PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation

K. Heo,Hakjoo Lee,P. Nigro,Tamlyn N Thomas,N. Le,Eugene B. Chang,C. McClain,Cynthia A. Reinhart-King,M. King,B. Berk,K. Fujiwara,C. Woo,J. Abe

Published 2011 in Journal of Cell Biology

ABSTRACT

Disturbed flow-mediated PKCζ–PIASy association is critical for p53 SUMOylation and induces p53 nuclear export and endothelial cell apoptosis.

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