SCIENCE@home

Towards a consensus on datasets and evaluation metrics for developing B‐cell epitope prediction tools

J. Greenbaum,P. Andersen,M. Blythe,H. Bui,R. Cachau,J. Crowe,M. Davies,A. Kolaskar,O. Lund,S. Morrison,B. Mumey,Yanay Ofran,J. Pellequer,C. Pinilla,J. Ponomarenko,Gajendra P. Raghava,M. V. van Regenmortel,E. Roggen,A. Sette,A. Schlessinger,Johannes Sollner,M. Zand,Bjoern Peters

Published 2007 in Journal of Molecular Recognition

ABSTRACT

A B‐cell epitope is the three‐dimensional structure within an antigen that can be bound to the variable region of an antibody. The prediction of B‐cell epitopes is highly desirable for various immunological applications, but has presented a set of unique challenges to the bioinformatics and immunology communities. Improving the accuracy of B‐cell epitope prediction methods depends on a community consensus on the data and metrics utilized to develop and evaluate such tools. A workshop, sponsored by the National Institute of Allergy and Infectious Disease (NIAID), was recently held in Washington, DC to discuss the current state of the B‐cell epitope prediction field. Many of the currently available tools were surveyed and a set of recommendations was devised to facilitate improvements in the currently existing tools and to expedite future tool development. An underlying theme of the recommendations put forth by the panel is increased collaboration among research groups. By developing common datasets, standardized data formats, and the means with which to consolidate information, we hope to greatly enhance the development of B‐cell epitope prediction tools. Copyright © 2007 John Wiley & Sons, Ltd.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-42 of 42 references · Page 1 of 1

CITED BY

Showing 1-100 of 268 citing papers · Page 1 of 3

123
Next