toll‐like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma

  2012cites this paper
• Inhalation of Budesonide Formoterol Increases Diaphragm Muscle

  2012cites this paper
• Effects of budesonide/formoterol combination therapy versus budesonide alone on airway dimensions in asthma

  2012cites this paper
• Nanocluster budesonide formulations enhance drug delivery through endotracheal tubes.

  2012cites this paper
• Corticosteroid‐induced gene expression in allergen‐challenged asthmatic subjects taking inhaled budesonide

  2012influential citation
• Combined fluticasone furoate/vilanterol reduces decline in lung function following inhaled allergen 23 h after dosing in adult asthma: a randomised, controlled trial

  2012influential citation