miR-149 in Human Cancer: A Systemic Review

Yun-jie He,Dan-dan Yu,Ling-ping Zhu,Shanliang Zhong,Jian-hua Zhao,Jin-hai Tang

Published 2018 in Journal of Cancer

ABSTRACT

MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers and expect to lay the foundation for future works on this important microRNA.

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