The critical role of glutathione in maintenance of the mitochondrial genome.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Free Radical Biology & Medicine

• Publication date

  2010-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.freeradbiomed.2010.09.023PMID 20888410
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione.

  2010cited by this paper
• The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation.

  2009cited by this paper
• Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae

  2009cited by this paper
• Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae.

  2009cited by this paper
• The Interaction of Mitochondrial Iron with Manganese Superoxide Dismutase*

  2009cited by this paper
• Real-time imaging of the intracellular glutathione redox potential

  2008cited by this paper
• Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid.

  2008cited by this paper
• Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe–2S] clusters

  2008cited by this paper
• The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix*

  2008cited by this paper
• Confocal imaging of glutathione redox potential in living plant cells

  2008cited by this paper
• Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.

  2007cited by this paper
• CGFS-type monothiol glutaredoxins from the cyanobacterium Synechocystis PCC6803 and other evolutionary distant model organisms possess a glutathione-ligated [2Fe-2S] cluster.

  2007cited by this paper
• A suite of Gateway® cloning vectors for high‐throughput genetic analysis in Saccharomyces cerevisiae

  2007cited by this paper
• Role of Glutaredoxin-3 and Glutaredoxin-4 in the Iron Regulation of the Aft1 Transcriptional Activator in Saccharomyces cerevisiae*

  2006cited by this paper
• Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

  2006cited by this paper
• Mitochondrial glutathione transport: physiological, pathological and toxicological implications.

  2006cited by this paper
• The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2

  2006cited by this paper
• Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae

  2006cited by this paper
• Alcohol and oxidative liver injury

  2006cited by this paper
• Hepatic mitochondrial glutathione: transport and role in disease and toxicity.

  2005cited by this paper
• Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia.

  2005cited by this paper
• A disulfide relay system in the intermembrane space of mitochondria that mediates protein import.

  2005cited by this paper
• Oxidative and nitrosative stress in brain mitochondria of diabetic rats.

  2005cited by this paper
• Direct Activation of Genes Involved in Intracellular Iron Use by the Yeast Iron-Responsive Transcription Factor Aft2 without Its Paralog Aft1

  2005cited by this paper
• Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae.

  2004cited by this paper
• Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators*

  2004cited by this paper
• Glutathione, altruistic metabolite in fungi.

  2004cited by this paper
• Nuclear Monothiol Glutaredoxins of Saccharomyces cerevisiae Can Function as Mitochondrial Glutaredoxins*

  2004cited by this paper
• Alternative Start Sites in the Saccharomyces cerevisiae GLR1 Gene Are Responsible for Mitochondrial and Cytosolic Isoforms of Glutathione Reductase*

  2004cited by this paper
• Diabetes and mitochondrial oxidative stress: A study using heart mitochondria from the diabetic Goto-Kakizaki rat

  2003cited by this paper
• Coupling of the Transcriptional Regulation of Glutathione Biosynthesis to the Availability of Glutathione and Methionine via the Met4 and Yap1 Transcription Factors*

  2003cited by this paper
• Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae.

  2003cited by this paper
• Aft1p and Aft2p Mediate Iron-responsive Gene Expression in Yeast through Related Promoter Elements*

  2003cited by this paper
• Subcellular Localization of Aft1 Transcription Factor Responds to Iron Status in Saccharomyces cerevisiae *

  2002cited by this paper
• Maturation of Cytosolic Iron-Sulfur Proteins Requires Glutathione*

  2002cited by this paper
• The essential and ancillary role of glutathione in Saccharomyces cerevisiae analysed using a grande gsh1 disruptant strain.

  2001cited by this paper
• Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.

  2001cited by this paper
• A Genetic Investigation of the Essential Role of Glutathione

  2001cited by this paper
• Glutathione depletion leads to delayed growth stasis in Saccharomyces cerevisiae : evidence of a partially overlapping role for thioredoxin

  2000cited by this paper
• Maintenance and Integrity of the Mitochondrial Genome: a Plethora of Nuclear Genes in the Budding Yeast

  2000cited by this paper
• Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and saccharomyces cerevisiae responses to oxidative stress.

  2000cited by this paper
• Blood glutathione decreases in chronic diseases.

  2000cited by this paper
• Grx5 Glutaredoxin Plays a Central Role in Protection against Protein Oxidative Damage inSaccharomyces cerevisiae

  1999cited by this paper
• Oxygen Stress: A Regulator of Apoptosis in Yeast

  1999cited by this paper
• Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes.

  1998cited by this paper
• Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae.

  1998cited by this paper
• Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine.

  1997cited by this paper
• Glutathione is an essential metabolite required for resistance to oxidative stress in the yeastSaccharomyces cerevisiae

  1996cited by this paper
• Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat.

  1996cited by this paper
• Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

  1994cited by this paper
• Oxidative damage in neurodegenerative disease.

  1994cited by this paper
• A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol

  1994cited by this paper
• Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

  1994cited by this paper
• Systemic deficiency of glutathione in cystic fibrosis.

  1993cited by this paper
• Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease.

  1992cited by this paper
• Glutathione deficiency leads to mitochondrial damage in brain.

  1991cited by this paper
• Molecular cloning of the gamma-glutamylcysteine synthetase gene of Saccharomyces cerevisiae.

  1991cited by this paper
• Molecular cloning of the γ‐glutamylcysteine synthetase gene of Saccharomyces cerevisiae

  1991cited by this paper
• High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.

  1990cited by this paper
• Isolation and Characterization of Glutathione Biosynthesis-deficient Mutants in Saccharomyces cerevisiae

  1990cited by this paper
• Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

  1989cited by this paper
• Systemic glutathione deficiency in symptom-free HIV-seropositive individuals.

  1989cited by this paper
• Biogenesis of mitochondria.

  1988cited by this paper
• Glutathione metabolism as a determinant of therapeutic efficacy: a review.

  1984cited by this paper
• Glutathione.

  1983cited by this paper
• Construction and use of gene fusions to lacZ (beta-galactosidase) that are expressed in yeast.

  1983cited by this paper
• [9] Construction and use of gene fusions to lacZ (β-galactosidase) that are expressed in yeast

  1983cited by this paper
• Transport and metabolism of glutathione and gamma-glutamyl amino acids.

  1983cited by this paper
• Visualization of yeast mitochondrial DNA with the fluorescent stain "DAPI".

  1979cited by this paper
• The biogenesis of mitochondria.

  1970cited by this paper

• Cysteine import via the high-affinity GSH transporter Hgt1 rescues GSH auxotrophy in yeast

  2024cites this paper
• Effects of glutathione on mitochondrial DNA and antioxidant enzyme activities in Drosophila melanogaster

  2022cites this paper
• The role of mitochondrial reactive oxygen species in insulin resistance.

  2021cites this paper
• Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control

  2021cites this paper
• Methylglyoxal-Scavenging Enzyme Activities Trigger Erythroascorbate Peroxidase and Cytochrome c Peroxidase in Glutathione-Depleted Candida albicans

  2020cites this paper
• In Vivo Imaging with Genetically Encoded Redox Biosensors

  2020cites this paper
• Stress and ageing in yeast.

  2019cites this paper
• Glutathione redox state plays a key role in flower development and pollen vigour

  2019cites this paper
• Low Ctr1p, due to lack of Sco1p results in lowered cisplatin uptake and mediates insensitivity of rho0 yeast to cisplatin.

  2018cites this paper
• Endoplasmic reticulum (ER) stress–induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant

  2018cites this paper
• Inducible NAD(H)-linked methylglyoxal oxidoreductase regulates cellular methylglyoxal and pyruvate through enhanced activities of alcohol dehydrogenase and methylglyoxal-oxidizing enzymes in glutathione-depleted Candida albicans.

  2018cites this paper
• Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation

  2017cites this paper
• Mitochondrial Glutathione: Regulation and Functions

  2017cites this paper
• Predictive value of selected biomarkers related to metabolism and oxidative stress in children with autism spectrum disorder

  2017cites this paper
• Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system

  2016cites this paper
• Quantification of oxidative stress biomarkers: development of a method by ultra performance liquid chromatography

  2016cites this paper
• Dissecting Redox Biology Using Fluorescent Protein Sensors

  2016cites this paper
• Disruption of steroidogenesis after dimethoate exposure and efficacy of N-acetylcysteine in rats: an old drug with new approaches

  2016cites this paper
• Newly identified protein Imi1 affects mitochondrial integrity and glutathione homeostasis in Saccharomyces cerevisiae.

  2015cites this paper
• Combined effect of cadmium, lead, and UV rays on Bacillus cereus using comet assay and oxidative stress parameters

  2015cites this paper
• Mecanismes implicats en la senyalització i la defensa front l'estrès per selenit en Saccharomyces cerevisiae

  2014cites this paper
• The role of mitochondrial biogenesis and ROS in the control of energy supply in proliferating cells.

  2014cites this paper
• Glutathione is essential to preserve nuclear function and cell survival under oxidative stress.

  2014cites this paper
• Glutathione Deficiency Leads to Riboflavin Oversynthesis in the Yeast Pichia guilliermondii

  2014cites this paper
• Mitochondrial function and mitochondrial DNA maintenance with advancing age

  2014cites this paper
• Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition

  2014cites this paper
• Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae.

  2014cites this paper
• Featured Article: Inhibition of glutathione synthesis distinctly alters mitochondrial and cytosolic redox poise

  2014cites this paper
• Excitotoxicity and oxidative damages induced by methylmercury in rat cerebral cortex and the protective effects of tea polyphenols

  2014cites this paper
• Functions and Cellular Compartmentation of the Thioredoxin and Glutathione Pathways in Yeast

  2013cites this paper
• Protective Effect of Myricetin on Proteins and Lipids of Erythrocytes Membranes

  2013cites this paper
• Distinct Redox Regulation in Sub-Cellular Compartments in Response to Various Stress Conditions in Saccharomyces cerevisiae

  2013influential citation
• The AMPK Family Member Snf1 Protects Saccharomyces cerevisiae Cells upon Glutathione Oxidation

  2013cites this paper
• Toxicity of CuO nanoparticles to yeast Saccharomyces cerevisiae BY4741 wild-type and its nine isogenic single-gene deletion mutants.

  2013cites this paper
• High resolution imaging of subcellular glutathione concentrations by quantitative immunoelectron microscopy in different leaf areas of Arabidopsis

  2013cites this paper
• Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria.

  2013cites this paper
• Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?

  2013cites this paper
• A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of subcellular redox homeostasis

  2012influential citation
• Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes.

  2012influential citation
• Glutathione Metabolism and Its Contribution to Antiapoptotic Properties of α-Crystallins in the Retina

  2012cites this paper
• Glutathione: Physiological and Clinical Relevance

  2012cites this paper
• Aging Research in Yeast

  2012influential citation
• Oxidative stresses and ageing.

  2012cites this paper
• Changes in mitochondrial glutathione levels and protein thiol oxidation in ∆yfh1 yeast cells and the lymphoblasts of patients with Friedreich's ataxia.

  2012cites this paper
• Brain Region-Specific Glutathione Redox Imbalance in Autism

  2012cites this paper
• cAMP-induced Mitochondrial Compartment Biogenesis

  2012cites this paper
• Oxidative Stress Induced S-glutathionylation and Proteolytic Degradation of Mitochondrial Thymidine Kinase 2*

  2012cites this paper
• A Genome-Wide Screen in Yeast Identifies Specific Oxidative Stress Genes Required for the Maintenance of Sub-Cellular Redox Homeostasis

  2012influential citation
• Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats.

  2011cites this paper
• Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol‐redox control

  2011cites this paper
• Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms

  2011cites this paper
• Subcellular distribution of glutathione and its dynamic changes under oxidative stress in the yeast Saccharomyces cerevisiae

  2011influential citation