Role of phospholipase A2s and lipid mediators in secondary damage after spinal cord injury

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cell and Tissue Research

• Publication date

  2012-05-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00441-012-1430-8PMID 22581384
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mammalian phospholipase C.

  2013cited by this paper
• Eotaxin-2 blockade ameliorates experimental autoimmune encephalomyelitis

  2013cited by this paper
• Cannabinoid Type 2 Receptor Activation Downregulates Stroke-Induced Classic and Alternative Brain Macrophage/Microglial Activation Concomitant to Neuroprotection

  2012cited by this paper
• Recent progress in phospholipase A₂ research: from cells to animals to humans.

  2011cited by this paper
• Themed Issue: Cannabinoids in Biology and Medicine, Part I

  2011cited by this paper
• Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation.

  2011cited by this paper
• [Lysophosphatidic acid as initiator of neuropathic pain].

  2011cited by this paper
• RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury.

  2011cited by this paper
• Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution

  2011cited by this paper
• Novel proresolving aspirin-triggered DHA pathway.

  2011cited by this paper
• Phospholipase A2 superfamily members play divergent roles after spinal cord injury

  2011cited by this paper
• Repertoire of microglial and macrophage responses after spinal cord injury

  2011cited by this paper
• Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury

  2011cited by this paper
• Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis

  2011cited by this paper
• Neuroaxonal Dystrophy in Calcium-Independent Phospholipase A2β Deficiency Results from Insufficient Remodeling and Degeneration of Mitochondrial and Presynaptic Membranes

  2011cited by this paper
• Cytosolic Phospholipase A2α Protects against Ischemia/Reperfusion Injury in the Heart

  2011cited by this paper
• Docosahexaenoic Acid Prevents White Matter Damage after Spinal Cord Injury

  2010cited by this paper
• The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury.

  2010cited by this paper
• Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.

  2010cited by this paper
• The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury.

  2010cited by this paper
• The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats.

  2010cited by this paper
• Lipid-mediated cell signaling protects against injury and neurodegeneration.

  2010cited by this paper
• Sterile inflammation: sensing and reacting to damage

  2010cited by this paper
• Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice

  2010influential reference
• Emerging roles of PGE2 receptors in models of neurological disease.

  2010cited by this paper
• Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.

  2010cited by this paper
• DAMPening Inflammation by Modulating TLR Signalling

  2010cited by this paper
• Synthesis of Lipoxin A4 by 5-Lipoxygenase Mediates PPARγ-Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke

  2009cited by this paper
• Cystic fibrosis fatty acid imbalance is linked to ceramide deficiency and corrected by fenretinide.

  2009cited by this paper
• Ibuprofen Enhances Recovery from Spinal Cord Injury by Limiting Tissue Loss and Stimulating Axonal Growth

  2009cited by this paper
• Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

  2009cited by this paper
• Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2‐IIA in mediating oligodendrocyte death

  2009cited by this paper
• Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis.

  2009cited by this paper
• Arachidonyl Trifluoromethyl Ketone Is Neuroprotective after Spinal Cord Injury

  2009cited by this paper
• FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood‐Brain‐Barrier Damage

  2009cited by this paper
• Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.

  2009cited by this paper
• The endocannabinoid system is modulated in response to spinal cord injury in rats.

  2009influential reference
• Defective Generation of a Humoral Immune Response Is Associated with a Reduced Incidence and Severity of Collagen-Induced Arthritis in Microsomal Prostaglandin E Synthase-1 Null Mice1

  2008cited by this paper
• Anti-inflammatory and proresolving lipid mediators.

  2008cited by this paper
• The protective effects of 15‐deoxy‐Δ‐12,14‐prostaglandin J2 in spinal cord injury

  2008influential reference
• The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

  2008cited by this paper
• Pro-inflammatory Secretory Phospholipase A2 Type IIA Binds to Integrins αvβ3 and α4β1 and Induces Proliferation of Monocytic Cells in an Integrin-dependent Manner*

  2008cited by this paper
• Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN)

  2008cited by this paper
• Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury.

  2008cited by this paper
• Fenretinide corrects newly found ceramide deficiency in cystic fibrosis.

  2008cited by this paper
• Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia.

  2008cited by this paper
• Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

  2008cited by this paper
• Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

  2008cited by this paper
• Effects of zileuton and montelukast in mouse experimental spinal cord injury

  2008cited by this paper
• Does COX2-dependent PGE2 play a role in neuropathic pain?

  2008cited by this paper
• Fenretinide prevents the development of osteoporosis in Cftr-KO mice.

  2008cited by this paper
• Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A2 Deficiency in Mice: A Model of Human Neurodegenerative Disease

  2008cited by this paper
• Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.

  2008influential reference
• Biochemistry and physiology of mammalian secreted phospholipases A2.

  2008cited by this paper
• Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes.

  2008cited by this paper
• Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

  2007cited by this paper
• Resolvin E1 and protectin D1 activate inflammation-resolution programmes

  2007cited by this paper
• Focal phospholipases A2 group III injections induce cervical white matter injury and functional deficits with delayed recovery concomitant with Schwann cell remyelination.

  2007cited by this paper
• Divergent effects of prostaglandin receptor signaling on neuronal survival.

  2007cited by this paper
• A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury.

  2007cited by this paper
• Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways.

  2007cited by this paper
• ATP‐induced chemotaxis of microglial processes requires P2Y receptor‐activated initiation of outward potassium currents

  2007cited by this paper
• Nonsteroidal Anti-Inflammatory Drugs Promote Axon Regeneration via RhoA Inhibition

  2007cited by this paper
• Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis.

  2007cited by this paper
• Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved

  2007cited by this paper
• n-3 Polyunsaturated fatty acids and human cytokine synthesis

  2007cited by this paper
• Hematopoietic Prostaglandin D Synthase and DP1 Receptor Are Selectively Upregulated in Microglia and Astrocytes Within Senile Plaques From Human Patients and in a Mouse Model of Alzheimer Disease

  2007cited by this paper
• Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein

  2007cited by this paper
• Emerging roles of DP and CRTH2 in allergic inflammation.

  2006cited by this paper
• Lysophosphatidic acid as the initiator of neuropathic pain.

  2006cited by this paper
• Role of Prostacyclin in the Development of Compression Trauma-Induced Spinal Cord Injury in Rats

  2006cited by this paper
• Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.

  2006cited by this paper
• Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells.

  2006cited by this paper
• Lipoxins and new lipid mediators in the resolution of inflammation.

  2006cited by this paper
• Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage.

  2006cited by this paper
• 1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia.

  2006cited by this paper
• Effects of COX-2 and iNOS Inhibitors Alone or in Combination With Olfactory Ensheathing Cell Grafts After Spinal Cord Injury

  2006cited by this paper
• The phospholipase A2 superfamily and its group numbering system.

  2006cited by this paper
• Modulation of inflammation in brain: a matter of fat

  2006cited by this paper
• A novel role of phospholipase A2 in mediating spinal cord secondary injury

  2006cited by this paper
• 1‐HydroxyPGE1 reduces infarction volume in mouse transient cerebral ischemia

  2006cited by this paper
• Rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 Cause Potent Neuroprotection after Experimental Stroke through Noncompletely Overlapping Mechanisms

  2006cited by this paper
• Omega-3 Fatty Acids Improve Recovery, whereas Omega-6 Fatty Acids Worsen Outcome, after Spinal Cord Injury in the Adult Rat

  2006influential reference
• Mitochondria: More Than Just a Powerhouse

  2006cited by this paper
• Prostaglandin D2-Mediated Microglia/Astrocyte Interaction Enhances Astrogliosis and Demyelination in twitcher

  2006cited by this paper
• The P2Y12 receptor regulates microglial activation by extracellular nucleotides

  2006cited by this paper
• Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity

  2006cited by this paper
• Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice.

  2005cited by this paper
• Prostaglandin EP4 receptor agonist protects against acute neurotoxicity.

  2005cited by this paper
• Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients.

  2005cited by this paper
• Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor

  2005cited by this paper
• Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

  2005cited by this paper
• Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.

  2005cited by this paper
• Localization of cyclooxygenase-2 induced following traumatic spinal cord injury.

  2005cited by this paper
• Involvement of 5-lipoxygenase in spinal cord injury.

  2005cited by this paper
• Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α and interleukin-1β in Wallerian degeneration

  2005cited by this paper
• Phospholipase A2 in astrocytes

  2005cited by this paper
• Deletion of the Prostaglandin E2 EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease

  2005cited by this paper
• Cytosolic phospholipase A2α–deficient mice are resistant to experimental autoimmune encephalomyelitis

  2005cited by this paper
• Protective role for cytosolic phospholipase A2α in autoimmune diabetes of mice

  2005cited by this paper

• Metabolic alterations after traumatic neural injury: Mechanistic insights and potential translational targets for axon regeneration.

  2026cites this paper
• Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease

  2025cites this paper
• Multiomics Integration Reveals a Metabolic Myopathy in Cardiometabolic HFpEF

  2025cites this paper
• Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury

  2024cites this paper
• Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis

  2022cites this paper
• BAPTA, a calcium chelator, neuroprotects injured neurons in vitro and promotes motor recovery after spinal cord transection in vivo

  2021cites this paper
• Biomaterial-supported MSC transplantation enhances cell–cell communication for spinal cord injury

  2021cites this paper
• Biomaterial-supported MSCs transplantation enhances cell-cell communication for spinal cord injury

  2020cites this paper
• Bioactive Lipids in Inflammation After Central Nervous System Injury.

  2019cites this paper
• Moving beyond the glial scar for spinal cord repair

  2019cites this paper
• Cellular and Molecular Mechanisms Involved in Neuroinflammation after Acute Traumatic Spinal Cord Injury

  2019cites this paper
• Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom

  2018cites this paper
• Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

  2017cites this paper
• Cyclin dependent kinase 5: A novel avenue for Alzheimer's disease.

  2017cites this paper
• CNS myelin structural modification induced in vitro by phospholipases A2.

  2016cites this paper
• Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury

  2016cites this paper
• Neuroinflammation: the devil is in the details

  2016cites this paper
• Beneficial effects of IL-37 after spinal cord injury in mice

  2016cites this paper
• Activation of inflammatory resolution programs as a new therapeutic approach to promote neuroprotectin after SCI

  2016influential citation
• Macrophage and microglial plasticity in the injured spinal cord.

  2015influential citation
• Inflammation and Secondary Damage after Spinal Cord Injury

  2015cites this paper
• Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

  2015influential citation
• Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats

  2015cites this paper
• Microglia and Macrophage Responses and Their Role after Spinal Cord Injury

  2015cites this paper
• mitochondrial pathway for biosynthesis of lipid mediators

  2014cites this paper
• Expression and Role of Phospholipase A2 in Central Nervous System Injury and Disease

  2014cites this paper
• (-)-Epigallocatechin-3-gallate (EGCG) modulates neurological function when intravenously infused in acute and, chronically injured spinal cord of adult rats.

  2014cites this paper
• Phospholipase A2 inhibitors for the treatment of inflammatory diseases: a patent review (2010 – present)

  2013cites this paper
• Molecular basis of neural repair mechanisms

  2012cites this paper
• Inflammatory pathways in spinal cord injury.

  2012cites this paper