HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Blood

• Publication date

  2007-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2007-02-073254PMID 17557894PMCID PMC1976368
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of rapamycin on accumulation of alpha-, beta- and gamma-globin mRNAs in erythroid precursor cells from beta-thalassaemia patients.

  2006cited by this paper
• Recombinant human erythropoietin: has treatment reached its full potential?

  2006cited by this paper
• Effects of rapamycin on accumulation of α‐, β‐ and γ‐globin mRNAs in erythroid precursor cells from β‐thalassaemia patients

  2006cited by this paper
• Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure.

  2006cited by this paper
• Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.

  2006cited by this paper
• Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularized microcapsules.

  2005cited by this paper
• Human erythropoietin gene therapy for patients with chronic renal failure.

  2005cited by this paper
• A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells.

  2005cited by this paper
• Ex vivo transduction of human dermal tissue structures for autologous implantation production and delivery of therapeutic proteins.

  2005cited by this paper
• Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

  2005cited by this paper
• Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo.

  2005cited by this paper
• The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes.

  2004cited by this paper
• Treatment of erythropoietin-induced pure red cell aplasia: a retrospective study.

  2004cited by this paper
• Clinical studies with fetal hemoglobin-enhancing agents in sickle cell disease.

  2004cited by this paper
• Autoimmune anemia in macaques following erythropoietin gene therapy.

  2004cited by this paper
• Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor*

  2004cited by this paper
• Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease.

  2004cited by this paper
• Flow cytometric analysis of fetal hemoglobin in erythroid precursors of beta-thalassemia.

  2004cited by this paper
• Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.

  2004cited by this paper
• Erythropoietin gene therapy leads to autoimmune anemia in macaques.

  2004cited by this paper
• Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase.

  2003cited by this paper
• Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

  2003cited by this paper
• Reticulocyte Response in Sickle Cell Anemia Treated With Recombinant Human Erythropoietin : A Double-Blind Study

  2003cited by this paper
• Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells.

  2003cited by this paper
• Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

  2002cited by this paper
• Faculty Opinions recommendation of HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

  2001cited by this paper
• HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Faculty Opinions recommendation of Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

  2001cited by this paper
• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

  2001cited by this paper
• Inhibition of Collagen Synthesis With Prolyl 4-Hydroxylase Inhibitor Improves Left Ventricular Function and Alters the Pattern of Left Ventricular Dilatation After Myocardial Infarction

  2001cited by this paper
• A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

  2001cited by this paper
• Low oxygen enhances sickle and normal erythropoiesis and fetal hemoglobin synthesis in vitro.

  1995cited by this paper
• Hypoxemia and increased fetal hemoglobin synthesis.

  1994cited by this paper
• The Reactivation of Fetal Hemoglobin Synthesis during Anemia of Prematurity

  1994cited by this paper
• F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study.

  1993cited by this paper
• Fetal hemoglobin in acute and chronic states of erythroid expansion.

  1993cited by this paper
• Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease.

  1993cited by this paper
• Delta beta thalassemia and hereditary persistence of fetal hemoglobin.

  1991cited by this paper
• δβ Thalassemia and Hereditary Persistence of Fetal Hemoglobin

  1991cited by this paper
• Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells.

  1990cited by this paper
• Pharmacokinetics and erythropoietic response to human recombinant erythropoietin in healthy men

  1990cited by this paper
• Proliferation and maturation of human erythroid progenitors in liquid culture.

  1989cited by this paper
• The regulated expression of erythropoietin by two human hepatoma cell lines.

  1987cited by this paper
• Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial.

  1987cited by this paper
• Hematologic evidence of fetal hypoxia among newborn infants at high altitude in Bolivia.

  1986cited by this paper
• Cloning and expression of human erythropoietin cDNA in Escherichia coli.

  1984cited by this paper
• Maternal cigarette smoking and fetal oxygen transport: a study of P50, 2,3-diphosphoglycerate, total hemoglobin, hematocrit, and type F hemoglobin in fetal blood.

  1983cited by this paper
• Maintenance of fetal hemoglobin (HbF) elevations in the baboon by prolonged erythropoietic stress.

  1982cited by this paper
• Genetic Relationship between Fetal Hb Levels in Normal and Erythropoietically Stressed Baboons

  1981cited by this paper
• HEREDITARY PERSISTENCE OF FETAL HAEMOGLOBIN (HPFH) AND δβ THALASSAEMIA

  1979cited by this paper
• Hereditary persistence of fetal haemoglobin (HPFH) and delta beta thalassaemia.

  1979cited by this paper
• Individual variation in the production and survival of F cells in sickle-cell disease.

  1978cited by this paper
• Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia.

  1978cited by this paper
• Oxygen Transport in Congenital Heart Disease: Influence of Fetal Hemoglobin, Red Cell pH, and 2,3-Diphosphoglycerate

  1976cited by this paper
• Oxygen transport of hemoglobin in high-altitude animals (Camelidae).

  1975cited by this paper
• Measurement of fetal hemoglobin in newborn infants; correlation with gestational age and intrauterine hypoxia.

  1957cited by this paper
• MEASUREMENT OF FETAL HEMOGLOBIN IN NEWBORN INFANTS

  1957cited by this paper
• The FASEB Journal • FJ Express Full-Length Article Improved

  year unknowncited by this paper

• Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization

  2026influential citation
• Roxadustat induced fetal hemoglobin in anemic CKD patients: a dual-center real-world observational cohort study.

  2026cites this paper
• Pharmacological HIF-PH Inhibition Suppresses Myoblast Differentiation Through Continued HIF-1α Stabilization

  2025cites this paper
• Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts

  2025influential citation
• Prolyl Hydroxylase Inhibitor-Mediated HIF Activation Drives Transcriptional Reprogramming in Retinal Pigment Epithelium: Relevance to Chronic Kidney Disease

  2025cites this paper
• HIF–Prolyl Hydroxylase Inhibitor Desidustat Increases Pyruvate Kinase Activity and Reduces Oxidative Stress in Red Blood Cells, Causes Erythrocytosis in Thalassaemic Mice, and Reduces Sickling in Sickle Cell Patient's Blood

  2025cites this paper
• Genetic modifications of EGLN1 reactivate HbF production in β0-thalassemia/HbE

  2024cites this paper
• Targeting HIF-1α in sickle cell disease and cancer: unraveling therapeutic opportunities and risks

  2024cites this paper
• The discovery of hemoglobin body: a start to more

  2024cites this paper
• Hypoxia-inducible Factors: Molecular Basis and Clinical Implications

  2023cites this paper
• Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells

  2023influential citation
• Activation of γ-globin expression by hypoxia-inducible factor 1α

  2022cites this paper
• Bone Marrow Macrophages Induce Inflammation by Efferocytosis of Apoptotic Prostate Cancer Cells via HIF-1α Stabilization

  2022cites this paper
• Identification of novel γ-globin inducers among all potential erythroid druggable targets

  2022influential citation
• A narrative review of research advances in hypoxic pulmonary hypertension

  2022cites this paper
• IOX1 fails to reduce α-globin and mediates γ-globin silencing in adult β0-thalassemia/HbE erythroid progenitor cells.

  2022cites this paper
• Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines

  2021cites this paper
• HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review

  2021influential citation
• A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats

  2021cites this paper
• The Participation of the Organism Adaptation Mechanisms to the Lack of Oxygen According to the Assessment of the Fethemoglobin Content in the Peripheral Blood of Patients with Community-acquired Pneumonia

  2021cites this paper
• Uremic Toxins Affect Erythropoiesis during the Course of Chronic Kidney Disease: A Review

  2020cites this paper
• Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate

  2020cites this paper
• Medicina del deporte

  2019cites this paper
• Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified yet Important Action

  2019cites this paper
• Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF- (cid:2) 1 signaling

  2018cites this paper
• Нефрогенная анемия: новые физиологические подходы к терапии на основе имитации гипоксических ответов

  2018cites this paper
• Endurance training prevents negative effects of the hypoxia mimetic dimethyloxalylglycine on cardiac and skeletal muscl e function

  2018influential citation
• Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology

  2018cites this paper
• Metabolic effects of hypoxia and chronic hepatitis C

  2018cites this paper
• Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis

  2018cites this paper
• Hypoxia and HIF-1 activation in bacterial infections.

  2017cites this paper
• Oxygen, Metabolism, and Regeneration: Lessons from Mice.

  2017cites this paper
• The Erythropoietin System Protects the Heart Upon Injury by Cardiac Progenitor Cell Activation.

  2017cites this paper
• High altitude hypoxia as a factor that promotes tibial growth plate development in broiler chickens

  2017cites this paper
• Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer

  2017cites this paper
• The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.

  2017cites this paper
• Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function

  2017cites this paper
• HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

  2016cites this paper
• A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial.

  2016cites this paper
• Preconditioning of Cardiosphere-Derived Cells with Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism

  2016cites this paper
• Prolyl hydroxylase domain enzymes and their role in cell signaling and cancer metabolism.

  2016cites this paper
• MIR193BHG: a novel hypoxia-inducible long noncoding RNA involved in the fine-tuning of cholesterol metabolism

  2016cites this paper
• Erythropoietin in anemia of unknown etiology: A systematic review and meta-analysis

  2016cites this paper
• Endurance training prevents negative effects of the hypoxia mimetic dimethyloxalylglycine on cardiac and skeletal muscle function.

  2016influential citation
• in renal anemia

  2016cites this paper
• Small-molecule inhibitors of HIF-PHD2: a valid strategy to renal anemia treatment in clinical therapy

  2016cites this paper
• Pharmacological targeting of the HIF hydroxylases--A new field in medicine development.

  2016cites this paper
• Hydroxylases regulate intestinal fibrosis through the suppression of ERK mediated TGF-β1 signaling.

  2016cites this paper
• Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia.

  2016cites this paper
• SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders.

  2016cites this paper
• Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected].

  2016cites this paper
• Pharmacological Inhibition of FTO

  2015cites this paper
• A Systems Pharmacology Model of Erythropoiesis in Mice Induced by Small Molecule Inhibitor of Prolyl Hydroxylase Enzymes

  2015cites this paper
• Anaemia in kidney disease: harnessing hypoxia responses for therapy

  2015cites this paper
• Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

  2015cites this paper
• Recent Progress of Prolyl Hydroxylase Domain Inhibitors

  2015cites this paper
• Endurance training prevents negative effects of the hypoxia mimetic dimethyloxalylglycine 1 on cardiac and skeletal muscle function 2 3

  2015influential citation
• Activating mitochondrial function and haemoglobin expression with EH-201, an inducer of erythropoietin in neuronal cells, reverses memory impairment

  2015cites this paper
• The Hypoxia-Inducible Factor Pathway, Prolyl Hydroxylase Domain Protein Inhibitors, and Their Roles in Bone Repair and Regeneration

  2014cites this paper
• Hypoxic Signaling During Tissue Repair and Regenerative Medicine

  2014cites this paper
• Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans.

  2014cites this paper
• HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction

  2014cites this paper
• Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases

  2014influential citation
• Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation.

  2014cites this paper
• Influencia de administración de eritropoyetina humana recombinante en el rendimiento físico: un estudio de revisión

  2014cites this paper
• HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

  2014cites this paper
• Targeting the Hypoxia‐Sensing Pathway in Clinical Hematology

  2014cites this paper
• Ghrelin in ocular pathophysiology: from the anterior to the posterior segment.

  2013cites this paper
• [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues.

  2013cites this paper
• Prolyl 4‐hydroxylases, master regulators of the hypoxia response

  2013cites this paper
• Activation of mitochondrial function and Hb expression in non‐haematopoietic cells by an EPO inducer ameliorates ischaemic diseases in mice

  2013cites this paper
• Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.

  2013cites this paper
• Regulation of erythropoiesis by hypoxia-inducible factors.

  2013cites this paper
• Effect of congenital upregulation of hypoxia inducible factors on percentage of fetal hemoglobin in the blood.

  2013cites this paper
• Renal anemia: from incurable to curable.

  2013cites this paper
• RED CELLS , IRON , AND ERYTHROPOIESIS The effects of the anti-hepcidin Spiegelmer NOX-H 94 on in fl ammation-induced anemia in cynomolgus monkeys

  2013cites this paper
• Nanomaterials for Mirna Delivery and Non-Invasive Imaging in Cardiovascular Regeneration

  2013cites this paper
• Hematopoiesis and the Kidney

  2013cites this paper
• The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.

  2013cites this paper
• proteins Regulation of adult erythropoiesis by prolyl hydroxylase domain

  2013cites this paper
• Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

  2013cites this paper
• Renal CD133(+)/CD73(+) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition.

  2013cites this paper
• Management of Renal Anemia in Children with Chronic Kidney Disease

  2012cites this paper
• Mechanisms and management of retinopathy of prematurity.

  2012cites this paper
• Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

  2012cites this paper
• The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

  2012cites this paper
• Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.

  2012cites this paper
• Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis.

  2012cites this paper
• Expression of fetal hemoglobin in adult humans exposed to high altitude hypoxia.

  2012cites this paper
• The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

  2012cites this paper
• Biomarkers of pituitary neoplasms.

  2012cites this paper
• Biosimilar recombinant human erythropoietins ("epoetins") and future erythropoiesis-stimulating treatments

  2012cites this paper
• Erythropoietin Stimulation and Other Blood Doping Methods

  2012cites this paper
• You can't run from inflammation: lower extremity ischemia, hypoxia signaling, and macrophage subtypes.

  2012cites this paper
• Hematologic Aspects of Kidney Disease

  2012cites this paper
• Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

  2011cites this paper
• Studies on treatment of renal anemia in patients on chronic hemodialysis

  2011cites this paper
• Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.

  2011cites this paper
• HIF1 synergizes with glucocorticoids to promote BFU-E progenitor self-renewal

  2011cites this paper
• Hypoxia-Inducible Factors in Acute Kidney Injury: From Pathophysiology to a Novel Approach of Organ Protection

  2011cites this paper