General introduction to altitude adaptation and mountain sickness

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Scandinavian Journal of Medicine & Science in Sports

• Publication date

  2008-07-08

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1111/j.1600-0838.2008.00827.xPMID 18665947
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Live high, train low at natural altitude

  2008cited by this paper
• Training in hypoxia and its effects on skeletal muscle tissue

  2008cited by this paper
• Effects of various training modalities on blood volume

  2008cited by this paper
• Classical altitude training

  2008cited by this paper
• Skeletal Muscle Adaptations to Prolonged Exposure to Extreme Altitude: A Role of Physical Activity?

  2008cited by this paper
• Extracellular pH defense against lactic acid in untrained and trained altitude residents

  2008cited by this paper
• 3-week hiking holidays at moderate altitude do not impair cardiac function in individuals with metabolic syndrome.

  2008cited by this paper
• Counterpoint: the lactate paradox does not occur during exercise at high altitude.

  2007cited by this paper
• Nonhematological mechanisms of improved sea-level performance after hypoxic exposure.

  2007cited by this paper
• Timing the arrival at 2340 m altitude for aerobic performance

  2007cited by this paper
• The lactate paradox: does acclimatization to high altitude affect blood lactate during exercise?

  2007cited by this paper
• Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume

  2007cited by this paper
• COUNTERPOINT: THE LACTATE PARADOX DOES NOT OCCUR DURING EXERCISE AT HIGH ALTITUDE

  2007cited by this paper
• Exercise and hypoxia: the role of the autonomic nervous system.

  2007cited by this paper
• Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans.

  2007cited by this paper
• Comments on point:counterpoint: "the lactate paradox does/does not occur during exercise at high altitude".

  2007cited by this paper
• Effect of aircraft-cabin altitude on passenger discomfort.

  2007influential reference
• Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives

  2006cited by this paper
• Linear decrease in .VO2max and performance with increasing altitude in endurance athletes.

  2006cited by this paper
• Exercise economy does not change after acclimatization to moderate to very high altitude

  2006cited by this paper
• Both Tadalafil and Dexamethasone May Reduce the Incidence of High-Altitude Pulmonary Edema

  2006cited by this paper
• Training for endurance and strength: lessons from cell signaling.

  2006cited by this paper
• Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes.

  2006cited by this paper
• Physiological aspects of high-altitude pulmonary edema.

  2005cited by this paper
• Sleep in athletes undertaking protocols of exposure to nocturnal simulated altitude at 2650 m.

  2005cited by this paper
• High Altitude Illness

  2005cited by this paper
• Individual variation in the reduction of heart rate and performance at lactate thresholds in acute normobaric hypoxia.

  2005influential reference
• Living high-training low: tolerance and acclimatization in elite endurance athletes

  2005cited by this paper
• Enhanced hypoxic pulmonary vasoconstriction in families of adults or children with idiopathic pulmonary arterial hypertension.

  2005cited by this paper
• Carbohydrate supplementation improves time-trial cycle performance during energy deficit at 4,300-m altitude.

  2005cited by this paper
• A three-week traditional altitude training increases hemoglobin mass and red cell volume in elite biathlon athletes.

  2005cited by this paper
• Acute sleep responses in a normobaric hypoxic tent.

  2005cited by this paper
• Exercise and the Environment

  2004cited by this paper
• Plasma volume expansion does not increase maximal cardiac output or VO2 max in lowlanders acclimatized to altitude.

  2004influential reference
• Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle

  2004influential reference
• Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives.

  2004influential reference
• Determinants of maximal oxygen uptake in severe acute hypoxia.

  2003cited by this paper
• Response of Skeletal Muscle Mitochondria to Hypoxia

  2003cited by this paper
• Why is VO2 max after altitude acclimatization still reduced despite normalization of arterial O2 content?

  2003influential reference
• Human skeletal muscle and erythrocyte proteins involved in acid‐base homeostasis: adaptations to chronic hypoxia

  2003cited by this paper
• Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia

  2003cited by this paper
• Performing at extreme altitude: muscle cellular and subcellular adaptations

  2003cited by this paper
• High altitude: An exploration of human adaptation

  2002cited by this paper
• Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m.

  2002cited by this paper
• Highest Permanent Human Habitation

  2002cited by this paper
• Pulmonary extravascular fluid accumulation in climbers.

  2002cited by this paper
• Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlanders.

  2002cited by this paper
• Pulmonary extravascular fluid accumulation in climbers.

  2002cited by this paper
• Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate.

  2002cited by this paper
• Why is V˙ O 2 max after altitude acclimatization still reduced despite normalization of arterial O 2 content?

  2002influential reference
• Effect of blood haemoglobin concentration on V̇o2,max and cardiovascular function in lowlanders acclimatised to 5260 m

  2002cited by this paper
• Current Trends in Altitude Training

  2001cited by this paper
• “Living high − training low” altitude training improves sea level performance in male and female élite runners

  2001cited by this paper
• Parasympathetic Neural Activity Accounts for the Lowering of Exercise Heart Rate at High Altitude

  2001influential reference
• High Altitude : An Exploration of Human Adaptation

  2001cited by this paper
• High-altitude illness.

  2001cited by this paper
• Heart rate response to hypoxic exercise: role of dopamine D2-receptors and effect of oxygen supplementation.

  2001cited by this paper
• Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review

  2000cited by this paper
• Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema.

  2000cited by this paper
• Downregulation of Na+-K+-ATPase pumps in skeletal muscle with training in normobaric hypoxia.

  1999cited by this paper
• High altitude pulmonary edema.

  1999cited by this paper
• High-altitude cerebral edema evaluated with magnetic resonance imaging: clinical correlation and pathophysiology.

  1998cited by this paper
• Maximal and submaximal exercise performance at altitude.

  1998cited by this paper
• Increased left ventricular muscle mass after long-term altitude training in athletes.

  1997influential reference
• "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance.

  1997cited by this paper
• Reduced performance of male and female athletes at 580 m altitude

  1997cited by this paper
• Exercise and the environment: focus on altitude.

  1996influential reference
• Nocturnal periodic breathing and the development of acute high altitude illness.

  1996cited by this paper
• Altitude and beta-blockade augment glucose utilization during submaximal exercise.

  1996cited by this paper
• Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude.

  1996influential reference
• High-altitude pulmonary edema.

  1996cited by this paper
• Aerobic fitness influences the response of maximal oxygen uptake and lactate threshold in acute hypobaric hypoxia.

  1995cited by this paper
• Acute Mountain Sickness in a General Tourist Population at Moderate Altitudes

  1993cited by this paper
• Increased arterial pressure after acclimatization to 4300 m: possible role of norepinephrine.

  1992cited by this paper
• Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m.

  1992cited by this paper
• Increased energy intake minimizes weight loss in men at high altitude.

  1992cited by this paper
• Operation Everest II: arterial oxygen saturation and sleep at extreme simulated altitude.

  1992cited by this paper
• Prevention of high-altitude pulmonary edema by nifedipine.

  1991cited by this paper
• Increased dependence on blood glucose after acclimatization to 4,300 m.

  1991cited by this paper
• Prevalence of acute mountain sickness in the Swiss Alps.

  1990cited by this paper
• Limb skeletal muscle adaptation in athletes after training at altitude.

  1990cited by this paper
• Decreased cardiac response to isoproterenol infusion in acute and chronic hypoxia.

  1989cited by this paper
• Caractéristiques physiologiques des alpinistes de haute altitude

  1988cited by this paper
• Decreased cardiac response to isoproterenol infusion in acute and chronic hypoxia

  1988cited by this paper
• Enhanced left ventricular systolic performance at high altitude during Operation Everest II.

  1987cited by this paper
• Lactate during exercise at extreme altitude.

  1986cited by this paper
• Potassium and sodium shifts during in vitro isometric muscle contraction, and the time course of the ion-gradient recovery

  1986cited by this paper
• Pulmonary gas exchange in humans exercising at sea level and simulated altitude.

  1986cited by this paper
• Cardiovascular adaptation to exercise at high altitude.

  1986cited by this paper
• Low acute hypoxic ventilatory response and hypoxic depression in acute altitude sickness.

  1986cited by this paper
• Skeletal Muscle

  1985cited by this paper
• Skeletal Muscle Adaptability: Significance for Metabolism and Performance

  1983influential reference
• Control of ventilation in climbers to extreme altitude.

  1982cited by this paper
• High Altitude Pulmonary Edema: Analysis of 166 Cases

  1982cited by this paper
• Control of Ventilation

  1981cited by this paper
• Skeletal Muscle Fiber Size and Capillarity 1

  1978cited by this paper
• Effects of hypoxia on capillary density and fiber composition in rat skeletal muscle

  1977cited by this paper
• Effects of high-altitude exposure on submaximal endurance capacity of men.

  1974cited by this paper
• Control of exercise hyperpnea under varying durations of exposure to moderate hypoxia.

  1972cited by this paper
• Acute mountain sickness.

  1969cited by this paper

• Heat Acclimation During the Third Week of a Live-High-Train-High Training Camp Does Not Impair the Hematological and Perceptual Responses to Altitude.

  2026cites this paper
• The effect of sodium bicarbonate mini-tablets in a carbohydrate hydrogel on prolonged high-intensity cycling performance and metabolism in acute normobaric hypoxia.

  2026cites this paper
• Clinical characteristics of high-altitude interstitial lung disease: a two-center, retrospective, observational study

  2026cites this paper
• Bridging scale-mismatch: Managing neglected anthropogenic stresses on environmental sustainability on the Tibet Plateau

  2026cites this paper
• Affective and fatigue responses to incremental exercise: the effect of hypoxic and normoxic training protocols

  2026cites this paper
• Definitions and consensus recommendations on critical care medicine at altitude from the Expert Committee on Critical Care Medicine at altitude of the Pan-American and Iberian Federation of Critical Care Medicine and Intensive Care.

  2025cites this paper
• Hyperbaric Oxygen Treatment for Chronic Insomnia at High Altitude: A Prospective, Randomized, Open-Label, Parallel-Group Trial.

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• The impact of air pollution on influenza incidence in high-altitude regions: a time-stratified case-crossover study based on Qinghai Province

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• Cognitive and Physiological Assessment in a Mars Analog Habitat: Implications for Aerospace Medical Monitoring in Hypobaric Hypoxia

  2025cites this paper
• Match Running Performance by Playing Position in Elite Colombian Women’s Professional Soccer

  2025cites this paper
• Response.

  2025cites this paper
• Determination of the role of aerobic and anaerobic training at different altitude on hypoxia-induced factor 1, hemoglobin, iron, erythropoietin, hepcidin, and nitric oxide.

  2025cites this paper
• Definiciones y recomendaciones de consenso sobre la medicina crítica en la altitud del Comité de Expertos de Medicina Crítica en la altitud de la Federación Panamericana e Ibérica de Medicina Crítica y Terapia Intensiva

  2025cites this paper
• Cardiorespiratory and oxygenation responses in iron-deficient anemic women during whole-body exercise under moderate hypoxia.

  2025cites this paper
• Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m

  2025cites this paper
• Recent updates on sickness during Acute High-altitude hypoxic exposure and its management

  2025cites this paper
• Dysregulation of metabolites and high-altitude illnesses development under plateau conditions

  2025cites this paper
• Lactate Thresholds and Performance in Young Cross-Country Skiers Before and After the Competitive Season: Insights from Laboratory Roller-Ski Tests in Normoxic and Hypoxic Conditions

  2025cites this paper
• The Temporal Effects of Altitude and Low Energy Availability Manipulation on Resting Metabolic Rate in Female Race Walkers

  2024cites this paper
• Effect of Acute Altitude Exposure on Anaerobic Threshold Assessed by a Novel Electrocardiogram-Based Method

  2024cites this paper
• A finer-grained high altitude EEG dataset for hypoxia levels assessment

  2024cites this paper
• Review of Athletic Guidelines for High-Altitude Training and Acclimatization

  2024cites this paper
• On the mechanisms of stress-induced human spleen contraction: training for a higher blood oxygen-carrying capacity

  2024cites this paper
• Spirometry findings of chronic lung disease in high-altitude residents of Ladakh (>11,000 feet above sea level).

  2024cites this paper
• Physiological factors that affect maximal oxygen uptake and lactate threshold during endurance training

  2024cites this paper
• Blood Glucose During High Altitude Trekking in Young Healthy Adults

  2024cites this paper
• Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance

  2024cites this paper
• Evaluation of suitability, adaptability, and reserve potential of construction land on the Qinghai-Tibet Plateau

  2024cites this paper
• Female performance in skyrunning: biological and psychosocial aspects.

  2024cites this paper
• Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules

  2024cites this paper
• High‐level performances following low altitude training and tapering in warm environments in elite racewalkers

  2024cites this paper
• Effects of various living-low and training-high modes with distinct training prescriptions on sea-level performance: A network meta-analysis

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• Competing at Altitude Reduces In-Match Physical Demands of Professional Soccer Players Compared With Sea Level.

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• Effects of Altitude training on Ethiopian endurance athletes recovery heart rate and hematological variables

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• Menstrual cycle does not impact the hypoxic ventilatory response and acute mountain sickness prediction

  2024cites this paper
• A high altitude respiration and SpO2 dataset for assessing the human response to hypoxia

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• Acute and cumulative effects of hypoxia exposure in people with Parkinson's disease: A scoping review and evidence map.

  2023cites this paper
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  2023cites this paper
• 高原脑水肿小鼠模型的建立与鉴定

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• Serum vascular endothelial growth factor is a potential biomarker for acute mountain sickness

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• Nutrition and Hydration for High-Altitude Alpinism: A Narrative Review

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• Recommendations for Women in Mountain Sports and Hypoxia Training/Conditioning

  2023cites this paper
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• Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments.

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• The Emerging Role of Hypoxic Training for the Equine Athlete

  2023cites this paper
• Hiking-time formulas: a review

  2023influential citation
• Recent Progress in the Understanding and Management of Acute Mountain Sickness: A Narrative Review.

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• Hypoxia and hemorheological properties in older individuals.

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• Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

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• Respiratory responses to hypoxia during rest and exercise in individuals born pre-term: a state-of-the-art review

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