Mitochondrial function and mitochondrial DNA maintenance with advancing age

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Biogerontology (Dordrecht)

• Publication date

  2014-07-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10522-014-9515-2PMID 25015781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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• Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation.

  2014cited by this paper
• Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

  2014influential reference
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Mitochondrial Fusion Proteins and Human Diseases

  2013influential reference
• The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's disease.

  2013cited by this paper
• Regulation of mitochondrial biogenesis and PGC-1α under cellular stress.

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion.

  2013cited by this paper
• Pathways for Maintenance of Mitochondrial DNA Integrity and Mitochondrial Functions in Cells Exposed to Ionizing Radiation

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  2013cited by this paper
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  2013cited by this paper
• [Pathways for maintenance of mitochondrial DNA integrity and mitochondrial functions in cells exposed to ionizing radiation].

  2013cited by this paper
• Proteolytic control of mitochondrial function and morphogenesis.

  2013cited by this paper
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  2013cited by this paper
• The retrograde response: when mitochondrial quality control is not enough.

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target

  2013cited by this paper
• The role of mitochondria in aging.

  2013influential reference
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  2013cited by this paper
• mTOR is a key modulator of ageing and age-related disease

  2013influential reference
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  2013cited by this paper
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  2013cited by this paper
• New insights into the function and regulation of mitochondrial fission.

  2013cited by this paper
• Quality control of mitochondria during aging: Is there a good and a bad side of mitochondrial dynamics?

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  2013cited by this paper
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• Integrated pathways of parkin control over mitochondrial maintenance - relevance to Parkinson's disease pathogenesis.

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• Replicating animal mitochondrial DNA

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  2013cited by this paper
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  2012influential reference
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  2012influential reference
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  2012cited by this paper
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  2017cites this paper
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