Plasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathway

Flippases that catalyze interleaflet lipid transfer, as well as the stimulatory protein kinase Fpk1, localize to the shmoo tip. Although viable and near-normal morphologically, cells lacking these flippases fail to respond to pheromone due to derangements in PtdIns(4,5)P2 localization, with ensuing effects on the level and/or function of MAPK scaffold protein Ste5.

• Publication year

  2015

• Venue

  Molecular Biology of the Cell

• Publication date

  2015-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E14-07-1193PMID 25378585PMCID 4279224
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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