Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Current opinion in pharmacology (Print)

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.coph.2010.07.003PMID 20829110
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver X receptor modulators: a review of recently patented compounds (2007 – 2009)

  2010cited by this paper
• Liver X receptor in cholesterol metabolism.

  2010cited by this paper
• LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

  2009cited by this paper
• Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages.

  2009cited by this paper
• Abstract 1367: Tissue-specific Liver X Receptor Activation Promotes Macrophage Reverse Cholesterol Transport in vivo

  2009cited by this paper
• Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling*

  2009cited by this paper
• GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

  2009cited by this paper
• ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver.

  2008cited by this paper
• Protein kinase C alpha modulates liver X receptor alpha transactivation.

  2008cited by this paper
• Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.

  2008cited by this paper
• The Liver X Receptor (LXR) and Hepatic Lipogenesis

  2007cited by this paper
• Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.

  2007cited by this paper
• Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells.

  2007cited by this paper
• Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.

  2007cited by this paper
• Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE

  2007cited by this paper
• The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor.

  2007cited by this paper
• The mechanism mediating the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317 Published, JLR Papers in Press, August 24, 2006.

  2006cited by this paper
• Phosphorylation of the liver X receptors

  2006cited by this paper
• Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis

  2006cited by this paper
• Stearoyl-Coenzyme A Desaturase 1 Deficiency Protects against Hypertriglyceridemia and Increases Plasma High-Density Lipoprotein Cholesterol Induced by Liver X Receptor Activation

  2006influential reference
• Different roles of liver X receptor α and β in lipid metabolism: Effects of an α-selective and a dual agonist in mice deficient in each subtype

  2006cited by this paper
• Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

  2006influential reference
• Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.

  2006cited by this paper
• Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

  2005cited by this paper
• Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.

  2005cited by this paper
• Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1 Coactivation of SREBP

  2005cited by this paper
• Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

  2004cited by this paper
• Expression of the Insulin-responsive Glucose Transporter GLUT4 in Adipocytes Is Dependent on Liver X Receptor α*

  2003cited by this paper
• Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic Gluconeogenesis*

  2003cited by this paper
• Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

  2003cited by this paper
• Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

  2003cited by this paper
• Phospholipid Transfer Protein Is Regulated by Liver X Receptors in Vivo *

  2002cited by this paper
• Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue.

  2002cited by this paper
• Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors*

  2002cited by this paper
• Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles*

  2002cited by this paper
• Synthetic LXR ligand inhibits the development of atherosclerosis in mice

  2002cited by this paper
• ANGPTL3 Decreases Very Low Density Lipoprotein Triglyceride Clearance by Inhibition of Lipoprotein Lipase*

  2002cited by this paper
• Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c*

  2002cited by this paper
• Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice.

  2001cited by this paper
• Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

  2001cited by this paper
• Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRα and LXRβ*

  2001cited by this paper
• Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

  2000cited by this paper
• Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

  2000cited by this paper
• Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element.

  2000cited by this paper
• A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

  2000cited by this paper
• Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

  1998cited by this paper
• Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.

  1998cited by this paper
• Bile acid biosynthesis.

  1992influential reference

• DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice

  2024cites this paper
• The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and treatment options

  2022cites this paper
• Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy

  2021cites this paper
• Assessment of common and differentially expressed proteins between diabetes mellitus and fatty liver disease: a network analysis

  2021cites this paper
• Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation.

  2021cites this paper
• Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer

  2020cites this paper
• Discovery of new LXRβ agonists as glioblastoma inhibitors.

  2020cites this paper
• The roles of liver X receptor α in inflammation and inflammation‐associated diseases

  2020cites this paper
• Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables

  2019cites this paper
• Adrenergic receptor beta-3 rs4994 (T>C) and liver X receptor alpha rs12221497 (G>A) polymorphism in Pakistanis with metabolic syndrome

  2019cites this paper
• Loss of transglutaminase 2 sensitizes for diet-induced obesity-related inflammation and insulin resistance due to enhanced macrophage c-Src signaling

  2019cites this paper
• Endurance training and LXR activation increased LXRα and ABCA1 transcripts in Wistar male rats

  2018cites this paper
• Role of SREBPs in Liver Diseases: A Mini-review

  2018cites this paper
• Sonic hedgehog signaling instigates high-fat diet–induced insulin resistance by targeting PPARγ stability

  2018cites this paper
• Quantitative proteomics analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153.

  2017cites this paper
• Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases.

  2017influential citation
• LXRs: The Key Regulators of Intermediary Metabolism in Metabolic Syndrome

  2017cites this paper
• Nogo‐B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate–activated protein kinase alpha–dependent pathway

  2016cites this paper
• Fatty Acid Desaturation and Elongation in Mammals

  2016cites this paper
• Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma

  2016cites this paper
• Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway

  2015cites this paper
• Deregulation of fatty acid metabolism and cannabinoid receptors in liver of morbidly obese women with non-alcoholic fatty liver disease

  2015cites this paper
• Discovery and Synthesis of a Novel Series of Liver X Receptor Antagonists.

  2015cites this paper
• Association of liver X receptor α (LXRα) gene polymorphism and ischemic stroke.

  2015cites this paper
• Association between the LXRα polymorphism and stroke in a Chinese population.

  2015cites this paper
• Activation of Liver-X-Receptor &agr; But Not Liver-X-Receptor &bgr; Protects Against Myocardial Ischemia/Reperfusion Injury

  2014cites this paper
• Association of liver X receptor α (LXRα) gene polymorphism and coronary heart disease, serum lipids and glucose levels

  2014cites this paper
• Insulin-Sensitizing Effect of LXR Agonist T0901317 in High-Fat Fed Rats is Associated with Restored Muscle GLUT4 Expression and Insulin-Stimulated AS160 Phosphorylation

  2014cites this paper
• Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes

  2014cites this paper
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  2014cites this paper
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  2013cites this paper
• Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.

  2013cites this paper
• Lack of Liver X Receptors Leads to Cell Proliferation in a Model of Mouse Dorsal Prostate Epithelial Cell

  2013cites this paper
• Lack of association between LXRα and LXRβ gene polymorphisms and prevalence of metabolic syndrome: a case-control study of an Iranian population.

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• Moro orange juice prevents fatty liver in mice.

  2012cites this paper
• Recetores nucleares na terapêutica antidiabética

  2012influential citation
• Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines

  2012cites this paper
• Apolipoprotein E Genotype: The Innocent Bystander or Active Bridge Between Metabolic Syndrome and Cognitive Impairment?

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• Influence of chronic stress on the compositions of hepatic cholesterol and triglyceride in male Wistar rats fed a high fat diet

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• Cyanidin-3-O-β-glucoside upregulates hepatic cholesterol 7α-hydroxylase expression and reduces hypercholesterolemia in mice.

  2012cites this paper
• Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes

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• The Liver X Receptor Agonist T0901317 Protects Mice from High Fat Diet-Induced Obesity and Insulin Resistance

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• MiR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression.

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• Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men.

  2011cites this paper
• TRANSPORTERS

  2011cites this paper
• Guide to Receptors and Channels (GRAC), 5th edition

  2011cites this paper
• CATALYTIC RECEPTORS

  2011cites this paper
• ION CHANNELS

  2011cites this paper
• ENZYMES

  2011cites this paper
• Consultants

  2011cites this paper
• Structural and Functional Alteration of Full Length PPARα and LXRα by Fatty Acids and their Thioesters

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• Unraveling the intricacies of receptor activated cell signaling and transcriptional cascades enhance opportunities to develop new therapeutic targets for endocrine and metabolic diseases.

  2010cites this paper
• Novel targets in the liver to treat cardiometabolic diseases

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• Clinical and Experimental Gastroenterology Dovepress Molecular Pathways in Non-alcoholic Fatty Liver Disease

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