The recent discovery linking narcolepsy, a sleep disorder characterized by very short REM sleep latency, with a neuropeptide that regulates feeding and energy metabolism, provides a way to understand how several behaviors may be disrupted as a result of a defect in this peptide. In this chapter we review the evidence linking hypocretin and sleep, including our own studies, and propose that a defect in the lateral hypothalamus that also involves the hypocretin neurons is likely to produce a disturbance in sleep, mood, appetite, and rhythms.
Hypothalamic Regulation of Sleep
R. Salín-Pascual,D. Gerashchenko,M. Greco,C. Blanco-Centurion,P. Shiromani
Published 2001 in Neuropsychopharmacology
ABSTRACT
PUBLICATION RECORD
- Publication year
2001
- Venue
Neuropsychopharmacology
- Publication date
2001-11-01
- Fields of study
Biology, Medicine, Psychology
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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