BIOPHYSICALLY DETAILED MODELLING OF THE FUNCTIONAL IMPACT OF GENE MUTATIONS ASSOCIATED WITH THE ?SHORT QT SYNDROME?

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• Publication year

  2013

• Venue

  Unknown venue

• Publication date

  2013-02-04

• Fields of study

  Medicine

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  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Cardiac Cellular Electrophysiology

  2020influential reference
• Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.

  2012cited by this paper
• A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents.

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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
• Models of HERG gating.

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• The short QT syndrome: proposed diagnostic criteria.

  2011influential reference
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  2011cited by this paper
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  2011cited by this paper
• Long-term follow-up of patients with short QT syndrome.

  2011cited by this paper
• A novel mutation in the KCNH2 gene associated with short QT syndrome.

  2011influential reference
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
• Stoichiometry of the KCNQ1 - KCNE1 ion channel complex

  2010cited by this paper
• M cells in the human heart.

  2010influential reference
• The cardiac IKs channel, complex indeed

  2010influential reference
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  2010cited by this paper
• Transmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle

  2010cited by this paper
• DOLFIN: Automated finite element computing

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010influential reference
• Drug‐induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives

  2010cited by this paper
• Multistability property in cardiac ionic models of mammalian and human ventricular cells.

  2010cited by this paper
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  2010cited by this paper
• Inwardly rectifying potassium channels: their structure, function, and physiological roles.

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
• The sinoatrial node - its complex structure and unique ion channel gene programme.

  2009influential reference
• Applied Mechanics of Solids

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2009influential reference
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  2008cited by this paper
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  2008cited by this paper
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  2008influential reference
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007influential reference
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