Cytokine Signaling Regulates the Outcome of Intracellular Macrophage Parasitism by Cryptococcus neoformans

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Infection and Immunity

• Publication date

  2009-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.00297-09PMID 19487474PMCID PMC2715691
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung.

  2009cited by this paper
• Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen.

  2008cited by this paper
• Profile of Central Nervous System Disease in HIV/AIDS Patients With Special Reference to Cryptococcal Infections

  2008cited by this paper
• Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans

  2008cited by this paper
• IL-13 Induces Disease-Promoting Type 2 Cytokines, Alternatively Activated Macrophages and Allergic Inflammation during Pulmonary Infection of Mice with Cryptococcus neoformans1

  2007influential reference
• Protection against Cryptococcosis by Using a Murine Gamma Interferon-Producing Cryptococcus neoformans Strain

  2007influential reference
• Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages

  2007cited by this paper
• Direct cell-to-cell spread of a pathogenic yeast

  2007cited by this paper
• Spread of Cryptococcus gattii in British Columbia, Canada, and Detection in the Pacific Northwest, USA

  2007cited by this paper
• Modulation of the Pulmonary Type 2 T-Cell Response to Cryptococcus neoformans by Intratracheal Delivery of a Tumor Necrosis Factor Alpha-Expressing Adenoviral Vector

  2007cited by this paper
• Report Expulsion of Live Pathogenic Yeast by Macrophages

  2006influential reference
• TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis: Role of IL-17-Producing T Cells1

  2006influential reference
• Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages.

  2006cited by this paper
• Deciphering the Model Pathogenic Fungus Cryptococcus Neoformans

  2005cited by this paper
• Role of IFN-γ in Regulating T2 Immunity and the Development of Alternatively Activated Macrophages during Allergic Bronchopulmonary Mycosis 1

  2005cited by this paper
• IFN-γ at the Site of Infection Determines Rate of Clearance of Infection in Cryptococcal Meningitis1

  2005cited by this paper
• Two patients with cryptococcal meningitis and idiopathic CD4 lymphopenia: defective cytokine production and reversal by recombinant interferon- gamma therapy.

  2004cited by this paper
• Role of interleukin-4 in resistance to Cryptococcus neoformans infection.

  2004influential reference
• Role of Phagocytosis in the Virulence of Cryptococcus neoformans

  2004cited by this paper
• Role of Extracellular Phospholipases and Mononuclear Phagocytes in Dissemination of Cryptococcosis in a Murine Model

  2004cited by this paper
• Recapitulation of the Sexual Cycle of the Primary Fungal Pathogen Cryptococcus neoformans var. gattii: Implications for an Outbreak on Vancouver Island, Canada

  2003cited by this paper
• Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.

  2003cited by this paper
• Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia.

  2002cited by this paper
• Genetics of Cryptococcus neoformans.

  2002cited by this paper
• Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm

  2002cited by this paper
• Intracellular parasitism of macrophages by Cryptococcus neoformans.

  2001cited by this paper
• Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans

  2001cited by this paper
• Efficacy of Recombinant Gamma Interferon for Treatment of Systemic Cryptococcosis in SCID Mice

  2001cited by this paper
• Cryptococcus neoformans Is a Facultative Intracellular Pathogen in Murine Pulmonary Infection

  2000cited by this paper
• Urease as a Virulence Factor in Experimental Cryptococcosis

  2000cited by this paper
• Enhancement of antifungal chemotherapy by interferon-gamma in experimental systemic cryptococcosis.

  2000cited by this paper
• TH1 to TH2 Shift of Cytokines in Peripheral Blood of HIV‐Infected Patients Is Detectable by Reverse Transcriptase Polymerase Chain Reaction but Not by Enzyme‐Linked Immunosorbent Assay Under Nonstimulated Conditions

  2000cited by this paper
• Persistent Cryptococcus neoformansPulmonary Infection in the Rat Is Associated with Intracellular Parasitism, Decreased Inducible Nitric Oxide Synthase Expression, and Altered Antibody Responsiveness to Cryptococcal Polysaccharide

  2000cited by this paper
• TH1 to TH2 shift of cytokines in peripheral blood of HIV-infected patients is detectable by reverse transcriptase polymerase chain reaction but not by enzyme-linked immunosorbent assay under nonstimulated conditions.

  2000cited by this paper
• Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines.

  1999cited by this paper
• Epidemiological Evidence for Dormant Cryptococcus neoformans Infection

  1999cited by this paper
• Tumor necrosis factor alpha enhances antifungal activities of polymorphonuclear and mononuclear phagocytes against Aspergillus fumigatus.

  1998influential reference
• Interleukin-12 Is Essential for a Protective Th1 Response in Mice Infected with Cryptococcus neoformans

  1998influential reference
• Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.

  1997cited by this paper
• IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice.

  1997cited by this paper
• Role of cytokines in T cell immunity to a pulmonary Cryptococcus neoformans infection.

  1996cited by this paper
• Interferon-gamma reduces the capacity of human alveolar macrophages to inhibit growth of Cryptococcus neoformans in vitro.

  1996cited by this paper
• Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans

  1995cited by this paper
• Interferon gamma increases survival in murine experimental cryptococcosis.

  1995cited by this paper
• T Cell‐Dependent Activation of Macrophages and Enhancement of Their Phagocytic Activity in the Lungs of Mice Inoculated with Heat‐Killed Cryptococcus neoformans: Involvement of IFN‐γ and Its Protective Effect against Cryptococcal Infection

  1995cited by this paper
• Growth inhibition of Cryptococcus neoformans by cultured human monocytes: role of the capsule, opsonins, the culture surface, and cytokines

  1990cited by this paper
• Fungicidal activity of IFN-gamma-activated macrophages. Extracellular killing of Cryptococcus neoformans.

  1989cited by this paper
• Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

  1985cited by this paper
• Phagocytosis of Cryptococcus neoformans by normal and thioglycolate-activated macrophages

  1978cited by this paper
• Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity.

  1975cited by this paper
• Phagocytosis of Cryptococcus neoformans by alveolar macrophages

  1975cited by this paper
• Growth of Cryptococcus neoformans Within Human Macrophages In Vitro

  1973cited by this paper
• In Vitro Phagocytosis and Intracellular Fate of Variously Encapsulated Strains of Cryptococcus neoformans

  1972cited by this paper

• Vomocytosis of Cryptococcus neoformans from Macrophages: from discovery to current understanding.

  2025cites this paper
• Exopolysaccharides of Ganoderma lucidum Activate the NLRP3 Inflammasome, Modulating Phagocytes and the Response of Mice to Infection with Cryptococcus neoformans

  2025cites this paper
• Immune evasion by Cryptococcus gattii in vaccinated mice coinfected with C. neoformans

  2024cites this paper
• Biogenesis, germination, and pathogenesis of Cryptococcus spores

  2024cites this paper
• Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens.

  2023cites this paper
• Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system.

  2023cites this paper
• Innate Pulmonary Phagocytes and Their Interactions with Pathogenic Cryptococcus Species

  2023cites this paper
• Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

  2023cites this paper
• The yeast-human coevolution: Fungal transition from passengers, colonizers, and invaders.

  2023cites this paper
• Reciprocal regulation of TLR4, TLR3 and Macrophage Scavenger Receptor 1 regulates nonopsonic phagocytosis of the fungal pathogen Cryptococcus neoformans

  2023cites this paper
• Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen

  2023cites this paper
• Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection

  2022cites this paper
• Opportunistic pneumonia caused by E. cuniculi in mice immunosuppressed with cyclophosphamide.

  2022cites this paper
• Transcriptional Profiles Elucidate Differential Host Responses to Infection with Cryptococcus neoformans and Cryptococcus gattii

  2022cites this paper
• Vomocytosis of Cryptococcus neoformans cells from murine, bone marrow-derived dendritic cells

  2022cites this paper
• Murine iNOS expression is essential for antifungal defenses in kidneys during disseminated Cryptococcus deneoformans infection

  2021cites this paper
• Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans

  2021cites this paper
• Murine Inducible Nitric Oxide Synthase Expression Is Essential for Antifungal Defenses in Kidneys during Disseminated Cryptococcus deneoformans Infection

  2021cites this paper
• Human Fungal Pathogens: Diversity, Genomics, and Preventions

  2021cites this paper
• Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes

  2020cites this paper
• Efeitos do ácido pantotênico na interação entre Cryptococcus neoformans e macrófagos

  2020cites this paper
• Animal Models of Cryptococcus neoformans in Identifying Immune Parameters Associated With Primary Infection and Reactivation of Latent Infection

  2020cites this paper
• The multiplicity of infection does not affect interactions between Cryptococcus neoformans and macrophages

  2020cites this paper
• PPAR-gamma Fun(gi) With Prostaglandin

  2020cites this paper
• Intracellular Cryptococcus neoformans disrupts the transcriptome profile of M1- and M2-polarized host macrophages

  2020cites this paper
• IL-25 Receptor Signaling Modulates Host Defense against Cryptococcus neoformans Infection

  2020cites this paper
• Production of IL-17A at Innate Immune Phase Leads to Decreased Th1 Immune Response and Attenuated Host Defense against Infection with Cryptococcus deneoformans

  2020cites this paper
• Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of Cryptococcus neoformans

  2020cites this paper
• Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans

  2020cites this paper
• Laccase Affects the Rate of Cryptococcus neoformans Nonlytic Exocytosis from Macrophages

  2020cites this paper
• Quantifying Eicosanoids

  2020cites this paper
• Group 2 Innate Lymphoid Cells (ILC2) Suppress Beneficial Type 1 Immune Responses During Pulmonary Cryptococcosis

  2020cites this paper
• Are Macrophages the Heroes or Villains During Cryptococcosis?

  2019cites this paper
• Phagocytes as central players in the defence against invasive fungal infection.

  2019cites this paper
• O uso de pCramoll como tratamento da criptococose em camundongos imunocompetentes e imunossurimidos

  2019cites this paper
• Vomocytosis: Too Much Booze, Base, or Calcium?

  2019cites this paper
• Antiphagocytic protein 1 increases the susceptibility of Cryptococcus neoformans to amphotericin B and fluconazole

  2019cites this paper
• Vomocytosis: What we know so far

  2019cites this paper
• Translational Regulation Promotes Oxidative Stress Resistance in the Human Fungal Pathogen Cryptococcus neoformans

  2019cites this paper
• Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from Cryptococcus gattii Independently of T Cells

  2019cites this paper
• Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans

  2019cites this paper
• Cryptococcosis in Southern-Brazil: Molecular, antifungal and in vitro cytokine induction studies

  2019influential citation
• 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection

  2019cites this paper
• Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker

  2019cites this paper
• Characterisation of the virulence and determinants of virulence of C. neoformans var. grubii genotypes from HIV infected and uninfected patients in Vietnam

  2018cites this paper
• Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages

  2018cites this paper
• 6 Host Immune Responses Against Pulmonary Fungal Pathogens

  2018cites this paper
• Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

  2018cites this paper
• Differential In Vitro Cytokine Induction by the Species of Cryptococcus gattii Complex

  2018cites this paper
• Immunology of Cryptococcal Infections: Developing a Rational Approach to Patient Therapy

  2018cites this paper
• In vitro and in vivo effect of PD‐1/PD‐L1 blockade on microglia/macrophage activation and T cell subset balance in cryptococcal meningitis

  2018cites this paper
• The Outcome of the Cryptococcus neoformans–Macrophage Interaction Depends on Phagolysosomal Membrane Integrity

  2018cites this paper
• Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection

  2018cites this paper
• The Interplay of Host Autophagy and Eukaryotic Pathogens

  2018cites this paper
• Hybrids and hybridization in the Cryptococcus neoformans and Cryptococcus gattii species complexes.

  2018cites this paper
• Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection

  2018cites this paper
• Innate immune evasion strategies against Cryptococcal meningitis caused by Cryptococcus neoformans

  2017cites this paper
• Treatment with pCramoll Alone and in Combination with Fluconazole Provides Therapeutic Benefits in C. gattii Infected Mice

  2017influential citation
• Cryptococcus–Epithelial Interactions

  2017cites this paper
• IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD from Salmonella Typhimurium

  2017cites this paper
• Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5

  2017cites this paper
• Adaptive Immunity to Cryptococcus neoformans Infections

  2017cites this paper
• Trichoderma asperelloides Spores Downregulate dectin1/2 and TLR2 Receptors of Mice Macrophages and Decrease Candida parapsilosis Phagocytosis Independent of the M1/M2 Polarization

  2017cites this paper
• The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System

  2017cites this paper
• Investigating the molecular mechanisms of vomocytosis

  2017cites this paper
• Warfare and defense: The host response to Cryptococcus infection

  2017cites this paper
• Fungal derived 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote C. neoformans growth during infection

  2017cites this paper
• Epidemiology and optimal management of cryptococcal meningo-encephalitis associated with AIDS in Cameroon

  2017cites this paper
• The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection

  2016cites this paper
• What makes Cryptococcus gattii a pathogen?

  2016cites this paper
• Host Autophagy in Antifungal Immunity

  2016cites this paper
• The role of cryptococcal 3-hydroxy fatty acids in mediating interspecies interactions

  2016cites this paper
• University of Birmingham Cryptococcus

  2016cites this paper
• Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages

  2016influential citation
• Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

  2016cites this paper
• Cryptococcus neoformans Thermotolerance to Avian Body Temperature Is Sufficient For Extracellular Growth But Not Intracellular Survival In Macrophages

  2016cites this paper
• Cryptococcus : from environmental saprophyte to global 1 pathogen 2

  2016cites this paper
• Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome

  2016cites this paper
• Erratum for Voelz et al., Cytokine Signaling Regulates the Outcome of Intracellular Macrophage Parasitism by Cryptococcus neoformans

  2016cites this paper
• Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265.

  2016cites this paper
• Cryptococcus: from environmental saprophyte to global pathogen

  2015cites this paper
• Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis

  2015cites this paper
• Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs

  2015cites this paper
• Development of Protective Inflammation and Cell-Mediated Immunity against Cryptococcus neoformans after Exposure to Hyphal Mutants

  2015cites this paper
• Dancing cheek to cheek: Cryptococcus neoformans and phagocytes

  2015cites this paper
• The Cnes2 Locus on Mouse Chromosome 17 Regulates Host Defense against Cryptococcal Infection through Pleiotropic Effects on Host Immunity

  2015cites this paper
• Cytokine Profiles at Admission Can Be Related to Outcome in AIDS Patients with Cryptococcal Meningitis

  2015cites this paper
• Immunity to Cryptococcus neoformans and C. gattii during cryptococcosis

  2015influential citation
• Fungal Pathogens: Survival and Replication within Macrophages.

  2015cites this paper
• Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

  2015cites this paper
• Heteroresistance to Itraconazole Alters the Morphology and Increases the Virulence of Cryptococcus gattii

  2015cites this paper
• The IL-33 receptor (ST2) regulates early IL-13 production in fungus-induced allergic airway inflammation

  2015cites this paper
• Sporadic Cryptococcal Meningitis - A Rare Presentation.

  2015cites this paper
• Host immunity to Cryptococcus neoformans.

  2015cites this paper
• Adaptive immunity to fungi.

  2015cites this paper
• Cryptococcus neoformans–Induced Macrophage Lysosome Damage Crucially Contributes to Fungal Virulence

  2015cites this paper
• Adaptive Immunity to Fungi

  2014cites this paper
• Visualizing non-lytic exocytosis of Cryptococcus neoformans from macrophages using digital light microscopy.

  2014cites this paper
• The intracellular life of Cryptococcus neoformans.

  2014cites this paper
• Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome.

  2014cites this paper