Injured Nerve Regeneration using Cell-Based Therapies: Current Challenges

This paper reviews the recent research progress in the past several years on promoting peripheral nerve recovery using stem and progenitory cells. The emphasis is placed on studies aimed at assessing various stem cells capable of expressing neurotrophic and growth factors and surviving after implantation in the nerve or a conduit. Approaches to improving nerve conduit design are summarized. The contribution of stem cells to axonal regeneration and neural repair is discussed. The side effects associated with cell-based treatment are highlighted. From the studies reviewed, it is concluded that the fate of transplanted stem cells needs further elucidation in a microenvironment-dependent manner.

• Publication year

  2015

• Venue

  Acta Naturae

• Publication date

  2015-07-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.32607/20758251-2015-7-3-38-47PMID 26483958PMCID 4610163
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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