Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Clinical Cancer Research

• Publication date

  2014-11-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-14-0809PMID 25388163PMCID PMC4333206
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Phase Ib Dose Escalation Trial of RO4929097 (a γ-secretase inhibitor) in Combination with Exemestane in Patients with ER + Metastatic Breast Cancer (MBC).

  2021cited by this paper
• Targeting notch signaling pathway in cancer: clinical development advances and challenges.

  2014cited by this paper
• Disclosure of Potential Conflicts of Interest

  2014cited by this paper
• From fly wings to targeted cancer therapies: a centennial for notch signaling.

  2014influential reference
• The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells

  2014cited by this paper
• Therapeutic modulation of Notch signalling — are we there yet?

  2014cited by this paper
• Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells

  2013cited by this paper
• Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis

  2013cited by this paper
• Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer.

  2013cited by this paper
• Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.

  2013cited by this paper
• Combining Notch inhibition with current therapies for breast cancer treatment

  2013cited by this paper
• Notch inhibitors for cancer treatment.

  2013cited by this paper
• Synergistic Effect of the γ‐Secretase Inhibitor PF‐03084014 and Docetaxel in Breast Cancer Models

  2013cited by this paper
• Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

  2013cited by this paper
• Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells

  2013cited by this paper
• Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.

  2012cited by this paper
• ALDH+ tumor‐initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ‐secretase inhibitor and irinotecan in colorectal cancer

  2012cited by this paper
• A phase II study of RO4929097 in metastatic colorectal cancer.

  2012cited by this paper
• The double-edged sword of Notch signaling in cancer.

  2012cited by this paper
• Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models

  2012cited by this paper
• S1-5: Modulation of Cancer and Stem Cell Biomarkers by the Notch Inhibitor MK-0752 Added to Endocrine Therapy for Early Stage ER+ Breast Cancer.

  2011cited by this paper
• Biological roles of the Delta family Notch ligand Dll4 in tumor and endothelial cells in ovarian cancer.

  2011cited by this paper
• Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells.

  2011cited by this paper
• Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

  2011cited by this paper
• MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme

  2011cited by this paper
• Vascular balancing act: EGFL7 and Notch.

  2010cited by this paper
• Targeting Notch signaling pathway to overcome drug resistance for cancer therapy.

  2010cited by this paper
• Therapeutic antibody targeting of individual Notch receptors

  2010cited by this paper
• Notch signaling: emerging molecular targets for cancer therapy.

  2010cited by this paper
• Direct inhibition of the NOTCH transcription factor complex

  2010cited by this paper
• Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

  2010cited by this paper
• Direct inhibition of the NOTCH transcription factor complex

  2009cited by this paper
• MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

  2009cited by this paper
• gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity.

  2009cited by this paper
• Down‐regulation of the Notch pathway mediated by a γ‐secretase inhibitor induces anti‐tumour effects in mouse models of T‐cell leukaemia

  2009influential reference
• Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.

  2009cited by this paper
• Notch1 is an effector of Akt and hypoxia in melanoma development.

  2008cited by this paper
• Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3*

  2008cited by this paper
• A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis.

  2008cited by this paper
• Notch signaling regulates tumor angiogenesis by diverse mechanisms

  2008cited by this paper
• Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.

  2008cited by this paper
• Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy.

  2008cited by this paper
• Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

  2007cited by this paper
• The multifaceted role of Notch in cancer.

  2007cited by this paper
• Structural basis for autoinhibition of Notch

  2007cited by this paper
• Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

  2006cited by this paper
• Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

  2006cited by this paper
• Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression.

  2006cited by this paper
• Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes

  2006cited by this paper
• Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

  2006cited by this paper
• Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.

  2006cited by this paper
• Target Selectivity of Vertebrate Notch Proteins

  2006cited by this paper
• Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

  2006cited by this paper
• Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

  2006cited by this paper
• Recent insights into the role of Notch signaling in tumorigenesis.

  2006cited by this paper
• Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.

  2005cited by this paper
• High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival.

  2005cited by this paper
• Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

  2004cited by this paper
• Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

  2004cited by this paper
• JAGGED1 Expression Is Associated with Prostate Cancer Metastasis and Recurrence

  2004cited by this paper
• Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation*

  2004cited by this paper
• Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling

  2003cited by this paper
• Glycosylation regulates Notch signalling

  2003cited by this paper
• Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways

  2003influential reference
• Notch1 functions as a tumor suppressor in mouse skin

  2003cited by this paper
• Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

  2002cited by this paper
• Regulation of notch signaling by o-linked fucose.

  2002cited by this paper
• Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

  2001cited by this paper
• Soluble Jagged 1 Represses the Function of Its Transmembrane Form to Induce the Formation of the Src-dependent Chord-like Phenotype*

  2001cited by this paper
• Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling.

  2000cited by this paper
• A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.

  2000cited by this paper
• A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.

  2000cited by this paper
• The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.

  1999cited by this paper
• A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

  1999cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998cited by this paper
• Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region.

  1998cited by this paper
• The Notch1 receptor is cleaved constitutively by a furin-like convertase.

  1998cited by this paper
• Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.

  1997cited by this paper
• Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.

  1991cited by this paper
• The Analysis of a Case of Continuous Variation in Drosophila by a Study of Its Linkage Relations

  1914cited by this paper

• Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Malignancies by Targeting the γ-Secretase Complex: A Systematic Review

  2026cites this paper
• Notch1+ cervical cancer cells may promote perineural invasion by secreting neurotrophin-4

  2026cites this paper
• The Critical Role of Epithelial-Mesenchymal Transition (EMT) in Colorectal Cancer Progression and Therapeutic Outcomes.

  2026cites this paper
• Molecular and Clinicopathological Biomarkers Predicting Brain Metastasis in Triple-Negative Breast Cancer: A Systematic Review.

  2026cites this paper
• Natural bioactive compounds as notch signaling modulators: cutting-edge strategies for cancer therapy

  2025cites this paper
• Therapeutic and Prognostic Relevance of Cancer Stem Cell Populations in Endometrial Cancer: A Narrative Review

  2025cites this paper
• Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5

  2025cites this paper
• Auranofin Synergizes with Cisplatin in Reducing Tumor Burden of NOTCH-Dependent Ovarian Cancer

  2025cites this paper
• Molecular Alterations and Pathways in Intrahepatic Cholangiocarcinoma: Available Evidence and New Perspectives

  2025cites this paper
• Current research of the Notch pathway in hepatocellular carcinoma

  2025cites this paper
• Functional Roles and Mechanistic Insights of YEATS Domain Proteins in Digestive System Tumors

  2025cites this paper
• LINC01410 in cancer: a comprehensive review of its oncogenic role, regulatory mechanisms, and clinical implications

  2025cites this paper
• Research on the signaling pathway and the related mechanism of traditional Chinese medicine intervention in chronic gastritis of the “inflammation-cancer transformation”

  2024cites this paper
• Harnessing the role of aberrant cell signaling pathways in glioblastoma multiforme: a prospect towards the targeted therapy

  2024cites this paper
• Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML

  2024cites this paper
• Application of hydrogels for targeting cancer stem cells in cancer treatment.

  2024cites this paper
• Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

  2024cites this paper
• The Prediction of DLL4 as a Prognostic Biomarker in Patients with Gastric Cancer Using Anti-DLL4 Nanobody

  2024cites this paper
• Notch‐Targeted Therapeutic in Colorectal Cancer by Notch1 Attenuation Via Tumor Microenvironment‐Responsive Cascade DNA Delivery

  2024cites this paper
• RAB4A is a master regulator of cancer cell stemness upstream of NUMB–NOTCH signaling

  2024cites this paper
• Modulation of Notch signaling pathway in activated hepatic stellate cells does not ameliorate the outcome of liver fibrosis in carbon tetrachloride and DDC-feeding models

  2024cites this paper
• Notch Signaling and PD-1/PD-L1 Interaction in Hepatocellular Carcinoma: Potentialities of Combined Therapies

  2024cites this paper
• Notch signaling in digestive system cancers: Roles and therapeutic prospects.

  2024cites this paper
• A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer

  2023cites this paper
• Comprehensive bioinformatic analysis of mind bomb 1 gene in stomach adenocarcinoma

  2023cites this paper
• The Notch signaling pathway in desmoid tumor: Recent advances and the therapeutic prospects.

  2023cites this paper
• Analysing potent biomarkers along phytochemicals for breast cancer therapy: an in silico approach

  2023cites this paper
• Cannabinoid Combination Targets NOTCH1-Mutated T-ALL Through the Integrated Stress Response Pathway

  2023cites this paper
• Notch signaling pathway: a new target for neuropathic pain therapy

  2023cites this paper
• Cancer Stem Cells in Colorectal Cancer: Implications for Targeted Immunotherapies

  2023cites this paper
• Self-Renewal and Pluripotency in Osteosarcoma Stem Cells’ Chemoresistance: Notch, Hedgehog, and Wnt/β-Catenin Interplay with Embryonic Markers

  2023cites this paper
• The Intricate Notch Signaling Dynamics in Therapeutic Realms of Cancer.

  2023cites this paper
• γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway

  2023cites this paper
• NOTCH Signaling in Osteosarcoma

  2023cites this paper
• Cancer Stem Cells: Recent Insights and Therapies.

  2023cites this paper
• Cancer stem cells in colorectal cancer: signaling pathways involved in stemness and therapy resistance.

  2023cites this paper
• Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy

  2022cites this paper
• Modulation of Notch Signaling Pathway by Bioactive Dietary Agents

  2022influential citation
• Inhibition of GSK3β Promotes Proliferation and Suppresses Apoptosis of Porcine Muscle Satellite Cells

  2022cites this paper
• Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer

  2022cites this paper
• Curcumin-Coated Poly(lactic-co-glycolic acid) Nanoparticles Affect Colorectal Cancer Cells Growth by Regulating Notch Signaling Pathway

  2022cites this paper
• Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

  2022cites this paper
• Analyzing the Interaction of RBPJ with Mitotic Chromatin and Its Impact on Transcription Reactivation upon Mitotic Exit.

  2022cites this paper
• Development of anti DLL4 nanobody fused to truncated form of Pseudomonas exotoxin: As a novel immunotoxin to inhibit of cell proliferation and neovascularization.

  2022cites this paper
• Molecular Network of Colorectal Cancer and Current Therapeutic Options

  2022cites this paper
• Notch in Human Cancers—A Complex Tale

  2021cites this paper
• Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway

  2021cites this paper
• Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives

  2021cites this paper
• Unveiling osteosarcoma responses to DAPT combined with cisplatin by using confocal Raman microscopy.

  2021cites this paper
• Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models

  2021cites this paper
• Anti-Inflammatory Molecular Mechanism and Contribution of Drug Transport Molecules in Colorectal Cancer Cells

  2021cites this paper
• DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway.

  2021influential citation
• NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target.

  2021cites this paper
• Combined inhibition of STAT and Notch signalling effectively suppresses tumourigenesis by inducing apoptosis and inhibiting proliferation, migration and invasion in glioblastoma cells

  2021cites this paper
• A peptide derived from D. melanogaster Hairless protein promotes the negative regulation of Notch Aberrant Constitutive Signaling on human breast cancer cells

  2021cites this paper
• Notch Signaling Pathway in Cancer—Review with Bioinformatic Analysis

  2021cites this paper
• Delta-like 1 homolog (DLK1) as a possible therapeutic target and its application to radioimmunotherapy using 125I-labelled anti-DLK1 antibody in lung cancer models (HOT1801 and FIGHT004).

  2021cites this paper
• Up-regulation of miR-204 inhibits proliferation, invasion and apoptosis of gallbladder cancer cells by targeting Notch2

  2021cites this paper
• Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia

  2021cites this paper
• Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer.

  2020cites this paper
• Autophagy in tumor and tumor microenvironment

  2020cites this paper
• Notch signalling pathway in development of cholangiocarcinoma

  2020cites this paper
• Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness

  2020influential citation
• Basic and Translational Models of Cooperative Oncogenesis

  2020cites this paper
• Increased Expression of Delta-like Ligand 4 in Mycosis Fungoides

  2020cites this paper
• Effects of Diesel Exhaust Particles on Mouse Gastric Stem Cells

  2020cites this paper
• Loss of HES-1 Expression Predicts a Poor Prognosis for Small Intestinal Adenocarcinoma Patients

  2020influential citation
• UNDERSTANDING TRIPLE NEGATIVE BREAST CANCER: A REVIEW ON MOLECULAR SIGNALING PATHWAYS

  2020cites this paper
• A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions

  2020cites this paper
• Bioinformatic Analysis Linking Genomic Defects to Chemosensitivity and Mechanism of Action

  2020cites this paper
• Targeting Pathways in GI Malignancies

  2020cites this paper
• Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action

  2020cites this paper
• Notch Signaling Function in the Angiocrine Regulation of Tumor Development

  2020cites this paper
• Long noncoding RNAs in osteosarcoma via various signaling pathways

  2020cites this paper
• Impaired activation of Notch-1 signaling hinders repair processes of bronchial epithelial cells exposed to cigarette smoke.

  2020cites this paper
• A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer

  2020cites this paper
• Notch1/2/3/4 are prognostic biomarker and correlated with immune infiltrates in gastric cancer

  2020cites this paper
• Relevance of Autophagy in Cancer Stem Cell and Therapeutic

  2020cites this paper
• Naringin and naringeninin as anticancer agents and adjuvants in cancer combination therapy; efficacy and molecular mechanisms of action, a comprehensive narrative review.

  2020cites this paper
• Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer

  2020cites this paper
• Mutational analysis of extranodal marginal zone lymphoma using next generation sequencing

  2019cites this paper
• Co‐Expression Analysis Reveals Mechanisms Underlying the Varied Roles of NOTCH1 in NSCLC

  2019cites this paper
• Notch as an Immunologic Basis of Cancer Disparities.

  2019cites this paper
• Overexpression of Notch3 is associated with metastasis and poor prognosis in osteosarcoma patients

  2019cites this paper
• Bmo-miR-79 downregulates the expression of BmEm4 in the silkworm, Bombyx mori.

  2019cites this paper
• GXYLT2 accelerates cell growth and migration by regulating the Notch pathway in human cancer cells

  2019cites this paper
• Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.

  2019cites this paper
• DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail

  2019cites this paper
• Novel Therapeutic Approaches and Targets for Ovarian Cancer

  2019cites this paper
• A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody–drug conjugate, in patients with breast cancer and other advanced solid tumors

  2019cites this paper
• Decreased expression of miR-184 restrains the growth and invasion of endometrial carcinoma cells through CDC25A-dependent Notch signaling pathway.

  2019cites this paper
• Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702).

  2019cites this paper
• The ethyl acetate extracts of radix trichosanthis protect retinal vascular endothelial cells from high glucose-induced injury.

  2019cites this paper
• Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies

  2019cites this paper
• Increasing Evidence for and a Word of Caution About an Association Between Cancer and Congenital Heart Disease.

  2019cites this paper
• Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies

  2019cites this paper
• Additive Pharmacological Interaction between Cisplatin (CDDP) and Histone Deacetylase Inhibitors (HDIs) in MDA-MB-231 Triple Negative Breast Cancer (TNBC) Cells with Altered Notch1 Activity—An Isobolographic Analysis

  2019cites this paper
• Notch signaling inhibition induces G0/G1 arrest in murine Leydig cells

  2019cites this paper
• MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis.

  2019cites this paper
• THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

  2019cites this paper