Azithromycin--review of key chemical, pharmacokinetic and microbiological features.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Journal of Antimicrobial Chemotherapy

• Publication date

  1996-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/JAC/37.SUPPL_C.1PMID 8818841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Preferential concentration of azithromycin in an infected mouse thigh model.

  1993cited by this paper
• Comparison of azithromycin, roxithromycin, and cephalexin penetration kinetics in early and mature abscesses.

  1993influential reference
• Selection of dose regimens of azithromycin .

  1993cited by this paper
• In vitro and in vivo intraleukocytic accumulation of azithromycin (CP-62, 993) and its influence on ex vivo leukocyte chemiluminescence

  1992cited by this paper
• Potentiation of antibacterial activity of azithromycin and other macrolides by normal human serum

  1992cited by this paper
• Mechanism of azithromycin tissue uptake and accumulation: subcellular localization of azithromycin in rat liver.

  1992cited by this paper
• Spectrum of activity of azithromycin

  1991cited by this paper
• Antibiotic tissue penetration and its relevance: models of tissue penetration and their meaning

  1991cited by this paper
• High and prolonged pulmonary tissue concentrations of azithromycin following a single oral dose

  1991cited by this paper
• Pharmacokinetics of azithromycin after single oral dosing of experimental animals

  1991cited by this paper
• Comparison of the acid stability of azithromycin and erythromycin A.

  1990cited by this paper
• Correlation of the extravascular pharmacokinetics of azithromycin with in-vivo efficacy in models of localized infection.

  1990cited by this paper
• Pharmacokinetics of azithromycin in rats and dogs.

  1990cited by this paper
• Pharmacokinetics of antibiotics in tissues and tissue fluids: a review.

  1990cited by this paper
• Azithromycin concentrations at the sites of pulmonary infection.

  1990cited by this paper
• Comparative in-vitro activity of azithromycin and erythromycin against Gram-positive cocci, Haemophilus influenzae and anaerobes.

  1990cited by this paper
• The pharmacokinetics of azithromycin in human serum and tissues.

  1990cited by this paper
• Intracellular accumulation of azithromycin by cultured human fibroblasts

  1990cited by this paper
• Relationship of high tissue concentrations of azithromycin to bactericidal activity and efficacy in vivo.

  1990cited by this paper
• Interaction of azithromycin and human phagocytic cells. Uptake of the antibiotic and the effect on the survival of ingested bacteria in phagocytes.

  1989cited by this paper
• In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection

  1989influential reference
• In vitro and in vivo activity of azithromycin (CP 62,993) against the Mycobacterium avium complex.

  1989cited by this paper
• Comparative antimicrobial activity of the new macrolides againstBorrelia burgdorferi

  1989cited by this paper
• Susceptibility of clinical isolates ofCampylobacter pylori to twenty-one antimicrobial agents

  1988cited by this paper
• The in-vitro activity of CP-62,993 against Haemophilus influenzae, Branhamella catarrhalis, staphylococci and streptococci.

  1988cited by this paper
• In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62,993], and A-56268) on Toxoplasma gondii

  1988cited by this paper
• Comparative in vitro activity of the new oral macrolide azithromycin

  1988cited by this paper
• Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides

  1988cited by this paper
• Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-AZA-9a-homoerythromycin A derivatives; a new class of macrolide antibiotics, the azalides.

  1988cited by this paper
• In vitro activity of azithromycin (CP-62,993), a novel macrolide, against enteric pathogens.

  1988cited by this paper
• Susceptibility of Campylobacter pylori to macrolides and fluoroquinolones.

  1988cited by this paper
• Rate of bactericidal activity for Branhamella catarrhalis of a new macrolide, CP-62,993, compared with that of amoxicillin-clavulanic acid.

  1988cited by this paper
• Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution

  1987cited by this paper
• Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms

  1987cited by this paper
• In-vitro activity of erythromycin, roxithromycin and CP 62993 against common paediatric pathogens.

  1987cited by this paper
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  1985cited by this paper
• Erythromycin: a microbial and clinical perspective after 30 years of clinical use (1).

  1985cited by this paper
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  1978cited by this paper

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• Significant Predictors of Azithromycin in Population Pharmacokinetic Analysis: A Systematic Review

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  2023cites this paper
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  2023cites this paper
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• Targeting malaria parasites with novel derivatives of azithromycin

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