UV‐B‐type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas

No abstract is available for this paper.

• Publication year

  2002

• Venue

  International Journal of Cancer

• Publication date

  2002-05-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.10321PMID 11992403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Merkel cell carcinoma

  2004cited by this paper
• Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastases

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin

  2001cited by this paper
• Deregulated expression of c-Myc depletes epidermal stem cells

  2001cited by this paper
• Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization.

  2001cited by this paper
• c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny.

  2001cited by this paper
• Trisomy 6 in Merkel cell carcinoma: a recurrent chromosomal aberration

  2000cited by this paper
• Photocarcinogenesis: UVA vs UVB.

  2000cited by this paper
• Skin cancer in liver transplant recipients

  2000cited by this paper
• Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis.

  2000cited by this paper
• Mutation analysis of P73 and TP53 in Merkel cell carcinoma

  2000cited by this paper
• Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis

  2000cited by this paper
• Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature

  1999cited by this paper
• Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion.

  1999cited by this paper
• Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization.

  1999cited by this paper
• Nonrandom karyotypic features in squamous cell carcinomas of the skin

  1999cited by this paper
• Merkel's cell carcinoma in organ recipients: report of 41 cases.

  1999cited by this paper
• Diagnostic relevance of chromosomal in‐situ hybridization in Merkel cell carcinoma: targeted interphase cytogenetic tumour analyses

  1999cited by this paper
• Deletion monitoring in skin tumors by interphase-FISH using band-specific DNA probes.

  1999cited by this paper
• The role of the FHIT/FRA3B locus in cancer.

  1998cited by this paper
• Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization.

  1998cited by this paper
• Pagetoid Merkel cell carcinoma: epidermal origin of the tumor

  1998cited by this paper
• The INK4a/ARF tumor suppressor: one gene--two products--two pathways.

  1998cited by this paper
• Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization.

  1998cited by this paper
• An FHIT tumor suppressor gene?

  1998cited by this paper
• Immune response associated with nonmelanoma skin cancer.

  1997cited by this paper
• c-Myc promotes differentiation of human epidermal stem cells.

  1997cited by this paper
• Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

  1997cited by this paper
• Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.

  1997cited by this paper
• Sunlight and the onset of skin cancer.

  1997cited by this paper
• Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long‐term culture of the human keratinocyte line HaCaT

  1997cited by this paper
• Deletion mapping of the short arm of chromosome 3 in Merkel cell carcinoma

  1996cited by this paper
• Aberrant FHIT transcripts in Merkel cell carcinoma.

  1996cited by this paper
• Comparative genomic hybridization (CGH) discloses chromosomal and subchromosomal copy number changes in Merkel cell carcinomas

  1996cited by this paper
• Epidemiology of nonmelanoma skin cancer: a review.

  1996cited by this paper
• CDKN2 mutations in melanoma.

  1996cited by this paper
• CDKN2 mutations in melanoma.

  1996cited by this paper
• The immune system in ultraviolet carcinogenesis.

  1996cited by this paper
• Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma.

  1995cited by this paper
• Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.

  1995cited by this paper
• The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma.

  1995cited by this paper
• Point mutations in the N‐ras oncogene in malignant melanoma and congenital naevi

  1994cited by this paper
• Establishment and characterization of two Merkel cell tumor cultures.

  1994cited by this paper
• Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss.

  1994cited by this paper
• Merkel cell carcinoma.

  1993cited by this paper
• A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

  1993cited by this paper
• Codon 12 Harvey‐ras mutations are rare events in non‐melanoma human skin cancer

  1993cited by this paper
• Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

  1993cited by this paper
• Molecular alterations in human skin tumors.

  1992cited by this paper
• Molecular alterations in human skin tumors.

  1992cited by this paper
• Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors.

  1992cited by this paper
• A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

  1991cited by this paper
• Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin.

  1990cited by this paper
• A genetic model for colorectal tumorigenesis.

  1990cited by this paper
• Primary neuroendocrine (Merkel cell?) carcinoma of the skin: I. A clinicopathologic and ultrastructural study of 43 cases

  1985cited by this paper
• Neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias, and neoplasms.

  1985cited by this paper
• Preservation of morphological, functional, and karyotypic traits during long-term culture and in vivo passage of two human skin squamous cell carcinomas.

  1983cited by this paper
• Phenotypic and genotypic characteristics of a cell line from a squamous cell carcinoma of human skin.

  1982cited by this paper
• Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.

  1981cited by this paper
• Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.

  1977cited by this paper
• Trabecular carcinoma of the skin.

  1972cited by this paper

• Histopathological diagnosis and variants of Merkel cell carcinoma

  2026cites this paper
• Clinical, Surgical, and Survival Outcomes of Periocular Merkel Cell Carcinoma: A Retrospective Cohort Analysis.

  2026influential citation
• Understanding Merkel Cell Carcinoma: Pathogenic Signaling, Extracellular Matrix Dynamics, and Novel Treatment Approaches

  2025cites this paper
• Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV

  2025cites this paper
• Merkel Cell Carcinoma and the Eye.

  2024cites this paper
• The Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association with Tumor Stromal Inflammation

  2024cites this paper
• Targeting receptor tyrosine kinase signaling: Avenues in the management of cutaneous squamous cell carcinoma

  2023cites this paper
• Merkel Cell Carcinoma in Kidney Transplant Recipients

  2023cites this paper
• An In Vitro Pilot Study Investigating the Antineoplastic Effects of GP-2250 on Cutaneous Squamous Cell Carcinoma Cell Lines: Preliminary Results

  2023cites this paper
• Knockdown of Simulated-Solar-Radiation-Sensitive miR-205-5p Does Not Induce Progression of Cutaneous Squamous Cell Carcinoma In Vitro

  2023cites this paper
• Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway

  2022cites this paper
• Merkel cell carcinoma.

  2022cites this paper
• Management and Prognosis of Cardiac Metastatic Merkel Cell Carcinoma: A Case–Control Study and Literature Review

  2022cites this paper
• The Current Management of Merkel Carcinoma of the Head and Neck: a Scoping Review

  2022cites this paper
• Distinct Signatures of Genomic Copy Number Variants Define Subgroups of Merkel Cell Carcinoma Tumors

  2021cites this paper
• Merkel Cell Carcinoma from Molecular Pathology to Novel Therapies

  2021cites this paper
• Synthesis of RNA-based gene regulatory devices for redirecting cellular signaling events mediated by p53

  2021cites this paper
• Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers

  2021cites this paper
• Merkel cell carcinoma

  2021cites this paper
• An Extremely Rare Case of Metastatic Merkel Carcinoma of the Liver

  2021cites this paper
• Secondary Immunodeficiency in Hematological Malignancies: Focus on Multiple Myeloma and Chronic Lymphocytic Leukemia

  2021cites this paper
• Merkel Cell Carcinoma

  2021cites this paper
• Viruses and Skin Cancer

  2021cites this paper
• Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

  2020cites this paper
• Gene expression profile identifies distinct molecular subtypes and potential therapeutic genes in Merkel cell carcinoma

  2020cites this paper
• Fibulin-3 Has Anti-Tumorigenic Activities in Cutaneous Squamous Cell Carcinoma.

  2019cites this paper
• Differential Outcomes Among Immunosuppressed Patients With Merkel Cell Carcinoma: Impact of Immunosuppression Type on Cancer-specific and Overall Survival

  2019cites this paper
• Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs

  2019cites this paper
• Merkel Cell Carcinoma Review.

  2019cites this paper
• Wnt Signaling Pathways in Keratinocyte Carcinomas

  2019cites this paper
• Merkel-Zell-Karzinome der Kopf-Hals-Region

  2019cites this paper
• Expression of FOXE 1 in Cutaneous Squamous Cell Carcinoma

  2019cites this paper
• Updates on Merkel Cell Carcinoma.

  2019cites this paper
• Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck

  2018cites this paper
• Merkel cell carcinoma of the eyelid and orbit.

  2018cites this paper
• Application of microarray and quantitative real-time PCR methods in oncology

  2018cites this paper
• Merkel Cell Carcinoma in the HIV-1/AIDS Patient.

  2018cites this paper
• Spontaneous regression of Merkel cell carcinoma.

  2018cites this paper
• Merkelzellkarzinome der Kopf-Hals-Region

  2018influential citation
• Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome

  2017cites this paper
• Merkel cell carcinoma

  2017cites this paper
• Update on Merkel Cell Carcinoma: Epidemiology, Etiopathogenesis, Clinical Features, Diagnosis, and Staging.

  2017cites this paper
• Merkel cell carcinoma: Epidemiology, pathogenesis, diagnosis and therapy

  2017cites this paper
• The interplay of UV and cutaneous papillomavirus infection in skin cancer development

  2017cites this paper
• Update on Merkel Cell Carcinoma: Epidemiology, Etiopathogenesis, Clinical Features, Diagnosis, and Staging.

  2017cites this paper
• Left-sided laterality of Merkel cell carcinoma in a German population: more than just sun exposure

  2017cites this paper
• Pathology of Merkel Cell Carcinoma (Primary Neuroendocrine Carcinoma of the Skin)

  2016cites this paper
• Sox9 is a β-catenin-regulated transcription factor that enhances the colony-forming activity of squamous cell carcinoma cells.

  2016cites this paper
• Merkel cell polyomavirus and human papilloma virus in proliferative skin lesions arising in patients treated with BRAF inhibitors

  2016cites this paper
• WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

  2016cites this paper
• Report on Carcinogens Monograph on Merkel Cell Polyomavirus

  2016cites this paper
• New Perspectives in the Pharmacological Treatment of Non-Melanoma Skin Cancer.

  2016cites this paper
• Combined squamous cell carcinoma and Merkel cell carcinoma of the vulva: Role of human papillomavirus and Merkel cell polyomavirus

  2015cites this paper
• Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy

  2015influential citation
• Correlation of Merkel cell polyomavirus positivity with PDGFRα mutations and survivin expression in Merkel cell carcinoma.

  2015cites this paper
• MERKEL CELL CARCINOMA : ADVANCES IN PATHOGENESIS , DIAGNOSIS AND PROGNOSTIC FACTORS

  2015cites this paper
• Merkel cell carcinoma: emerging biology, current approaches, and future directions.

  2015cites this paper
• Pure versus combined Merkel cell carcinomas: immunohistochemical evaluation of cellular proteins (p53, Bcl-2, and c-kit) reveals significant overexpression of p53 in combined tumors.

  2015influential citation
• Sentinel lymph node biopsy for cutaneous head and neck malignancies

  2015cites this paper
• Wnt‐3a‐activated human fibroblasts promote human keratinocyte proliferation and matrix destruction

  2015cites this paper
• Cutaneous squamous and neuroendocrine carcinoma: genetically and immunohistochemically different from Merkel cell carcinoma

  2015cites this paper
• Joint occurrence of Merkel cell carcinoma and non-Hodgkin lymphomas in four Nordic countries

  2015cites this paper
• Title: Contribution of Beta-HPV Infection and UV-Damage to Rapid-onset Cutaneous Squamous Cell Carcinoma during BRAF-inhibition Therapy Running Title: Beta-HPV and UV-damage in cutaneous SCC during BRAF Therapy

  2015influential citation
• Milestones in the staging, classification, and biology of Merkel cell carcinoma.

  2014cites this paper
• Langerhans Cell Contributions To Ultraviolet Light-Induced Cutaneous Carcinogenesis

  2014cites this paper
• Mutational Analysis of Merkel Cell Carcinoma

  2014influential citation
• Cancer and Infectious Causes

  2014cites this paper
• MALARIA AND SOME POLYOMAVIRUSES (SV40, BK, JC, AND MERKEL CELL VIRUSES)

  2014cites this paper
• Merkel cell carcinoma - recent advances in the biology, diagnostics and treatment.

  2014cites this paper
• Merkel-Zell-Karzinom

  2014cites this paper
• MicroRNA-34a underexpressed in Merkel cell polyomavirus –negative Merkel cell carcinoma tumors

  2014cites this paper
• Subgroups of Merkel cell carcinoma patients defined by young age, immunodeficiency and polyomavirus infection

  2014cites this paper
• Melanotic and non-melanotic malignancies of the face and external ear - A review of current treatment concepts and future options.

  2014cites this paper
• Merkel Cell Carcinoma in Immunosuppressed Patients

  2014cites this paper
• Pathways of Tumor development and progression in Drug-induced Nonmelanoma Skin Cancer: a New Hope or the Next Great Confusion?

  2014cites this paper
• The telomere profile distinguishes two classes of genetically distinct cutaneous squamous cell carcinomas

  2014cites this paper
• Molecular pathology of skin neoplasms of the head and neck.

  2014cites this paper
• GRM1, A POTENTIAL TARGET FOR HUMAN MELANOMA

  2013cites this paper
• Lateral distribution of Merkel cell carcinoma in a nationwide cohort

  2013cites this paper
• Exposure Data 1 . 1 Cell and tissue tropism

  2013cites this paper
• Carcinome de Merkel : (r)évolution

  2013cites this paper
• Basic Science of the Merkel Cell

  2013cites this paper
• The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis

  2013cites this paper
• Chapter 149 – Skin Cancer

  2013cites this paper
• Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

  2013cites this paper
• Merkel Cell Carcinoma

  2013cites this paper
• Epidemiology and Genetics (Including High Risk Patients, Polyomavirus, Prognostic Factors)

  2013cites this paper
• Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential.

  2013cites this paper
• Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.

  2013cites this paper
• Activation of the PI3K/AKT Pathway in Merkel Cell Carcinoma

  2012cites this paper
• Uncommon cutaneous neoplasms of the head and neck.

  2012cites this paper
• Combined intraepidermal neuroendocrine (Merkel cell) and squamous cell carcinoma in situ with CM2B4 negativity and p53 overexpression *

  2012cites this paper
• Merkel cell carcinoma. A review.

  2012cites this paper
• Neuron navigator 3 ( NAV 3 ) gene aberrations in human cancer : copy number variations and target genes

  2012cites this paper
• Recent advances in the understanding of the genetics, etiology, and treatment of Merkel cell carcinoma.

  2012cites this paper
• Neuron navigator 3 (NAV3) gene aberrations in human cancer : copy number changes and target genes

  2012cites this paper
• Merkel cell polyomavirus infection and host defence in patients with Merkel cell carcinoma

  2012cites this paper
• Merkel cell carcinoma - a population-based epidemiological study in Finland with a clinical series of 181 cases.

  2012cites this paper
• Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen

  2012influential citation
• Poliomavírus na oncogénese do carcinoma de Merkel

  2012cites this paper