Functional analysis of the PTH/PTHrP network of ligands and receptors.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Recent Progress in Hormone Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 9769712
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.

  1998cited by this paper
• Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.

  1997cited by this paper
• Evidence for a parathyroid hormone-2 receptor selective ligand in the hypothalamus.

  1997cited by this paper
• Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

  1996cited by this paper
• PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth

  1996cited by this paper
• Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

  1996cited by this paper
• Defining the roles of parathyroid hormone-related protein in normal physiology.

  1996cited by this paper
• Converting Parathyroid Hormone-related Peptide (PTHrP) into a Potent PTH-2 Receptor Agonist*

  1996cited by this paper
• Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor.

  1996cited by this paper
• The expression of parathyroid hormone and parathyroid hormone-related protein in developing rat parathyroid glands.

  1996cited by this paper
• Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.

  1996cited by this paper
• Identification and Functional Expression of a Receptor Selectively Recognizing Parathyroid Hormone, the PTH2 Receptor (*)

  1995cited by this paper
• Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.

  1995cited by this paper
• Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.

  1995cited by this paper
• Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(1-84)

  1995cited by this paper
• A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.

  1995cited by this paper
• Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions.

  1994cited by this paper
• Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

  1994cited by this paper
• Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation

  1993cited by this paper
• Expression of parathyroid hormone-related protein mRNA by uterine tissues and extraembryonic membranes during gestation in rats.

  1993cited by this paper
• Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

  1992cited by this paper
• A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

  1991cited by this paper
• A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111].

  1991cited by this paper
• Second messenger signaling in the regulation of collagenase production by osteogenic sarcoma cells.

  1989cited by this paper
• Stimulation of ovine placental calcium transport by purified natural and recombinant parathyroid hormone-related protein (PTHrP) preparations.

  1989cited by this paper
• Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.

  1988cited by this paper
• Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene.

  1988cited by this paper
• Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy.

  1988cited by this paper
• A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

  1987cited by this paper
• Mutations affecting segment number and polarity in Drosophila

  1980cited by this paper
• Bovine parathyroid hormone: minimum chain length of synthetic peptide required for biological activity.

  1973cited by this paper
• The amino acid sequence of bovine parathyroid hormone I.

  1970cited by this paper

• Parathyroid hormone receptors in GtoPdb v.2025.3

  2025cites this paper
• Parathyroid hormone receptors in GtoPdb v.2023.1

  2023cites this paper
• Parathyroid hormone receptors in GtoPdb v.2021.2

  2021cites this paper
• Parathyroid hormone receptors in GtoPdb v.2021.3

  2021cites this paper
• Identification of osteogenic progenitor cell-targeted peptides that augment bone formation

  2020cites this paper
• Cellular, molecular and genetical overview of avian tibial dyschondroplasia.

  2020cites this paper
• Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Intermittent parathyroid hormone promotes cementogenesis in a PKA- and ERK1/2-dependent manner.

  2019cites this paper
• Pseudohypoparathyroïdie : distorsion du ratio de transmission maternelle des mutations perte de fonction de GNAS

  2018cites this paper
• The Changing Concept of Gut Endocrinology.

  2017cites this paper
• PTH and PTHR1 in osteocytes. New insights into old partners

  2017cites this paper
• Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain‐to‐bone signaling pathway

  2017cites this paper
• Vitamin D Deficiency: "At Risk" Patient Populations and Potential Drug Interactions

  2016cites this paper
• Effects of corticosterone on the metabolic activity of cultured chicken chondrocytes

  2015cites this paper
• Gastrointestinal hormone research – with a Scandinavian annotation

  2015cites this paper
• Gastrointestinal hormones and their targets.

  2014cites this paper
• Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease

  2014influential citation
• Wasf2: a novel target of intermittent parathyroid hormone administration.

  2013cites this paper
• The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes.

  2013cites this paper
• Anti-Osteoporotic Drugs and Vascular Calcification: The Bidirectional Calcium Traffic

  2013cites this paper
• Escalated Expression of Matrix Metalloproteinases in Osteoarthritis

  2013cites this paper
• Major Signaling Pathways Regulating the Proliferation and Differentiation of Mesenchymal Stem Cells

  2013cites this paper
• Parathyroid Hormone and Calcium Homeostasis

  2012cites this paper
• Biochemistry, Physiology, and Pathophysiology of Parathyroid Hormone-Related Peptide

  2012cites this paper
• Calcium in Internal Medicine

  2011influential citation
• Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

  2011cites this paper
• Apical membrane segregation of phosphatidylinositol-4,5-bisphosphate influences parathyroid hormone 1 receptor compartmental signaling and localization via direct regulation of ezrin in LLC-PK1 cells.

  2011cites this paper
• Molecular signaling within growth plates of the radius and tibia after periosteal stripping: an experimental study in lambs

  2010cites this paper
• Management of Growth Plate Injuries

  2010cites this paper
• Growth Factor Mediated Regulation of Beta Cell Survival

  2010cites this paper
• TIP39 (Tuberoinfundibular Peptide of 39 Residues)

  2009cites this paper
• Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.

  2009cites this paper
• Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats.

  2009influential citation
• Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human.

  2009cites this paper
• Regulation of osteogenic differentiation during skeletal development.

  2008influential citation
• Renal Osteodystrophy: Pathogenic Mechanisms and Therapeutic Options

  2008cites this paper
• Parathyroid hormone signaling through low-density lipoprotein-related protein 6.

  2008cites this paper
• Tuberoinfundibular peptide of 39 residues in the embryonic and early postnatal rat brain.

  2008cites this paper
• In Vivo Targeted Deletion of Calpain Small Subunit, Capn4, in Cells of the Osteoblast Lineage Impairs Cell Proliferation, Differentiation, and Bone Formation*

  2008cites this paper
• Continuous Activation of Gαq in Osteoblasts Results in Osteopenia through Impaired Osteoblast Differentiation*

  2007cites this paper
• Mice expressing a constitutively active PTH/PTHrP receptor in osteoblasts show reduced callus size but normal callus morphology during fracture healing

  2007cites this paper
• Parathyroid hormone/parathyroid hormone‐related peptide modulates growth of avian sternal cartilage via chondrocytic proliferation

  2007cites this paper
• A topical parathyroid hormone/parathyroid hormone-related peptide receptor antagonist stimulates hair growth in mice.

  2007cites this paper
• The role of the osteoclast during endochondral ossification in a rat fracture model

  2007cites this paper
• Molecular basis for skeletal variation: insights from developmental genetic studies in mice.

  2007cites this paper
• Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats.

  2007cites this paper
• Expression of PTH1R constructs in LLC-PK1 cells: protein nuclear targeting is mediated by the PTH1R NLS.

  2007cites this paper
• In Vitro & In Vivo Effect of Parathyroid Hormone Analogue (1-14) Containing α-amino-iso-butyric Acid Residue (Aib)1,3

  2006cites this paper
• The PTHrP/PTH.1-R bioregulation system in cardiac hypertrophy: possible therapeutic implications.

  2006cites this paper
• Parathyroid hormone-related peptide : a key factor in cell adhesion.

  2006cites this paper
• Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells.

  2006cites this paper
• Identification of DU 145 prostate cancer cell proteins that bind to the carboxy-terminal peptide of human PTHrP in vitro.

  2006cites this paper
• Regulator of G‐protein signaling (RGS) proteins differentially control chondrocyte differentiation

  2006cites this paper
• BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter

  2006cites this paper
• Restoration of growth plate function following radiotherapy is driven by increased proliferative and synthetic activity of expansions of chondrocytic clones

  2006cites this paper
• Postnatal development and gender‐dependent expression of TIP39 in the rat brain

  2006cites this paper
• GSK3 and PKB/Akt are associated with integrin‐mediated regulation of PTHrP, IL‐6 and IL‐8 expression in FG pancreatic cancer cells

  2005cites this paper
• The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit.

  2005cites this paper
• Extracellular calcium and parathyroid hormone-related peptide signaling modulate the pace of growth plate chondrocyte differentiation.

  2005cites this paper
• PTHrP gene expression in cancer: do all paths lead to Ets?

  2005cites this paper
• Molecular mechanisms of endochondral bone development.

  2005cites this paper
• Heat shock protein-70 expressed on the surface of cancer cells binds parathyroid hormone-related protein in vitro.

  2005cites this paper
• Chapter 9 – Calcium Homeostasis and Disorders of Calcium Metabolism During Pregnancy and Lactation

  2004cites this paper
• The Extracellular Matrix Differentially Regulates the Expression of PTHrP and the PTH/PTHrP Receptor in FG Pancreatic Cancer Cells

  2004cites this paper
• A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.

  2004cites this paper
• Functional importance of Myc-associated zinc finger protein for the human parathyroid hormone (PTH)/PTH-related peptide receptor-1 P2 promoter constitutive activity.

  2004cites this paper
• Parathyroid Hormone (PTH)

  2004cites this paper
• Effects of parathyroid hormone on cancellous bone mass and structure in osteoporosis.

  2004cites this paper
• Molecular and genetic mechanisms of osteoporosis: implication for treatment.

  2003cites this paper
• PTHrP, PTHr, and FGFR3 are involved in the process of endochondral ossification in human osteophytes

  2003cites this paper
• Localization of estrogen receptors-alpha and -beta and androgen receptor in the human growth plate at different pubertal stages.

  2003cites this paper
• Expression and distribution of tuberoinfundibular peptide of 39 residues in the rat central nervous system

  2003cites this paper
• A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosis.

  2003cites this paper
• Neurons containing tuberoinfundibular peptide of 39 residues project to limbic, endocrine, auditory and spinal areas in rat.

  2003cites this paper
• ATP dependent Ca2+ transport across basal membrane of human syncytiotrophoblast in pregnancies complicated by intrauterine growth restriction or diabetes.

  2003cites this paper
• Effects of combined treatment of insulin and human parathyroid hormone(1-34) on cancellous bone mass and structure in streptozotocin-induced diabetic rats.

  2003cites this paper
• Teriparatide (Human Parathyroid Hormone (1–34)) Inhibits Osteogenic Vascular Calcification in Diabetic Low Density Lipoprotein Receptor-deficient Mice*

  2003cites this paper
• Normal proliferation and differentiation of Hoxc-8 transgenic chondrocytes in vitro

  2003cites this paper
• Localization of estrogen receptors- (cid:1) and - (cid:2) and androgen receptor in the human growth plate at different pubertal stages

  2003cites this paper
• Estimation of bioavailability of salmon calcitonin from the hypocalcemic effect in rats (I): pharmacokinetic-pharmacodynamic modeling based on the endogenous Ca regulatory system.

  2003cites this paper
• Parathyroid hormone-related peptide and cardiovascular system.

  2003cites this paper
• Syndromes paranéoplasiques endocriniens

  2003cites this paper
• PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development.

  2003cites this paper
• The Parathyroid Gland

  2002cites this paper
• Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception

  2002cites this paper
• Purification and Characterization of a Receptor for Human Parathyroid Hormone and Parathyroid Hormone-related Peptide*

  2002cites this paper
• Mechanisms balancing skeletal matrix synthesis and degradation.

  2002cites this paper
• Role of c‐fos in the regulation of type X collagen gene expression by PTH and PTHrP: Localization of a PTH/PTHrP‐responsive region in the human COL10A1 enhancer

  2002cites this paper
• PTH receptors and apoptosis in osteocytes.

  2002cites this paper
• Four distinct chondrocyte populations in the fetal bovine growth plate: highest expression levels of PTH/PTHrP receptor, Indian hedgehog, and MMP-13 in hypertrophic chondrocytes and their suppression by PTH (1-34) and PTHrP (1-40).

  2002cites this paper
• A novel PTH/PTHrP receptor (PPRc) mutation: The ongoing tale of PPRc and the growth plate becomes more complex

  2002cites this paper
• Of mice and men, recapitulation of Blomstrand's chondrodysplasia.

  2001cites this paper
• Parathyroid Hormone (PTH)-(1–14) and -(1–11) Analogs Conformationally Constrained by α-Aminoisobutyric Acid Mediate Full Agonist Responses via the Juxtamembrane Region of the PTH-1 Receptor*

  2001cites this paper
• Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion.

  2001cites this paper
• Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation

  2001cites this paper
• CHAPTER 12 – Cellular Actions of Parathyroid Hormone on Osteoblast and Osteoclast Differentiation

  2001cites this paper
• Parathyroid hormone‐related peptide expression in the epiphyseal growth plate of the juvenile chicken: Evidence for the origin of the parathyroid hormone‐related peptide found in the epiphyseal growth plate

  2001cites this paper
• Evidence that anabolic effects of PTH on bone require IGF-I in growing mice.

  2001cites this paper
• Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets

  2001cites this paper
• Molecular properties of the PTH/PTHrP receptor.

  2001cites this paper