AIM To establish if the juice of Moro, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity. METHODS Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or Moro juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed. RESULTS Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. Moro juice administration limited body weight gain, enhanced insulin sensitivity, and decreased serum triglycerides and total cholesterol. Mice fed HFD showed liver steatosis associated with ballooning. Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase, a key enzyme of lipid oxidation. Consistently, Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase, and restored liver glycerol-3-phosphate acyltransferase 1 activity. CONCLUSION Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.
Moro orange juice prevents fatty liver in mice.
F. Salamone,G. Li Volti,L. Titta,L. Puzzo,I. Barbagallo,Francesco La Delia,S. Zelber-Sagi,M. Malaguarnera,P. Pelicci,M. Giorgio,F. Galvano
Published 2012 in World Journal of Gastroenterology
ABSTRACT
PUBLICATION RECORD
- Publication year
2012
- Venue
World Journal of Gastroenterology
- Publication date
2012-08-07
- Fields of study
Agricultural and Food Sciences, Medicine, Biology
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- acylcoa-oxidase
An enzyme involved in fatty acid oxidation whose liver expression was assessed.
Aliases: acyl-CoA oxidase, ACOX
- fatty acid synthase
A lipogenic enzyme whose liver expression was assessed in the study.
Aliases: FAS
- glycerol-3-phosphate acyltransferase 1
A liver enzyme related to glycerolipid synthesis whose activity was measured.
Aliases: GPAT1
- high-fat diet
A lipid-rich feeding regimen used to induce obesity and metabolic dysfunction in the mice.
Aliases: HFD
- liver steatosis
Excess lipid accumulation in the liver tissue assessed by morphology in the mouse model.
Aliases: fatty liver, hepatic steatosis
- liver x receptor-α
A nuclear receptor and transcription factor involved in lipid metabolism that was measured in liver tissue.
Aliases: LXR-α, LXR alpha
- moro juice
Juice prepared from Moro orange that was administered to mice in the feeding experiment.
Aliases: juice of Moro, Moro orange juice
- peroxisome proliferator-activated receptor-α
A nuclear receptor and lipid-metabolism transcription factor measured in liver tissue.
Aliases: PPAR-α, PPAR alpha
REFERENCES
Showing 1-33 of 33 references · Page 1 of 1
CITED BY
Showing 1-81 of 81 citing papers · Page 1 of 1