Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels.

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• Publication year

  1998

• Venue

  FEBS Letters

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 9845331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation

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• Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity.

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• Identification of Structural Elements of a Scorpion α-Neurotoxin Important for Receptor Site Recognition*

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  1990cited by this paper
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  1988cited by this paper
• Molecular properties of voltage-sensitive sodium channels.

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  1984cited by this paper
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  1978cited by this paper
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  1977cited by this paper
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  2018cites this paper
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  2016cites this paper
• [Relationships between venomous function and innate immune function].

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