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A randomized trial on the effects of CitrusiM® (Citrus sinensis (L.) Osbeck dried extract) on body composition

Carolina Schettino Kegele,J. Oliveira,Taiana Magrani,A. S. Ferreira,R. S. Ferreira,Arman Sabbaghi,Anderson Ferreira,M. Brandão,N. Raposo,H. Polonini

Published 2019 in Clinical Nutrition Experimental

ABSTRACT

Summary Objective In this report, we investigated the effects of CitrusiM (Citrus sinensis (L.) Osbeck dried extract) on body composition, defined in terms of three outcomes: percentage of lean mass, percentage of fat mass, and waist circumference. Research Methods & Procedures A double-blind randomized experiment with overweight and obese volunteers was conducted in which the three variables were measured at baseline and three months afterwards. The treatment levels corresponded to three different daily doses of CitrusiM: 0 mg (control), 0.5 g, and 1 g. All patients met with a nutritionist, and were given a standardized diet with their assigned treatments. At the end of three months, the intermediate outcomes of diet compliance (in percent) and amount of exercise (either none, low level, or high level) were recorded. The covariates that were collected for each subject were age, height, and sex. We analyzed the effects of the treatments on the three outcomes under a Bayesian framework of the Rubin Causal Model, and accounted for possible relationships between both diet compliance and exercise level and the three outcomes of interest in the analyses. Study registered under Research Ethics Committee of the Faculdade de Ciencias Medicas e da Saude de Juiz de For a (plataformabrasil.gov.br): Identifier no. 2.767.611. Results There was a statistically significant evidence that the treatment may increase lean mass and reduce fat mass and waist circumference. Conclusion A 3-month treatment with CitrusiM (0.5g or 1g, daily) was able to increase lean mass, reduce fat mass, and reduce waist circumference in the participants.

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