Rad51 Paralog Complexes BCDX2 and CX3 Act at Different Stages in the BRCA1-BRCA2-Dependent Homologous Recombination Pathway

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular and Cellular Biology

• Publication date

  2012-11-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00465-12PMID 23149936PMCID PMC3554112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of homologous recombination by the PCNA-interacting protein PARI.

  2012cited by this paper
• hSWS1·SWSAP1 Is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair*

  2011influential reference
• Rad51 paralogs Rad55-Rad57 balance the anti-recombinase Srs2 in Rad51 filament formation

  2011cited by this paper
• BRCA1 and BRCA2: different roles in a common pathway of genome protection

  2011cited by this paper
• The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase

  2011cited by this paper
• DNA end resection--unraveling the tail.

  2011cited by this paper
• Ring-shaped Rad51 Paralog Protein Complexes Bind Holliday Junctions and Replication Forks as Visualized by Electron Microscopy*

  2010cited by this paper
• Regulation of homologous recombination in eukaryotes.

  2010cited by this paper
• Regulation of DNA strand exchange in homologous recombination.

  2010cited by this paper
• Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis.

  2010influential reference
• GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.

  2010cited by this paper
• Rad52 inactivation is synthetically lethal with BRCA2 deficiency

  2010influential reference
• XRCC2 and XRCC3 Regulate the Balance between Short- and Long-Tract Gene Conversions between Sister Chromatids

  2009cited by this paper
• The yeast Shu complex couples error‐free post‐replication repair to homologous recombination

  2009cited by this paper
• RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation

  2009cited by this paper
• RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.

  2007cited by this paper
• Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3.

  2007cited by this paper
• Role of RAD51C and XRCC3 in Genetic Recombination and DNA Repair*

  2007cited by this paper
• Sws1 is a conserved regulator of homologous recombination in eukaryotic cells

  2006cited by this paper
• Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage

  2005cited by this paper
• A Genetic Screen for top3 Suppressors in Saccharomyces cerevisiae Identifies SHU1, SHU2, PSY3 and CSM2

  2005cited by this paper
• RAD51C Is Required for Holliday Junction Processing in Mammalian Cells

  2004cited by this paper
• XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells

  2004cited by this paper
• Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

  2004cited by this paper
• Human Rad51C Deficiency Destabilizes XRCC3, Impairs Recombination, and Radiosensitizes S/G2-phase Cells*

  2004cited by this paper
• Rad51 Recombinase and Recombination Mediators*

  2003cited by this paper
• Recombinational DNA repair and human disease.

  2002cited by this paper
• Homologous Pairing and Ring and Filament Structure Formation Activities of the Human Xrcc2·Rad51D Complex*

  2002cited by this paper
• XRCC3 controls the fidelity of homologous recombination: roles for XRCC3 in late stages of recombination.

  2002cited by this paper
• Homologous-pairing activity of the human DNA-repair proteins Xrcc3⋅Rad51C

  2001cited by this paper
• Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

  2001cited by this paper
• Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.

  2001cited by this paper
• Identification and purification of two distinct complexes containing the five RAD51 paralogs.

  2001influential reference
• The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair

  2000cited by this paper
• Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice

  2000cited by this paper
• Midgestation lethality in mice deficient for the RecA‐related gene, Rad51d/Rad51l3

  2000cited by this paper
• Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53−/− Background

  1999cited by this paper
• XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.

  1999cited by this paper
• A surfeit of RAD51-like genes?

  1999cited by this paper
• A Chinese hamster ovary cell line hypersensitive to ionizing radiation and deficient in repair replication.

  1988cited by this paper
• Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells.

  1987cited by this paper
• Mutants of the Five Rad51 Paralogs Recombinational Repair in Knockout Chromosome Instability and Defective

  year unknowncited by this paper

• SFPQ promotes homologous recombination via mRNA stabilization of RAD51 and its paralogs.

  2026cites this paper
• Dss1 facilitates Rad51 recruitment downstream of BRCA2/Brh2 in response to DNA damage.

  2026cites this paper
• SFPQ Promotes Homologous Recombination via mRNA Stabilization of RAD51 and Its Paralogs

  2025cites this paper
• GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1

  2025cites this paper
• Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review)

  2025cites this paper
• Biochemical Mechanisms of Genetic Recombination and DNA Repair

  2025cites this paper
• Inactivation of a protein hydroxylase complex impairs replication fork restart in cancer and neurodevelopmental disorders

  2025cites this paper
• The Impact of Uncommon HRR Alterations as Predictors of Efficacy of PARP Inhibitors in Metastatic Castration-Resistant Prostate Cancer: A Meta-Analysis of Randomized Controlled Trials

  2025cites this paper
• Homologous recombination deficiency in endometrial cancer: shedding light on recent clinical findings.

  2025cites this paper
• Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA

  2024cites this paper
• What About the Others? Clinical Management of Gynecologic Cancer Risk in Patients With Moderate-Risk Hereditary Cancer Genes (ATM, BRIP1, RAD51C, RAD51D, and PALB2)

  2024cites this paper
• Host repair polymorphisms and H. pylori genes in gastric disease outcomes: Who are the guardian and villains?

  2024cites this paper
• PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells

  2024cites this paper
• RAD51 Paralogs and RAD51 Paralog Complexes BCDX2 and CX3 Interact with BRCA2

  2024cites this paper
• Association between rheumatoid arthritis and risk of radiotherapy toxicity: a systematic review

  2024cites this paper
• RAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis

  2024cites this paper
• Synthetic lethal strategies for the development of cancer therapeutics

  2024cites this paper
• SNV/indel hypermutator phenotype in biallelic RAD51C variant: Fanconi anemia

  2023cites this paper
• RAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis

  2023cites this paper
• Identification of small molecule inhibitors of RAD52 for breast cancer therapy: in silico approach

  2023cites this paper
• Hot on RAD51C: structure and functions of RAD51C‐XRCC3

  2023cites this paper
• A cytological revisit on parthenogenetic Artemia and the deficiency of a meiosis-specific recombinase DMC1 in the possible transition from bisexuality to parthenogenesis

  2023cites this paper
• SNV/indel hypermutator phenotype in biallelic RAD51C variant - Fanconi anemia

  2023cites this paper
• Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers

  2023cites this paper
• Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

  2023cites this paper
• RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles

  2023cites this paper
• Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.

  2023cites this paper
• RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases

  2023cites this paper
• C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair.

  2023cites this paper
• Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C

  2023cites this paper
• A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content

  2023cites this paper
• Finding significance: New perspectives in variant classification of the RAD51 regulators, BRCA2 and beyond.

  2023cites this paper
• Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

  2022cites this paper
• Particulate hexavalent chromium inhibits homologous recombination repair by targeting RAD51 paralogs in human lung fibroblasts.

  2022influential citation
• An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases

  2022cites this paper
• RADA-dependent branch migration has a predominant role in plant mitochondria and its defect leads to mtDNA instability and cell cycle arrest

  2022cites this paper
• A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.

  2022cites this paper
• Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

  2022cites this paper
• C1orf112 is a novel regulator of interstrand crosslink that decreases FIGNL1-RAD51 interaction

  2022cites this paper
• Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways

  2022cites this paper
• Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification.

  2022cites this paper
• Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

  2022cites this paper
• DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells

  2022cites this paper
• Medulloblastoma and the DNA Damage Response

  2022cites this paper
• BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA

  2022cites this paper
• Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability

  2022influential citation
• The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population

  2022cites this paper
• New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response

  2021cites this paper
• Sexual Dimorphism in Mouse Meiosis

  2021cites this paper
• Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas

  2021cites this paper
• Identification of a RAD52 Inhibitor Inducing Synthetic Lethality in BRCA2-Deficient Cancer Cells

  2021cites this paper
• The RAD51D c.82G>A (p.Val28Met) variant disrupts normal splicing and is associated with hereditary ovarian cancer

  2021cites this paper
• RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy

  2021cites this paper
• Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?

  2021cites this paper
• Retroperitoneal leiomyosarcoma in a female patient with a germline splicing variant RAD51D c.904-2A > T: a case report

  2021cites this paper
• RAD52: Paradigm of Synthetic Lethality and New Developments

  2021cites this paper
• RNA-seq of the medusavirus suggests remodeling of the host nuclear environment at an early infection stage

  2021cites this paper
• Germline mutations in RAD51C and RAD51D and hereditary predisposition to ovarian cancer.

  2021cites this paper
• XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase

  2021cites this paper
• Crosstalk between CST and RPA regulates RAD51 activity during replication stress

  2021cites this paper
• Replication Protein A Phosphorylation Facilitates RAD52-Dependent Homologous Recombination in BRCA-Deficient Cells

  2021cites this paper
• A decade of RAD51C and RAD51D germline variants in cancer

  2021cites this paper
• TAZ maintains telomere length in TNBC cells by mediating Rad51C expression

  2021cites this paper
• Single-Molecule Tethered Particle Motion Studies on the DNA Recombinase Filament Assembly and Disassembly.

  2021cites this paper
• Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination

  2021cites this paper
• Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination

  2021cites this paper
• Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.

  2021cites this paper
• CdSe/ZnS quantum dots induced spermatogenesis dysfunction via autophagy activation.

  2020cites this paper
• It’s complex : studies on the genetics of canine hip dysplasia

  2020cites this paper
• A fork in the road: Where homologous recombination and stalled replication fork protection part ways

  2020cites this paper
• XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition

  2020cites this paper
• Epidemiology and Genetic Susceptibility of Breast and Ovarian Cancer in Sardinian Population

  2020cites this paper
• Pan-cancer landscape of homologous recombination deficiency

  2020cites this paper
• The RAD52 S346X variant reduces risk of developing breast cancer in carriers of pathogenic germline BRCA2 mutations

  2020cites this paper
• Homologous DNA Pairing and Strand Exchange

  2020influential citation
• Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana

  2020cites this paper
• Physiological and Pathological Roles of RAD52 at DNA Replication Forks

  2020cites this paper
• Next generation sequencing of cervical high grade dysplasia and invasive squamous cell carcinoma: A case study.

  2020cites this paper
• Next generation sequencing analysis of BRCA1 and BRCA2 identifies novel variations in breast cancer.

  2020cites this paper
• Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

  2020cites this paper
• mutants are affected in the stability of the mitochondrial genome

  2020cites this paper
• RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status

  2020cites this paper
• BRG1 Activates Proliferation and Transcription of Cell Cycle-Dependent Genes in Breast Cancer Cells

  2020cites this paper
• Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

  2020influential citation
• Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test?

  2020cites this paper
• OsRAD51D promotes homologous pairing and recombination by preventing non-homologous interactions in rice meiosis.

  2020cites this paper
• DNA Double Strand Break Repair - Related Synthetic Lethality.

  2019cites this paper
• Structural basis of homologous recombination

  2019cites this paper
• Emerging Roles of RAD52 in Genome Maintenance

  2019cites this paper
• Regulation of resection by chromatin associated proteins

  2019cites this paper
• Novel protective and risk loci in hip dysplasia in German Shepherds

  2019cites this paper
• Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers.

  2019cites this paper
• Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells

  2019influential citation
• ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response.

  2019cites this paper
• XRCC2 (X-ray repair cross complementing 2)

  2019cites this paper
• PARP Trapping Beyond Homologous Recombination and Platinum Sensitivity in Cancers

  2019influential citation
• FUNCTIONAL INSIGHTS INTO RAD51 REGULATORY PROTEINS IN HOMOLOGOUS RECOMBINATION

  2019influential citation
• PARP1 Co-Regulates EP300–BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair

  2019cites this paper
• RADA is a main branch migration factor in plant mitochondrial recombination and its defect leads to mtDNA instability and cell cycle arrest

  2019cites this paper
• RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies

  2019cites this paper