Differences in the Expression of Heat-Shock Proteins and Antioxidant Enzymes between Human and Rodent Pancreatic Islets: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Molecular Medicine

• Publication date

  1995-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF03401895PMID 8612203PMCID PMC2230012
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1994influential reference
• Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines.

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• Regulation of cellular glutathione.

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  1986cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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